Clinical trials: sponsored by Semmelweis University
Atopic Dermatitis
Adjunctive Group Psychotherapy for Moderate-to-Severe Atopic Dermatitis: A Pilot Feasibility Study Comparing Two Interventions
Atopic dermatitis is a chronic inflammatory skin disease characterized by eczematous skin lesions and pruritus. This partially randomized, three-arm pilot feasibility study was designed to evaluate two adjunctive group…
- Trial name
- NCT07599878
- Testing
- Stress Management and Resilience Group Therapy (SRCST), Atopic Dermatitis-specific Cognitive Behavioural and Schema Mode Group Therapy (ADCBST), standard dermatological care
- Where
- Hungary
- Volunteers
- 32 people
- Sponsor
- Semmelweis University
Coronary Stent Restenosis
Optimal Treatment for Coronary Drug Eluting Stent In-stent Restenosis
The aim of this open label, randomized study is to compare the safety and efficacy of three different methods to handle coronary drug eluting stent (DES) in-stent restenosis (ISR).
- Trial name
- OPEN-ISR (NCT04862052)
- Testing
- Intravascular management of prior implanted coronary drug eluting stent restenosis
- Where
- 2 sites in Hungary
- Volunteers
- 108 people
- Sponsor
- Semmelweis University Heart and Vascular Center
HER2-negative Breast Cancer
Neoadjuvant Concomitant Modulated Electro-hyperthermia in HER2-negative Breast Cancer
The aim of this study is to investigate whether the application of concomitant modulated electro-hyperthermia in a neoadjuvant chemotherapeutic setting is beneficial for patients with HER2-negative, stage II-III breast cancer.
- Trial name
- NeoHTerMa (NCT05889390)
- Testing
- Oncotherm EHY-2030, Paclitaxel, Carboplatin
- Where
- Hungary
- Volunteers
- 71 people
- Sponsor
- Semmelweis University
Bone Loss, Tooth Movement
The Introduction of a Novel PAOO Technique
The aim of this study is to evaluate in a prospective, randomized, controlled clinical trail the effectiveness of preorthodontic piezotomy combined with a buccal bone augmentation (in other name periodontlly accelerated…
- Trial name
- NCT05264480
- Testing
- Bone augmentation with minimally invasive corticotomy (piezotomy), Bone augmentation without corticotomy
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Children, Only, Anesthesia
VR Based Simulation in the Preparation of Children for MRI - MRVR
The goal of this randomized controlled trial is to evaluate whether a virtual reality based preparation method can efficiently decrease the proportion of children requiring general anesthesia during MRI examinations.
- Trial name
- MRVR (NCT06132854)
- Testing
- VR, Booklet
- Where
- Hungary
- Volunteers
- 288 people
- Sponsor
- Semmelweis University
Periodontitis
Evaluation of Clinical and Radiological Outcomes Following the Treatment of Periodontal Intraosseous Defects Using Autogenous Tooth-derived Graft or Autogenous Bone Graft With Enamel Matrix Derivatives. A 12-month Randomized Controlled Clinical Trial.
This clinical study aims to evaluate and compare two different materials used to treat bone defects caused by periodontitis. Periodontitis is a chronic inflammatory condition that damages the supporting structures of teeth…
- Trial name
- NCT06991998
- Testing
- Autogenous bone graft with enamel matrix derivative, Autogenous tooth-derived graft with enamel matrix derivative
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Intrabony Periodontal Defect
Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF.
- Trial name
- NCT06768424
- Testing
- Guided biofilm therapy, Platelet Rich Fibrin, Minimally Invasive Surgical Technique
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Chronic Pain
Motivational, Movement and Self-Management Training for Adolescents in Pain
With this randomized controlled trial, we have three aims. First of all, to investigate underlying mechanisms that might contribute to the success of a physical activity focused self-management program in paediatric chronic pain.
- Trial name
- M3 Training (NCT05220384)
- Testing
- In-person Motivational Interview combined with Self-Management techniques, Video-based Motivational Interview combined with Self-Management techniques
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- Semmelweis University
Odontogenic Cysts, Odontogenic Keratocyst
Patient Specific Implants (PSIs) for the Decompression of Odontogenic Cysts
This study aims to assess the feasibility of the decompression of odontogenic cysts using Patient Specific Implants anchored subperiosteally using osteosynthesis screws.
