Clinical trials: sponsored by Samsung Medical Center
Breast Cancer
Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
Intravenous form of ibuprofen is recently approved by FDA and reports are rare on the co-administration with opioids. The investigators searched whether intravenous ibuprofen-hydromorphone combination is synergistic, additive, or…
- Trial name
- NCT02461056
- Testing
- Ibuprofen, Hydromorphone
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Samsung Medical Center
Kidney Transplantation
Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation
The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.
- Trial name
- NCT02459470
- Testing
- Fluid loading
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Samsung Medical Center
Healthy
Pharmacodynamic Drug Interaction Between Cilostazol and Statins
The purpose of this study is to evaluate pharmacodynamic drug interaction between cilostazol and statins (simvastatin as a CYP3A substrate and rosuvastatin as a non-CYP3A substrate) in healthy male subjects.
- Trial name
- SMCCPT-100 (NCT01870466)
- Testing
- Cilostazol, Simvastatin, Rosuvastatin
- Where
- South Korea
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Intermittent Exotropia
Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries
Background and study aims : The investigators conducted this study to compare the movement of extraocular muscle after two types of recession surgery with non-invasive tool called AS-OCT.
- Trial name
- AS-OCT (NCT02450162)
- Testing
- lateral rectus recession (bilateral)
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Healthy
Effect of Cilostazol on the Pharmacokinetics of Simvastatin
To evaluate the effect of cilostazol on the pharmacokinetics of simvastatin in healthy adult subjects.
- Trial name
- NCT01383395
- Testing
- simvastatin/cilostazol
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Trigger Finger
Effect of Steroid Injection Which is Added to Percutaneous Trigger Finger Release: a Double-blinded Randomized Controlled Trial.
Background Present treatment strategies for trigger finger when conservative management including steroid injection was failed include percutaneous or open A1 pulley release, but some people showed prolonged swelling and delay of…
- Trial name
- NCT01781130
- Testing
- Steroid injection
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Samsung Medical Center
Recruiting, Completed
The Effect of Ligasure® to Destroy Cornual Portion of Fallopian Tube
Single-center prospective randomized trial to evaluate the effect of thermal damage of Ligasure® to destroy cornual portion of fallopian tube tisse.
- Trial name
- NCT01894971
- Testing
- The Effect of Ligasure® to Destroy Cornual Portion of Fallopian Tube
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Leukemia, Chronic Myeloid
Multicenter, PhaseⅣ, Open Label Trial of Nilotinib in Adult Patients Diagnosed Philadelphia Chromosome Positive(Ph+) Chronic Myeloid Leukemia in CP/AP Intolerant to Dasatinib
Describe the purpose of the study: This study aims to evaluate the improvement of Dasatinib-related adverse events and to evaluate the treatment effect and safety by measuring the genetic response of nilotinib with nilotinib…
- Trial name
- NCT02389920
- Testing
- Nilotinib
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Intermittent Exotropia
Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT)
•Background and study aims : The investigators conducted this study to evaluate the movement of extraocular muscle after strabismus surgery with non-invasive tool called AS-OCT.
- Trial name
- NCT02383381
- Testing
- lateral rectus recession
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Osteoarthritis, Hip, Femur Head Necrosis
Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty
This prospective study compares an oral direct factor Xa inhibitor with LMWH for thromboprophylaxis in the patients undergoing THA.
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Femoral Neck Fractures
- Trial name
- NCT02379663
- Testing
- Rivaroxaban, Enoxaparin, Normal saline
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Concomitant Chemo-radiotherapy Followed by MIDLE Chemotherapy in Stage I/II Extranodal NK/T-cell Lymphoma
The purpose of this study is to evaluate the efficacy of concomitant chemoradiation followed by MIDLE chemotherapy for stage I/II extranodal NK/T cell lymphoma.
- Trial name
- NCT01238159
- Testing
- CCRT+MIDLE chemotherapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Diffuse Large B-cell Lymphoma
Prospective Cohort Study With Central Nervous System Evaluation in Diffuse Large B-cell Lymphoma
This study is to evaluate the incidence of central nervous system (CNS) relapse or metastasis in patients with diffuse large B-cell lymphoma.
