Clinical trials: sponsored by Samsung Medical Center
Cardiogenic Shock, Acute Kidney Injury
Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator
This study was designed to compare the safety and efficacy of early continuous renal replacement therapy with standard continuous renal replacement therapy in the presence of acute kidney injury (stage 2 or greater acute kidney…
- Trial name
- REDUCE-ECMO (NCT06696235)
- Testing
- Early initiation of continuous renal replacement therapy, Standard initiation of continuous renal replacement therapy
- Where
- 2 sites in South Korea
- Volunteers
- 408 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus Type 2, Continuous Glucose Measurement
Effectiveness of Individualized Automatic Coaching Message for Glycemic Management and Depressive Symptom
This is a 12-week, single-center, randomized, prospective, confirmatory study of effectiveness of the individualized automatic coaching messages for glycemic management based on continuous glucose monitoring and depressive…
- Conditions
- Diabetes Mellitus Type 2, Continuous Glucose Measurement, Depressive Symptom
- Trial name
- NCT06769906
- Testing
- Individualized automatic coaching message for glycemic management and depressive symptom
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Early Breast Cancer
This Clinical Trial is a Retrospective, Multicenter Cohort Study Evaluating the Real-world Characteristics and Risk of Disease Recurrence in Hormone Receptor-positive, HER2-negative Early Breast Cancer.
Primary objective: To describe event-free survival (EFS) in patients with stage I-III HR+/HER2- early breast cancer (EBC) who received curative surgery followed by systemic therapy.
- Trial name
- PRIORITY (NCT07309887)
- Where
- South Korea
- Volunteers
- 100,000 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction
Long-term Beta-blocker Therapy After Acute Myocardial Infarction
The aim of the study is to determine whether discontinuation of β-blocker after at least 1 year of β-blocker therapy is noninferior to continuation of β-blocker in patients without heart failure (HF) or left ventricular systolic…
- Trial name
- SMART-DECISION (NCT04769362)
- Testing
- Discontinuation of β-blocker
- Where
- South Korea
- Volunteers
- 2,540 people
- Sponsor
- Samsung Medical Center
Charcot-Marie-Tooth Disease, Type 1
Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E
Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral nerve disease that causes causes muscle atrophy, muscle weakness, sensory loss, balance disorder, gait disorder, blindness, hearing disorder, breathing disorder, vocal…
- Trial name
- NCT06218134
- Testing
- human Wharton's jelly-derived mesenchymal stem cells
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Samsung Medical Center
Ischemic Heart Disease, Coronary Artery Disease
Smart Angioplasty Research Team-Coronary CT Angiography Versus Standard Care as Follow-up Strategies in High-Risk Patients After PCI (SMART-CARE)
The aim of the SMART-CARE trial is to compare clinical outcomes between coronary CT angiography (CCTA) versus standard care as follow-up strategies in high-risk patients after percutaneous coronary intervention (PCI).
- Trial name
- SMART-CARE (NCT07009418)
- Testing
- Coronary CT Angiography (CCTA)
- Where
- 22 sites in South Korea
- Volunteers
- 3,500 people
- Sponsor
- Samsung Medical Center
Solid Tumor, Adult
Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion
The NRG1 gene is located on chromosome 8 (8p12 region) and encode NRG1. NRG1 gene is translated to generate six different proteins (I-VI) and at least 31 isoforms.
- Trial name
- NCT06383884
- Testing
- Patritumab Deruxtecan
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Locally Advanced Pancreatic Ductal Adenocarcinoma, Borderline Resectable Pancreatic Ductal Adenocarcinoma
PULSAR in Systemic Therapy for Pancreatic Cancer
Pancreatic cancer remains one of the malignancies with the lowest survival rates, largely due to late-stage diagnosis and the difficulty of achieving curative resection.