- Trial name
- NCT06688851
- Testing
- Preoperative Cone Beam Computed Tomography (CBCT) scan, Cystostomy, Histology to confirm the initial diagnosis
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Semmelweis University
Esophageal Cancer (EsC)
Semmelweis Esophageal Cancer Study: Noninvasive Prognostic Parameters in Patients With Oesophageal and Esophagogastric Junction Cancer
The objective of this observational study was to gain a deeper understanding of the epidemiology of the disease in Hungary through a broad analysis of patients with new-onset esophageal-oesophageal-stomach junction tumors, and to…
- Trial name
- NCT06713993
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Odontogenic Cysts
Decompression of Odontogenic Cysts Using an Appliance Fabricated With a Fully Digital Workflow
The aim of this prospective case series is to present clinical results with cystostomy, decompression and final enucleation of odontogenic cysts using a decompression device fabricated with a full digital workflow and delivered…
- Trial name
- NCT05253261
- Testing
- Preoperative Cone Beam Computed Tomography (CBCT) scan, tooth removal and cystostomy, Decompression
- Where
- Hungary
- Volunteers
- 15 people
- Sponsor
- Semmelweis University
Impacted Tooth
Application of Surgical Templates in the Surgical Exposure of Impacted Canines
The first choice therapy in case of palatally impacted canines is their exposure and orthodontic eruption to improve facial esthetics and prevent pathologies associated with impacted teeth and Temporomandibular Joint Disorders.
- Trial name
- NCT05909254
- Testing
- Palatally impacted canine exposure using a surgical guide, Palatally impacted canine exposure using the conventional free.hand method
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Semmelweis University
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Tooth Decay
Comparing the Clinical Success of Two Different CAD/CAM Full Cuspal Coverage Onlays
This is a single-center, ten-year, randomized controlled, split-mouth clinical trial. A total of 164 adult patients requiring full-cuspal coverage onlays will be enrolled.
- Trial name
- CUSTOM (NCT07519382)
- Testing
- full cuspal covarage onlay
- Where
- Hungary
- Volunteers
- 164 people
- Sponsor
- Semmelweis University
Anaemia
ScvO2-Centered Optimisation of RED Blood Cell Transfusions
This clinical trial aims to personalise red blood cell transfusion strategies in the crtitically ill patients. The amount of transfusions needs to be minimised in order to prevent adverse events and organ dysfunctions linked to…
- Trial name
- SCORED (NCT07509203)
- Testing
- Measurement of central venous saturation
- Where
- 2 sites in Hungary
- Volunteers
- 600 people
- Sponsor
- Semmelweis University
Transcranial Magnetic Stimulation Repetitive, Schizophrenia
Theta-burst rTMS in Schizophrenia to Ameliorate Negative and Cognitive Symptoms
The major target of the study is to confirm the safety and efficacy of our augmented protocol of theta-burst TMS in schizophrenia.
- Trial name
- tbTMS_SCH21 (NCT05100888)
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Hungary
- Volunteers
- 76 people
- Sponsor
- Semmelweis University
Temporomandibular Disorders (TMD), Orofacial Pain
Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders
Dentists and physiotherapists have two options for treating these conditions: splint therapy and physiotherapy. Right now, the gold standard is individual physiotherapy, which contains manual therapy and active exercises too.
- Conditions
- Temporomandibular Disorders (TMD), Orofacial Pain, Temporo-mandibular Dysfunction, Temporomandibular Joint and Muscle Disorder
- Trial name
- NCT07474662
- Testing
- Individual physiotherapy, Group physiotherapy, Online physiotherapy
- Where
- 2 sites in Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Chronic Heart Failure
Biventricular or Left Bundle Branch Pacing to Assess the Effect of Cardiac Resynchronization Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation
In this prospective, randomized, multicenter, open-label interventional clinical trial, the investigators' aim to test the effect of Cardiac Resynchronization Therapy (CRT) in cases of new-onset and persistent Left Bundle Branch…
- Trial name
- BUDAPEST-TAVI (NCT07434193)
- Testing
- CRT implantation
- Where
- Hungary
- Volunteers
- 360 people
- Sponsor
- Semmelweis University Heart and Vascular Center