Clinical trials: completed, sponsored by Samsung Medical Center
Communication
Effect of an AI Agent on Caregiver Communication Experience in the Pediatric Emergency Department
This single-center, single-blind, randomized controlled trial evaluates whether the use of a conversational large language model (LLM)-based AI agent, used by caregivers during the waiting period before physician consultation in…
- Trial name
- PED-AI (NCT07867782)
- Testing
- AI Agent (conversational LLM pre-consultation history-taking tool)
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Diabete Type 2, E Cigarette Use
Switching to E-Cigarettes After Type 2 Diabetes Diagnosis and Health Outcomes
Individuals with T2DM who smoke have higher risks of cardiovascular disease and other complications. Many people consider e-cigarette as a "harm-reduction" alternatives to combustible cigarettes, but it is not clear whether…
- Conditions
- Diabete Type 2, E Cigarette Use, Clinical Outcomes
- Trial name
- E-cig-DM (NCT07414355)
- Testing
- Change in smoking behavior after type 2 diabetes diagnosis
- Where
- South Korea
- Volunteers
- 133,320 people
- Sponsor
- Samsung Medical Center
Critical Incident
Feasibility Study of an Interactive Remote Supervising Platform for Critical Care: A Randomized Study
This study investigates the effectiveness of using Hololens2 for remote education and feedback in medical procedures, specifically central venous catheterization.
- Trial name
- NCT07861555
- Testing
- Hololens2(Microsoft), Face-to-face supervision
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Pain, Postoperative / Acute Pain
Opiranserin Injections PCA Regimens for Postoperative Pain
The purpose of this phase 2 study is to evaluate the efficacy and safety of PCA regimen of opiranserin (VVZ-149) injections in patients undergoing laparoscopic colectomy.
- Trial name
- NCT07821307
- Testing
- VVZ-149 Injections, Fentanyl
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Samsung Medical Center
Cancer Survivorship, Cardiovascular Disease
Routine LDL Exam For Cancer Survivors
This observational study will evaluate whether annual low-density lipoprotein cholesterol (LDL-C) testing is associated with improved cardiovascular preventive care and a lower risk of cardiovascular events among cancer…
- Trial name
- LDL Cancer (NCT07738250)
- Volunteers
- 1,294,726 people
- Sponsor
- Samsung Medical Center
Major Depression
Clinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory Complaints
To evaluate the efficacy of choline alphoscerate on improving symptoms related to depression, anxiety, and subjective memory complaints compared to placebo in patients with Major Depressive Disorder(MDD) accompanied with…
- Trial name
- CHOLDEPS (NCT05257902)
- Testing
- choline alphoscerate
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Postoperative Delirium
Remimazolam vs. Propofol: Impact on Postoperative Delirium in Neurosurgical Patients
The investigator aimed to evaluate the incidence of postoperative delirium after remimazolam-based total intravenous anesthesia (TIVA) compared to the propofol-based TIVA in patients undergoing neurosurgery.
- Trial name
- NCT06115031
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 696 people
- Sponsor
- Samsung Medical Center
Lung Cancer, Brain Metastasases
Annual Brain MRI Surveillance for Detection of Brain Metastasis in Patients With Lung Cancer
This retrospective observational study will evaluate the effectiveness of periodic brain magnetic resonance imaging surveillance for detecting brain metastasis in patients with lung cancer.
