Clinical trials: sponsored by Samsung Medical Center
Coronary Artery Disease, Atherosclerosis
Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease
The aim of the study is to compare clinical outcomes between intravascular imaging-guided versus angiography-guided percutaneous coronary intervention (PCI) in complex lesions.
- Trial name
- RENOVATE (NCT03381872)
- Testing
- Percutaneous coronary intervention for complex lesion, Drug-eluting stent, Intravascular imaging (IVUS or OCT)
- Where
- South Korea
- Volunteers
- 1,639 people
- Sponsor
- Samsung Medical Center
Helicobacter Infection
Clinical Trial to Evaluate the Efficacy of Probit-Based Triple Therapy for Helicobacter Pylori Eradication
This is a single-center, open-label, non-randomized, single-arm clinical study. Eligible participants who provide written informed consent will undergo screening based on inclusion/exclusion criteria.
- Trial name
- NCT07115173
- Testing
- This study aims to evaluate the efficacy and safety of a 14-day triple therapy regimen consisting of Zastaprazan 20 mg, clarithromycin, and amoxicillin for the eradication of Helicobacter pylori.
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
Stereotactic Body Radiation Therapy (SBRT), Oligometastasis
SMC Radiation Oncology SABR Cohort for Oligometastasis
The goal of this observational study is to evaluate the efficacy and safety of stereotactic body radiotherapy (SABR) in patients with oligometastatic or oligoprogressive cancer. The main questions it aims to answer are: 1.
- Conditions
- Stereotactic Body Radiation Therapy (SBRT), Oligometastasis, Oligoprogression, ctDNA
- Trial name
- SABR-OMOP (NCT07121335)
- Testing
- Stereotactic body radiotherapy (SBRT)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Acute Respiratory Failure
Asymmetric High-flow Nasal Cannula (HFNC) vs Standard HFNC for Post Extubation High-risk Group
Background The exacerbation of respiratory failure that occurs after endotracheal intubation often occurs in patients who have received mechanical ventilation therapy, and when it occurs, it emerges as an important issue to…
- Trial name
- NCT06301035
- Testing
- Asymmetric High flow nasal cannula, Standard(symmetric) High flow nasal cannula
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Gallbladder Cancer
Artificial Intelligence-based Tumor Microenvironment Analysis for Prognosis Prediction in Gallbladder Cancer
This retrospective study aims to investigate the prognostic significance of artificial intelligence (AI)-powered analysis of tumor-infiltrating lymphocytes (TILs) and the tumor microenvironment (TME) in patients with resected…
- Trial name
- NCT07092397
- Where
- South Korea
- Volunteers
- 266 people
- Sponsor
- Samsung Medical Center
Interstitial Cystitis
Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients
efficacy of endoscopic ablation of Hunner lesions in patients with IC/BPS and the characteristics of HLs based on a long-term follow-up
- Trial name
- NCT03468530
- Testing
- Transurethral ablation
- Where
- South Korea
- Volunteers
- 442 people
- Sponsor
- Samsung Medical Center
General Anesthesia Using Endotracheal Intubation
Algorithm Predicting Intraoperative Changes in Cardiac Output Using Capnography
Conventional monitoring of cardiac output requires an invasive procedure and an additional device, which can lead to increased risk and cost.
- Trial name
- NCT07061548
- Testing
- No Intervention: Observational Cohort
- Where
- South Korea
- Volunteers
- 2,005 people
- Sponsor
- Samsung Medical Center
Diabetes (DM), Physical Activity
Effect of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity
Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using…
- Trial name
- PA-NormalWtDM (NCT07071545)
- Testing
- Regular physical activity, No regular physical activity
- Volunteers
- 249,247 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Impact of Potassium Competitive Acid Blockers After Percutaneous Coronary Intervention for Efficacy and Safety Outcome: Target Trial Emulation Study.
Despite the fact that potassium competitive acid blocker (P-CAB) has been developed for the treatment of gastric ulcer or gastroesophageal reflux disease, the efficacy and safety of P-CAB for the use of gastrointestinal (GI)…
- Trial name
- PCAB-PCI (NCT07068490)
- Testing
- Routine use of P-CAB on DAPT, Guideline Directed Medical Therapy
- Where
- South Korea
- Volunteers
- 100,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic Plaque
The aim of this prospective, open-label, randomized, single center study is to compare the effect of usual dose rosuvastatin plus ezetimibe and high-dose rosuvastatin on modifying atherosclerotic plaque.
