Clinical trials: sponsored by Samsung Medical Center
Alzheimer's Disease, Dementia
Clinical Trial of Donepezil Between the Naive Group and the Switching Group
To compare the clinical efficacy of donepezil between the naive group and the switching group.
- Trial name
- NCT01023425
- Testing
- donepezil
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
Alzheimer's Disease, Dementia
Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia
To compare the clinical efficacy of donepezil between patients with Alzheimer's disease and Mixed Dementia.
- Trial name
- NCT01023867
- Testing
- donepezil
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Samsung Medical Center
Dementia
Characteristics of Treatment Responders to Galantamine
To investigate the characteristics of treatment responders to galantamine.
- Trial name
- NCT01029132
- Testing
- galantamine
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Depression
Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
The purpose of this study is to determine whether pharmacogenomic study of bioamine transporters and peripheral lymphatic biomarkers(phenotype) predict antidepressant responsiveness in advance before the appearance of the drug…
- Trial name
- NCT01352559
- Testing
- responders, non-responders
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depression
Pharmacogenetic Study of Mirtazapine Response in Depressed Patients
The purpose of this study is to determine whether pharmacogenetic study predict Mirtazapine responsiveness in advance before the appearance of the drug effect until 4-6 weeks after administration of Mirtazapine.
- Trial name
- NCT01039740
- Testing
- Mirtazapine
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Depression, Antidepressant Drug Adverse Reaction
Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness
The Purpose of this study is to predict antidepressant response in advance using pharmacogenomics and peripheral biological markers in depressed patients.
- Trial name
- PG (NCT00817011)
- Testing
- SSRI treated group, non-SSRI treated group
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depression, Adverse Reaction to Drug
Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients
The purpose of this study is to determine whether pharmacogenomic study predict antidepressant responsiveness in advance before the appearance of the drug effects until 4~6 weeks after drug administration.
- Trial name
- NCT00817375
- Testing
- SSRI treated group, non-SSRI treated group
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation(rTMS) in the Treatment of Depression
The objective of this study is to investigate the antidepressant efficacy of rTMS, and to assess cortical metabolism before and after rTMS sessions in patients with major depression.
- Trial name
- NCT01198561
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Depression, Continuous Antidepressant Abuse
Development of Escitalopram Genomic Device by Using Candidate Gene Approach and Genome-Wide Scanning
To reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning).
- Conditions
- Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug
- Trial name
- NCT00935246
- Testing
- Escitalopram
- Where
- South Korea
- Volunteers
- 202 people
- Sponsor
- Samsung Medical Center
Depression, Depressive Symptoms
Predict Antidepressant Responsiveness Using Pharmacogenomics
The purpose of this study is to determine whether genetic information associated with individual depressive symptoms.
- Trial name
- NCT01228357
- Testing
- SSRI treated group, non-SSRI treated group
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depression
Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
The purpose of this study is to determine whether alteration of signal transduction components after antidepressant targeting, predict antidepressant responsiveness in advance before the appearance of the drug effects until 4~6…
- Trial name
- NCT01352572
- Testing
- antidepressant response, antidepressant non-response
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depression, Continuous Antidepressant Abuse
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients
First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major…
- Conditions
- Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug
- Trial name
- NCT01237275
- Testing
- SSRI treated group
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Advanced or Recurrent Esophageal Squamous Cell Carcinoma
Phase II Trial of XP Versus XG in Advanced Esophageal Squamous Cell Carcinoma
Until today, the 5-FU/cisplatin combination is the reference regimen with 30-45% response rates, which is most commonly used to treat patients with metastatic, recurrent or locally advanced, unresectable squamous cell carcinoma…
- Trial name
- NCT01474642
- Testing
- Capecitabine/Cisplatin(XP), Capecitabine/Paditaxel(XG)
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Samsung Medical Center
Metastatic Carcinoma, Recurrent Esophageal Squamous Cell Carcinoma
Study of Docetaxel and Gemcitabine in Metastatic Esophageal Squamous Cell Cancer
Gemcitabine is a novel analog of the nucleoside deoxycytidine that acts via inhibition of DNA synthesis.Docetaxel is a semisynthetic taxane and promotes microtubule assembly and inhibits microtubule depolymerization.
- Trial name
- NCT01469598
- Testing
- Gemcitabine/Docetaxel
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Samsung Medical Center
Neuroendocrine Tumor
Study of Pazopanib Monotherapy in Patients With Unresectable, Metastatic Neuroendocrine Tumor
To determine the response rate of pazopanib when administered as monotherapy in patients with unresectable neuroendocrine tumor.
- Trial name
- NCT01099540
- Testing
- Pazopanib
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Samsung Medical Center
Metastatic Gastric Cancer
A Trial of RAD001/Capecitabine in Refractory Gastric Cancer
Capecitabine is an oral fluoropyrimidine that has been shown to be effective in the treatment of metastatic gastric and colorectal cancer patients.
- Trial name
- NCT01099527
- Testing
- Everolimus (RAD001), Capecitabine
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Samsung Medical Center
Metastatic Melanoma With KIT Aberration
Study of Nilotinib in Metastatic Melanoma With KIT Aberrations
Major response was observed to imatinib mesylate in KIT-mutated metastatic rectal melanoma (Hodi FS et al, J Clin Oncol 26:2046-2051, 2008).
- Trial name
- NCT01099514
- Testing
- Nilotinib
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Medical Center
Metastatic Cancer
Next pErsonalized Cancer tX With mulTi-omics and Preclinical Model
The next generation of personalized medical treatment according to the type of personal genetic information are evolving rapidly.
- Trial name
- NEXT-1 (NCT02141152)
- Where
- South Korea
- Volunteers
- 895 people
- Sponsor
- Samsung Medical Center
Irritable Bowel Syndrome
Colonoscopy-related Pain Predicts the Treatment Response of Amitriptyline in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a functional bowel disorder with recurrent abdominal pain and disordered defecation and is one of the most common gastrointestinal problems.
- Trial name
- NCT02638870
- Testing
- Amitriptyline
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Samsung Medical Center
Osteoarthritis, Knee
Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint
The purpose of this study is to compare the efficacy of platelet-rich plasma versus hyaluronic acid intra-articular injections for the treatment of osteoarthritis of knee joint.
- Trial name
- NCT02211521
- Testing
- PRP, Hyaluronic acid
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Samsung Medical Center