Clinical trials: sponsored by Samsung Medical Center
Epiretinal Membrane
Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane
Fovea is characterized by its vessel-free zone, called foveal avascular zone and it can be visualized by fluorescein angiography.
- Trial name
- NCT01985490
- Testing
- epiretinal membrane and internal limiting membrane removal
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation
Efficacy of Propafenone Versus Dronedarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation
the purpose of this study is to compare the ability of propafenone and dronedarone to maintain sinus rhythm after DC cardioversion
- Trial name
- NCT01991119
- Testing
- Propafenone, Dronedarone
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Samsung Medical Center
Alzheimer's Disease
Zydena on Cognitive Function of Alzheimer's Disease Patients
The purpose of this study is to determine whether Zydena (Udenafil) has positive effect on cognitive function in patients with Alzheimer's disease. This study is a randomized, double blind, placebo-controlled multicenter study.
- Trial name
- NCT01940952
- Testing
- Zydena (Udenafil) 50mg + Donepezil 5mg or 10mg, Zydena (Udenafil) 100mg + Donepezil 5mg or 10mg
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Samsung Medical Center
Perimenopause
Oral Contraceptive During Menopausal Transition
Muscle or joint pain is one of the most common symptoms during menopausal transition. As this could be severe enough to affect social and daily life and to reduce quality of life, attentions should be paid about this.
- Trial name
- NCT01414530
- Testing
- oral contraceptive, NSAID
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Refractory Cancer
Patients Who Refractory Cancer Conqueror for Bio New Drug Development Translational Research Establishment
■ Unmet medical needs for Refractory cancer Conquest Many advanced cancers are still detected Despite remarkable technological advances for the early diagnosis of cancer in the field last 20 years.
- Trial name
- NCT01932047
- Where
- South Korea
- Volunteers
- 1,523 people
- Sponsor
- Samsung Medical Center
Histologically Proven Extranodal NKTcell Lymphoma
A Pilot Study of Romidepsin in Relapsed or Refractory Extranodal NK/T-cell Lymphoma
Extranodal NK/T-cell lymphoma is a rare disease entity with aggressive clinical course and poor prognosis. Currently, there is no treatment option for relapsed or refractory extranodal NK/T-cell lymphoma.
- Trial name
- Ro-ENKTL (NCT01913119)
- Testing
- Romidepsin
- Where
- 4 sites in South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Other Functional Disturbances Following Cardiac Surgery, Postoperative Hemorrhage
A Gray Zone Approach of Rotational Thromboelastometry for Predicting Postoperative Bleeding in Cardiac Surgical Patients
Rotational thromboelastometry (ROTEM) is reliable point of care management of coagulation disorder undergoing surgery. Recently, there are some reports about prediction of perioperative bleeding using ROTEM.
- Conditions
- Other Functional Disturbances Following Cardiac Surgery, Postoperative Hemorrhage, Coagulation Defect; Bleeding
- Trial name
- NCT01889732
- Testing
- ROTEM
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
Trial of XELIRI/FOLFIRI + Simvastatin Followed by Simvastatin Maintenance in Metastatic Colorectal Cancer
The purpose of this study is to compare 2nd line XELIRI/FOLFIRI + simvastatin vs XELIRI/FOLFIRI + placebo.
- Trial name
- NCT01238094
- Testing
- Simvastatin
- Where
- South Korea
- Volunteers
- 258 people
- Sponsor
- Samsung Medical Center
Metastatic Colorectal Cancer
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)
Based on the results from preclinical study, the investigators suggest that the addition of simvastatin at a dose of cardiovascular use (40 ~ 80 mg qd daily) may overcome cetuximab resistance in KRAS mutant colorectal cancer via…
- Trial name
- NCT01281761
- Testing
- cetuximab/irinotecan/simvastatin
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer, Unresectable Liver Metastasis
Neoadjuvant FOLFOX6 + Cetuximab in Patients With Colorectal Cancer and Unresectable Liver Metastasis
An innovative therapeutic strategy to increase the complete resection rate is of utmost importance in order to enhance survival in colorectal cancer patients with unresectable liver-only metastasis.
- Trial name
- NCT00743678
- Testing
- FOLFOX6/cetuximab
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
Study of S-1 and Oxaliplatin (SOX) Versus Capecitabine and Oxaliplatin (COX) in Patients With Advanced Colorectal Cancer
Primary objective : To compare the combination of S-1 and oxaliplatin(SOX) to the combination of capecitabine and oxaliplatin(COX) therapy for advanced or metastatic colorectal carcinoma. Secondary objectives : 1.