- Conditions
- Locally Advanced Pancreatic Ductal Adenocarcinoma, Borderline Resectable Pancreatic Ductal Adenocarcinoma, Oligometastatic Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT07269626
- Testing
- Personalized Ultrafractionated Adaptive Radiotherapy
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Samsung Medical Center
Cardiogenic Shock, Frailty
Prognostic Impact of Frailty in Cardiogenic Shock
The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are: Can frailty successfully predict outcomes in cardiogenic shock? Whether…
- Conditions
- Cardiogenic Shock, Frailty, Age
- Trial name
- NCT07260084
- Volunteers
- 207,419 people
- Sponsor
- Samsung Medical Center
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Smart Angioplasty Research Team-Optimal Strategy for Side Branch Stenting in Coronary Bifurcation Lesion With Drug-Coated Balloon
A prospective, multi-center, open-label, randomized controlled, superiority trial. The aim of the study is to compare clinical outcomes between upfront 2-stenting strategy versus upfront drug-coated balloon (DCB)-based hybrid…
- Trial name
- SMART-DCB (NCT07019350)
- Testing
- Upfront DCB-based hybrid strategy, Upfront 2-stenting strategy
- Where
- 3 sites in South Korea
- Volunteers
- 520 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Invasive Versus Non-invasive Approach in Symptomatic Patient With Non-High Risk Coronary Artery Stenosis
A pragmatic, prospective, multi-center, open label, randomized controlled, superiority trial. The study will compare clinical outcomes between invasive versus non-invasive approach as next diagnostic step in symptomatic patients…
- Trial name
- SMART-STEP (NCT05799092)
- Testing
- Invasive coronary angiography, Non-invasive functional test
- Where
- 22 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Healthy
Remimazolam Versus Midaszolam for Sedation in Diagnostic Upper Gastrointestinal Endoscopy
The goal of this clinical trial is to compare the efficacy of remimazolam with midazolam in patients undergoing gastrointestinal endoscopy.
- Trial name
- NCT05836545
- Testing
- Remimazolam, Midazolam
- Where
- South Korea
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Upper Tract Urothelial Carcinoma
Cisplatin-Based Chemotherapy Followed by Maintenance Avelumab in UTUC
A Prospective Phase II Study of Adjuvant Cisplatin-Based Chemotherapy followed by Maintenance Avelumab in Upper Tract Urothelial Carcinoma
- Trial name
- NCT07225374
- Testing
- Avelumab 10 mg/kg, Screening, Best Supportive Care (BSC)
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Head and Neck Advanced Research for Multi-Omics and Optimized Immunotherapy
Head and neck squamous cell carcinoma is a heterogeneous cancer with varying prognoses depending on anatomical location and characteristics, and advanced cancers have a poor prognosis.
- Trial name
- HARMONI (NCT07211139)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Oesophageal Squamous Cell Carcinoma
A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea
This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery
- Trial name
- NCT07201571
- Volunteers
- 3,131 people
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Head and Neck Cancer Omics/Integrated Precision Medicine (HOPE)
Study Background and Rationale Head and neck cancer (HNC) is the sixth leading cause of cancer-related death, with over 650,000 new cases diagnosed worldwide each year.
- Trial name
- HOPE (NCT07190573)
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Samsung Medical Center
Histologically Confirmed Metastatic or Locally Advanced Breast Cancer With no Radical Topical Treatment Available, If There is Liver Metastasis, Which the Researcher Believes Will be Difficult to Evaluate the Response Accurately With Bone Metastasis or CT
FDG PET-CT in Advanced Breast Cancer
This study is a prospective cohort study comparing metabolic response evaluation by F-18 FDG PET-CT versus conventional imaging for outcome stratification in patients with advanced breast cancer receiving first-line systemic…
- Trial name
- PET-000 (NCT07173868)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Early Gastric Cancer, Gastric Adenoma
Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients
Because advanced gastric cancer shows poor prognosis, it is important to detect early gastric cancer or precancerous gastric adenoma patients who have a cure rate of 95% or more.
- Trial name
- NCT04665687
- Where
- South Korea
- Volunteers
- 1,730 people
- Sponsor
- Samsung Medical Center
Breast Cancer Related Lymphedema
Factors Associated With Health-related Quality of Life in Patients With Breast Cancer-Related Lymphedema Undergoing Prospective Surveillance
Breast cancer-related lymphedema (BCRL) is a chronic condition that affects more than 1 in 5 breast cancer survivors. It causes swelling, pain, and reduced arm function, which can significantly impact quality of life.
- Trial name
- NCT07165275
- Where
- South Korea
- Volunteers
- 203 people
- Sponsor
- Samsung Medical Center