Clinical trials: sponsored by Samsung Medical Center
Uterine Myoma, Uterine Adenomyosis
Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy
Multi-center prospective randomized trial of single port laparoscopic surgery (SILS) versus conventional 3-4 ports laparoscopic hysterectomy.
- Trial name
- NCT01483417
- Testing
- Single incision Laparoscopic hysterectomy, Conventional laparoscopic hysterectomy
- Where
- 8 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma
Trial of S-1 in Combination With Sorafenib for Patients With Advanced Hepatocellular Carcinoma
In preclinical studies, 5-fluorouracil, one of the active metabolites of S-1, showed synergistic effect to sorafenib in human colon carcinoma cell lines.
- Trial name
- NCT01131689
- Testing
- sorafenib, TS-1
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer, Metastasis
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC
This trial is designed to assess the tolerability and efficacy of simvastatin plus FOLFIRI (irinotecan, 5-FU, leucovorin) in metastatic colorectal cancer patients.
- Trial name
- NCT00313859
- Testing
- simvastatin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Pseudoexfoliation Syndrome
LOXL1 Polymorphism in Pseudoexfoliation Syndrome
To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.
- Trial name
- NCT01515735
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Gastrointestinal Stromal Tumors
Sorafenib for Imatinib/Sunitinib-failed GIST
With discovery of KIT (CD117) mutations and the advent of KIT tyrosine kinase inhibitor imatinib, there has been substantial improvement in overall survival in patients with advanced and/or metastatic gastrointestinal tumors…
- Trial name
- NCT01091207
- Testing
- Sorafenib
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Samsung Medical Center
Advanced Gastric Cancer
Second-line Therapy Versus Supportive Care for Pretreated Advanced Gastric Cancer
Because well-designed, randomized, controlled clinical trials are lacking in patients with advanced gastric cancer (AGC), and because randomly allocating patients to treatments that do not accord with their preferences may…
- Trial name
- NCT00821990
- Testing
- Chemotherapy, Best supportive care
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Gastric Cancer, Metastases
Phase III Trial of DP Followed by FOLFIRI or the Reverse Sequence in Unresectable Gastric Cancer
To assess the optimal sequence of the palliative chemotherapy regimen (DP --> FOLFIRI vs FOLFIRI --> DP) in metastatic gastric cancer patients.
- Trial name
- NCT00313872
- Testing
- DP, FOLFIRI
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Latent Tuberculosis Infection
Diagnosis of Tuberculosis Infection in Health Care Workers Using Ex-vivo Interferon-gamma Assay
The present study was to evaluate the usefulness of a whole-blood interferon-r release assays (IGRAs) as diagnostic tool of the latent tuberculosis infection for healthcare workers.
- Trial name
- NCT01007396
- Testing
- 1-step tuberculin skin test (TST) and blood sampling
- Where
- South Korea
- Volunteers
- 322 people
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer
Whole-Body Magnetic Resonance Imaging/Positron Emission Tomography (MRI/PET) in the Staging of Non-Small-Cell Lung Cancer (NSCLC)
The accurate staging is an essential part for the treatment and prognosis of non-small-cell lung cancer (NSCLC). Whole body MR imaging proved to be effective in staging of NSCLC as much as PET/CT.
- Trial name
- NCT01065415
- Where
- South Korea
- Volunteers
- 272 people
- Sponsor
- Samsung Medical Center
Thyroid Carcinoma, Thyroidectomy
Efficacy of Fibrin Sealant to Reduce the Amount of Post-thyroidectomy Drain
Fibrin sealant has been studied to reduce post-thyroidectomy drain and hospital stay as well. However, no strong evidence from well-designed clinical trials is available.
- Trial name
- NCT01126060
- Testing
- Usage of Fibrin sealant, Thyroidectomy
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Gastrointestinal Cancer
Biomarker Analysis of Gastrointestinal Cancer
BIOMARKER ANALYSES 1. FNA Sample: From each enrolled patient who meets the inclusion criteria, FNA sample will only be taken . FNA will be carried out only in patients with feasible biopsy or FNA site.
- Trial name
- NCT01484444
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Lung Adenocarcinoma
Study of Early-stage Lung Adenocarcinoma for Early Detection and Effective Treatment Strategy
to determine the values of imaging and genetic biomarkers for prediction of tumor aggressiveness and prognosis in patient with early stage lung adenocarcinoma to Identify unique copy number alteration in patient with early stage…
- Trial name
- NCT01482585
- Testing
- CT, PET, copy number alteration
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Prader-Willi Syndrome, Obesity
Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Willi Syndrome
Context: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.
- Trial name
- NCT01479322
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Epiretinal Membrane
Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal
The purpose of this study is to evaluate the changes in visual acuity, metamorphopsia, and thickness of retinal layers after epiretinal membrane removal and to investigate factors associated with visual function.
- Trial name
- NCT01474655
- Testing
- Pars plana vitrectomy and removal of epiretinal membrane
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Macular Holes
Elongation of Foveal Tissue After Macular Hole Surgery
In our experience, elongation of foveal tissue after macular hole surgery which was undetectable by conventional time-domain optical coherence tomography was often observed on spectral-domain optical coherence tomography images.
- Trial name
- NCT01471912
- Testing
- pars plana vitrectomy and fluid gas exchange
- Where
- South Korea
- Volunteers
- 31 people
- Sponsor
- Samsung Medical Center
Curatively-resected, Node-positive Esophageal Squamous Cell Carcinoma
Study of LV5FU2 Versus FOLFOX for Curatively-resected, Node-positive Esophageal Squamous Cell Carcinoma
Oxaliplatin is a platinum analogue that has significant antitumor activity with better tolerability than cisplatin. The objective of the study is to evaluate the safety and activity of leucovorin and 5-fluorouracil and leucovorin…
- Trial name
- NCT01467921
- Testing
- oxaliplatin
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Samsung Medical Center
Gastric Cancer, Surgery
Phase III Randomized Trial of Adjuvant XP Chemotherapy and XP/RT for Resected Gastric Adenocarcinoma
The objective of the trial is to compare disease-free survival between adjuvant capecitabine/cisplatin alone vs capecitabine/cisplatin with radiotherapy (chemoradiation) in curatively resected gastric cancer patients.
- Trial name
- NCT00323830
- Testing
- Capecitabine, cisplatin, Radiotherapy (+/-)
- Where
- South Korea
- Volunteers
- 458 people
- Sponsor
- Samsung Medical Center
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Benign Prostatic Hyperplasia
Clinical Effect and Safety of Tamsulosin 0.4mg in Patients With LUTS/BPH Refractory to Tamsulosin 0.2mg
The purpose of this study is to explore the efficacy and safety of tamsulosin 0.4mg (Harnal® D. 0.2mg, 2T) in patients with LUTS/BPH refractory to tamsulosin 0.2mg (Harnal® D 0.2mg, 1T).
- Trial name
- NCT00954889
- Testing
- tamsulosin
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Samsung Medical Center
Retinal Break, Retinal Detachment
Partial Posterior Hyaloidectomy in Macular Surgery
To evaluate the effect of partial posterior hyaloidectomy on preventing iatrogenic retinal breaks related to induction of a posterior vitreous detachment
- Trial name
- NCT01454466
- Testing
- Partial posterior hyaloidectomy (a modified procedure of vitrectomy)
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center