- Trial name
- Rosuzet-IVUS (NCT03169985)
- Testing
- Rosuvastatin 10 mg plus ezetimibe 10 mg orally once a day, Rosuvastatin 20 mg orally once a day
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Samsung Medical Center
Esophagectomy, Esophageal Cancer
Non-gastric Conduit Reconstruction After Esophagectomy
This study is to collect and analyze the clinical information of patients who underwent reconstruction using conduits other than the stomach, such as the colon and small intestine, after esophagectomy.
- Trial name
- NCT07064655
- Volunteers
- 25 people
- Sponsor
- Samsung Medical Center
Disabilities, Type 2 Diabetes
The Impact of Medication Adherence in Patients With Type 2 Diabetes and Disabilities
Individuals with disabilities and type 2 diabetes tend to have worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators evaluated the role of medication adherence.
- Trial name
- NCT07052708
- Testing
- No adherence group, Adherence group
- Volunteers
- 365,295 people
- Sponsor
- Samsung Medical Center
Breast Cancer, Metastatic Breast Cancer
Prospective Observational Study on Outcome of High-precision Hypo-fractionated Radiotherapy in Metastatic Breast Cancer (PRECISE-M)
This study is a prospective observational study on outcomes of high precision hypo-fractionated radiotherapy in breast cancer with distant metastasis.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Radiation Therapy Complication
- Trial name
- NCT05907681
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Breast Cancer Stage III
Radiotherapy Dose Adaptation Based on Tumor Biology in Patients With cN2b-N3 Breast Cancer
The purpose of the study is to evaluate treatment outcomes of breast cancer with internal mammary or supraclavicular lymph node metastasis according to total radiation dose of postoperative radiation therapy differentiated by…
- Trial name
- RADAPT-N3 (NCT05896865)
- Testing
- Whole breast / chest wall & regional lymph node irradiation, Internal mammary or supraclavicular lymph node boost
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Breast Cancer
Oncologic Outcomes and Toxicities of Salvage Treatment in Patients With Locoregionally Recurrent Breast Cancer
The purpose of this study is to evaluate clinical outcomes and adverse events of salvage treatment for locoregional recurrence of breast cancer.
- Trial name
- SALT-LRR (NCT05933733)
- Testing
- Salvage treatment (surgery and/or radiation therapy)
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Samsung Medical Center
Melanoma
Evaluate the Safety and Efficacy of Autologous Tumor-infiltrating Lymphocyte in Patients With Refractory Melanoma Who Failed to Immune Checkpoint Inhibitors
For cancer patients who have failed conventional chemotherapy or are inoperable, targeted therapies-which block specific proteins involved in tumor growth-and immunotherapies-which activate T cells around the tumor to induce…
- Trial name
- NCT07028008
- Testing
- tumor-infiltrating lymphocyte (TIL)
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Acute Myocardial Infarction, Heart Failure
Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and…
- Trial name
- PRESTIGE-AMI (NCT04899479)
- Testing
- SGLT2 inhibitor, Control
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Arthroplasty, Replacement, Shoulder, Reverse Total Shoulder Arthroplasty
At Home, Digital Rehabilitation for Patients After Reverse Total Shoulder Arthroplasty
1. Why This Study Matters Over the past five years, more people in Korea have been having shoulder surgery. With our country moving into a super-aged society by 2025, these surgeries are expected to increase even more.
- Trial name
- DHI_RTSA (NCT06891378)
- Testing
- Intrevention group (mHealth group), control group (usual care)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety of Conventional Immunosuppressant Therapies in Elderly Patients With Neuromyelitis Optica Spectrum Disorder
Newly diagnosed NMOSD patients
- Trial name
- NCT07032337
- Volunteers
- 2,985 people
- Sponsor
- Samsung Medical Center
Esophageal Cancer
Developing an Ecological and Tailored Nutritional Intervention to Improve Quality of Life in Esophageal Cancer Survivors
This study aims to apply and assess the clinical feasibility of a health behavior theory-based ecological nutrition intervention program, providing nutrition care tailored to the unmet needs of esophageal cancer survivors after…
- Trial name
- NCT07024849
- Testing
- Ecological nutritional intervention
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center