- Trial name
- NCT00677443
- Testing
- S-1 & Oxaliplatin, Capecitabine & Oxaliplatin
- Where
- 11 sites in South Korea
- Volunteers
- 344 people
- Sponsor
- Samsung Medical Center
Phase I: To Determine the Maximum Tolerated Dose (MTD), Phase II: To Assess the Pathologic CR Rate and Feasibility Following Neoadjuvant Chemoradiation Therapy With S1/Oxaliplatin
Phase I/II Study of Neoadjuvant Chemoradiotherapy With S-1/ Oxaliplatin in Patients With Gastric Cancer: Randomized Phase II Study of S-1/RT vs. S-1/Oxaliplatin/RT
To evaluate the efficacy of preoperative S-1/oxaliplatin/RT in locally advanced gastric cancer
- Trial name
- NCT01106066
- Testing
- Oxaliplatin, S-1, radiotherapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
PD
Phase IV Study to Evaluate the Efficacy and Safety of Mircera in PD
The primary objective of study is to evaluate the no of patients which maintain the Hb level between 9.0 ~ 12.0 g/dl during the evaluation period
- Trial name
- NCT01807481
- Testing
- Mircera
- Where
- 2 sites in South Korea
- Volunteers
- 101 people
- Sponsor
- Samsung Medical Center
Benign Prostatic Hyperplasia
The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia
Non-steroidal Anti-inflammation Drugs can effectively reduce the lower urinary tract symptoms from benign prostatic hyperplasia
- Trial name
- NCT00687388
- Testing
- selective alpha 1-blockers, celecoxib, alpha-blocker and NSAID
- Where
- 3 sites in South Korea
- Sponsor
- Samsung Medical Center
Voiding Dysfunction
Efficacy and Safety of Alfuzosin for the Treatment of Voiding Dysfunction in Female
The purpose of this study is to explore the efficacy of Alfuzosin (10 mg, qd) in reducing the score of International Prostate Symptom Score (IPSS) from baseline to 8 weeks of treatment in female patients with voiding dysfunction.
- Trial name
- NCT00679315
- Testing
- alfuzosin hydrochloride XL 10mg
- Where
- 9 sites in South Korea
- Volunteers
- 190 people
- Sponsor
- Samsung Medical Center
Sleep Apnea
Clinical Predictors of Apnea-hypopnea During Propofol Sedation
To relate two different predictive values of sleep apnea: the STOP score (snoring while sleeping, daytime tiredness, observed breathing stoppages, and high blood pressure) and the estimated respiratory disturbance index (eRDI)…
- Trial name
- sleeposa (NCT01871259)
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Small Cell Lung Cancer
Combination Anticancer Therapy of Paclitaxel and Everolimus for Relapsed or Refractory Small Cell Lung Cancer
The objective of this phase I study is to determine the maximum tolerated dose (MTD) of combination therapy of paclitaxel and everolimus in small cell lung cancer patient with previous treatment history.
- Trial name
- NCT01079481
- Testing
- taxol plus everolimus
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
Small Cell Lung Cancer
Early Versus Late Concurrent Chemoradiation for Limited Stage Small-cell Lung Cancer
The purpose of the study is to evaluate the efficacy and toxicity of different timing of concurrent chemoradiation in the treatment of limited disease status Small-cell lung cancer.
- Trial name
- NCT01125995
- Testing
- early CCRT, late CCRT
- Where
- 2 sites in South Korea
- Volunteers
- 222 people
- Sponsor
- Samsung Medical Center
Lung Neoplasms, Erlotinib
Efficacy of Erlotinib in Neoadjuvant Setting in Patients With Stage IIIA, N2-positive Non-Small Cell Lung Cancer
This study propose neoadjuvant chemotherapeutic role by erlotinib.
- Conditions
- Lung Neoplasms, Erlotinib, Neoadjuvant Therapy
- Trial name
- NCT01130753
- Testing
- Erlotinib
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Overactive Bladder
Assessment of Patient-reported Goal Attainment in the Treatment of Female Overactive Bladder
For many years, antimuscarinics have been first-line pharmacological treatment for OAB. A recent meta-analysis of randomised, controlled trials on antimuscarinic treatment of OAB concluded that the drugs provide significant…
- Trial name
- NCT00836381
- Testing
- Tolterodine extended-release (ER) 4mg
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Samsung Medical Center