- Conditions
- Lung Cancer, Brain Metastasases, MRI, Surveillance
- Trial name
- NCT07646041
- Volunteers
- 229,323 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Pembrolizumab Plus Ramucirumab in Metastatic Gastric Cancer
1. Objective 1) Primary Objective: To estimate preliminary overall response rate (ORR) of combination therapy of Ramucirumab and Pembrolizumab in patients with metastatic gastric or GEJ adenocarcinoma 2)Secondary Objectives: To…
- Trial name
- NCT04632459
- Testing
- pembrolizumab plus ramucirumab
- Where
- 2 sites in South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Aortic or Mitral Valve Replacement, Valvular Heart Disease Patients
Association of Prosthesis Types for Aortic or Mitral Valve Replacement With Long-term Risk of Mental Disorders
Patients were enrolled if the patients aged 60 to 70 years who underwent surgical aortic or mitral valve replacement. The age range was restricted to 60 to 70 years to ensure comparability in surgical indications between…
- Trial name
- NCT07489313
- Volunteers
- 1,811 people
- Sponsor
- Samsung Medical Center
Chronic Stroke, Subacute Stroke
Safety and Efficacy of Hip Assist Powered Exoskeleton for Gait Training in Patients With Late Subacute and Chronic Stroke
The aim of this study is to evaluate the safety of gait training using a hip-assist powered exoskeleton. This will be assessed by collecting all device-related adverse events occurring during the entire intervention period, which…
- Conditions
- Chronic Stroke, Subacute Stroke, Exoskeleton
- Trial name
- brain disorder (NCT07353203)
- Testing
- gait assistance mode group, Resistance mode
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma, Portal Vein Thrombosis
Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion
This study is investigator initiated, single-institution, prospective, phase 2 open-label study to determine the efficacy and safety of combination therapy of atezolizumab/bevacizumab and proton beam therapy to portal vein tumor…
- Trial name
- NCT05625893
- Testing
- PBT and atezolizumab/bevacizumab
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Prospective Registration of Head and Neck Cancer
Head and neck cancers account for the sixth leading cause of cancers worldwide. The annual incidence of Head and neck cancers is more than 650,000 the patients each year.
- Trial name
- NCT02546895
- Testing
- chart review
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy
Development of a Remote Therapy Protocol for Upper Limb Function Enhancement in Children With Cerebral Palsy
The perpose of this study: Development and demonstration of a teletherapy protocol to improve upper limb function in children with cerebral palsy.
- Trial name
- NCT06272760
- Testing
- Home-based hand-arm bimanual intensive training (Tele-HABIT)
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center
Neoplasms
Mobile Application Using the PRO-CTCAE to Improve Patients' Participation in Symptom Management During Treatment.
This study aims to evaluate the effect of a mobile application system using the Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) to improve patients' participation in symptom…
- Trial name
- NCT04568278
- Testing
- ePRO-CTCAE application
- Where
- 2 sites in South Korea
- Volunteers
- 222 people
- Sponsor
- Samsung Medical Center
Breast Cancer Related Lymphedema
Clinical Feasibility of Mobile App-Based Self-Management for Breast Cancer-Related Lymphedema
The study evaluates a newly developed service that provides personalized self-management guidance based on evidence-based arm circumference measurements and resulting volume changes.
- Trial name
- NCT06922513
- Testing
- digital health (Application and Smart Measuring Tape)
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Dry Eye Disease (DED), Cataract
Rebamipide Versus Diquafosol and Cyclosporine for Perioperative Dry Eye in Cataract Surgery
The goal of this clinical trial is to compare the efficacy of 2% rebamipide monotherapy versus a combination therapy of 3% diquafosol and 0.05% cyclosporine for the management of dry eye disease in patients undergoing cataract…
- Trial name
- NCT07397936
- Testing
- Rebamipide 2% ophthalmic solution, Diquafosol 3% ophthalmic solution, Cyclosporine 0.05% ophthalmic solution
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease)
Lung Cancer Risk in Type 2 Diabetes With COPD: SGLT2 Inhibitors vs. Sulfonylureas
The goal of this observational study is to learn if a specific diabetes medicine can lower the risk of lung cancer in people with type 2 diabetes and chronic obstructive pulmonary disease (COPD).
- Conditions
- Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis)
- Trial name
- NCT07332156
- Testing
- SGLT2 inhibitor, Sulfonylureas (SU), DPP4 inhibitors
- Volunteers
- 21,692 people
- Sponsor
- Samsung Medical Center
Back Pain, Exoskeleton Device
Effects of Wearable Passive Back Support Suit on Back Pain in Caregivers
The physical demands of patient transport, including lifting and transferring patients, are significant contributors to the high risk of musculoskeletal disorders.
- Trial name
- back pain (NCT07333157)
- Testing
- wearable passive back support suit, traditional lumbosacral orthosis
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Diabetes Mellitus Type 2, Continuous Glucose Measurement
Effectiveness of Individualized Automatic Coaching Message for Glycemic Management and Depressive Symptom
This is a 12-week, single-center, randomized, prospective, confirmatory study of effectiveness of the individualized automatic coaching messages for glycemic management based on continuous glucose monitoring and depressive…
- Conditions
- Diabetes Mellitus Type 2, Continuous Glucose Measurement, Depressive Symptom
- Trial name
- NCT06769906
- Testing
- Individualized automatic coaching message for glycemic management and depressive symptom
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center