- Trial name
- PROCESS (NCT01202448)
- Testing
- CSF analysis
- Where
- 2 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Samsung Medical Center
Peripheral T Cell Lymphoma Unspecified, Anaplastic Large Cell Lymphoma, ALK-negative
RAD001 Combined With CHOP in Newly Diagnosed Peripheral T-cell Lymphomas
The urgent need for new effective therapy for T-cell lymphoma patients and promising results observed so far in trials with RAD001(everolimus, mTOR inhibitor) strongly warrants the investigation of RAD001 combined with CHOP as a…
- Conditions
- Peripheral T Cell Lymphoma Unspecified, Anaplastic Large Cell Lymphoma, ALK-negative, Angioimmunoblastic T Cell Lymphoma, Cutaneous T Cell Lymphoma
- Trial name
- RADCHOP (NCT01198665)
- Testing
- RAD001 (Everolimus)
- Where
- 5 sites in South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Intubation, Intratracheal, Thoracic Surgical Procedures
Modified Angled Tube vs. Conventional Angled Tube in Double-lumen Endotracheal Tube Intubation
The investigators are trying to compare the individually modified-angled tube and the conventional-angled tube in ease of double lumen endotracheal tube insertion and the incidence of related postoperative complications.
- Trial name
- NCT02190032
- Testing
- Mallinckrodt endotracheal tube with a modified angle, Mallinckrodt endobronchial tube with a conventional angle
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Samsung Medical Center
Helicobacter Pylori Infection
Randomized Study on Efficacy of Gemifloxacin-based Regimen for Helicobacter Pylori Infection
New generations of fluoroquinolones, like levofloxacin and moxifloxacin, exhibit a broad-spectrum activity against Gram-positive and Gram-negative bacteria, and have been successfully introduced into the treatment of Helicobacter…
- Trial name
- NCT02368470
- Testing
- Gemifloxacin-based triple therapy, Standard triple therapy
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Samsung Medical Center
Pancreatic Mucinous-Cystic Neoplasm
Endoscopic Ultrasonography-guided Double Ethanol Lavage for Pancreatic Cysts: a Prospective Cohort Study
Due to widespread use of cross-sectional imaging modalities, pancreatic cysts are common in abdominal image. These lesions encompass a wide spectrum, ranging from benign to malignant.
- Trial name
- NCT02213419
- Testing
- Endoscopic ultrasonography-guided double ethanol lavage
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Biliary Tract Neoplasms
Fully Covered SEMS Versus Partially Covered SEMS With Anti-migration System for Malignant Distal Biliary Obstruction
The purpose of this study is to compare the duration of stent patency between partially covered and fully covered SEMS for palliation of malignant distal bile duct obstruction.
- Trial name
- NCT02255669
- Testing
- partially covered SEMS, fully covered SEMS
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Samsung Medical Center
Septic Shock
Discontinuation Order of Vasopressors in Septic Shock
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the…
- Trial name
- DOVSS (NCT01493102)
- Testing
- Vasopressin, Norepinephrine
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Immune Thrombocytopenia
An Observational Study to Evaluate the Efficacy of Biweekly Romiplostim in Adult Patients With ITP
The aim of this study is to evaluate the efficacy of romiplostim administered at every other week in ITP patients who attained stable platelet counts ≥ 50 x 109/L for 4 consecutive weeks after weekly doses of romiplostim.
- Trial name
- NCT02338414
- Testing
- Romiplostim
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Osteochondral Lesion of Talus
Safety and Efficacy of Allogenic Umbilical Cord Blood-derived Mesenchymal Stem Cell Product
The purpose of this study is to evaluate the safety and efficacy of adding allogenic umbilical cord blood-derived stem cell product(Cartistem®) on currently standard treatment of arthroscopic curettage and microfracture for…
- Trial name
- Cartistem (NCT02338375)
- Testing
- Cartistem
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samsung Medical Center