Clinical trials: sponsored by Seoul National University Hospital
Hepatocellular Carcinoma, Liver Cancer
TACE Using Idarubicin Versus Doxorubicin Chemoemulsion in Patients With Hepatocellular Carcinoma
Little is known about whether the types of chemotherapeutic agents affect the efficacy of transarterial chemoembolization in patients with hepatocellular carcinoma.
- Trial name
- IDADOX (NCT06114082)
- Testing
- IDA-TACE, DOX-TACE
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
Radioembolization as a Spearhead Treatment of Hepatocellular Carcinoma With Localized Portal Vein Tumor Thrombosis
The RESOLVE trial, an open-label, single-arm, multi-center study, aims to assess the efficacy and safety of ablative radioembolization using TheraSphere Yttrium-90 microspheres.
- Trial name
- RESOLVE (NCT06166576)
- Testing
- Ablative radioembolization
- Where
- 5 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
Radiation Major Hepatectomy to Selectively Treat Large Unifocal Hepatocellular Carcinoma
The RESCUE trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of ablative radioembolization using Yttrium-90.
- Trial name
- RESCUE (NCT06178198)
- Testing
- Ablative radioembolization using Yttrium-90 resin microspheres
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Atrial Fibrillation (AF)
Pacing of Left Bundle Branch Area and Atroventricular Node ablatIon in Patients With Symptomatic Atrial Fibrillation
This study aimed to compare the clinical outcomes of left bundle branch area pacing combined with atrioventricular node ablation and pharmacologic treatment optimized according to guidelines in patients with symptomatic atrial…
- Trial name
- PALLIATE-AF (NCT06699342)
- Testing
- Pacemaker implantation with Left bundle branch area pacing (LBBAP), Atrioventricular node ablation (AVNA), Pharmacologic therapy optimized for Atrial Fibrillation management
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma (HCC), Radioembolization
Building Evidence for Ablative Internal Radiation Therapy in Localized HCC Beyond the Up-To-7 Criteria
At four major centers in Korea, patients with hepatocellular carcinoma (HCC) that exceed the up-to-7 criteria yet remain locally confined will undergo ablative radioembolization using Yttrium-90 glass microspheres, guided by a…
- Trial name
- BEAT-UT7 (NCT06773845)
- Testing
- TheraSphere
- Where
- 8 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma (HCC)
Same-day Radioembolization for Large HCC
In patients who has no sign suggesting high lung shunt fraction (TIPS, hepatic vein invasion, hepatic vein enhancement on arterial phase, dysmorphic intratumoral vessel), planning angiography, MAA scan, and radioembolization are…
- Trial name
- ISTAR-01 (NCT06944483)
- Testing
- same-day radioembolization
- Where
- 4 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma (HCC)
Streamlining Radioembolization for Small HCC
In patients who has no sign suggesting high lung shunt fraction (TIPS, hepatic vein invasion, hepatic vein enhancement on arterial phase, dysmorphic intratumoral vessel, tumor size < 5cm), radioembolization is performed without…
- Trial name
- ISTAR-02 (NCT06979219)
- Where
- 5 sites in South Korea
- Volunteers
- 146 people
- Sponsor
- Seoul National University Hospital
Metastatic Colorectal Carcinoma (mCRC), Metastatic Liver Cancer
Streamlining Radioembolization for CCC and Metastatic Liver Cancer
TARE uses radioactive microspheres (20-60 μm), which are trapped in tumors due to abnormal vasculature, while normal liver sinusoids (≤15 μm) prevent their passage.
- Conditions
- Metastatic Colorectal Carcinoma (mCRC), Metastatic Liver Cancer, Cholangiocarcinoma
- Trial name
- ISTAR-03 (NCT07043387)
- Where
- 4 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Hypertension
Comparison of Office and Cuffless Ambulatory Blood Pressure-Guided Management in Patients With Hypertension
Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases, including stroke and myocardial infarction.
- Trial name
- CUFFLESS (NCT07770477)
- Testing
- Cuffless ambulatory blood pressure-guided management, Office blood pressure-guided management
- Where
- 9 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seoul National University Hospital
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Appetite, Binge Eating Behaviour
Effects of Home-Based Transcranial Direct Current Stimulation on Appetite
This randomized, placebo-controlled, double-blind, parallel-design study aims to evaluate the neurophysiological effects of home-based transcranial direct current stimulation (tDCS) on appetite in adults with binge eating…
- Conditions
- Appetite, Binge Eating Behaviour, Food Cravings
- Trial name
- NCT07757438
- Testing
- Active Home-Based tDCS
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colon Cancer
Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)
This study is a prospective, open-label, randomized phase 3 clinical trial. It aims to investigate if the early introduction of intensified chemotherapy (3 months of modified FOLFIRINOX) improves the 3-year disease-free survival…
- Trial name
- CLAUDIA (NCT05534087)
- Testing
- mFOLFIRINOX-FOLFIRI intensified chemotherapy, FOLFOX or CAPOX adjuvant chemotherapy
- Where
- 13 sites in South Korea
- Volunteers
- 236 people
- Sponsor
- Seoul National University Hospital
Wide Excision, Postoperative Pain
Local Anesthetic Infiltration for Pain Control After Orthopedic Wide Excision
This study evaluates whether injecting a local anesthetic mixture (ropivacaine, morphine, ketorolac, and epinephrine) under the skin at the incision site before wound closure reduces pain after orthopedic wide excision surgery…
- Trial name
- NCT07753629
- Testing
- Ropivacaine-Morphine-Ketorolac-Epinephrine-Cefuroxime Mixture, Cefuroxime-Saline Mixture
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest, Out-Of-Hospital
Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance
Identification of Causes and Risk Factors for Out-of-Hospital Cardiac Arrest through Development of Prediction Model and Novel Biomarkers Study Objectives: 1.
- Trial name
- CAPTURES (NCT03700203)
- Where
- South Korea
- Volunteers
- 5,340 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colon Cancer
Fluorescent Approach for Refined Endoscopic Marking With Clip Localization and Identification Procedure
Title of the Study Testing a Fluorescent Surgical Marker Clip for Tumor Localization in Minimally Invasive Colorectal Surgery Purpose of the Study This study aims to determine if a fluorescent surgical marker clip can accurately…
- Trial name
- FLARECLIP (NCT06714292)
- Testing
- Endoscopic Clipping, ICG injection
- Where
- 3 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Hospital
Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction
Distal Versus Conventional Radial Arterial Catheterization for Arterial Waveform Stability
During robot-assisted urologic surgery, both arms are often placed alongside the body and covered by surgical drapes. This position can make the arterial catheter difficult to access during surgery.
- Conditions
- Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction, Robotic Urologic Surgery
- Trial name
- DRA-stability (NCT07732296)
- Testing
- Conventional Radial Arterial Catheterization, Distal Radial Arterial Catheterization
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Pediatric Post-Intensive Care Syndrome, Critical Illness
Remote Exercise Program for Pediatric ICU Survivors
This pilot clinical trial aims to evaluate the feasibility and safety of a remote exercise intervention program designed to prevent pediatric post-intensive care syndrome (PICS-p) in children discharged from the pediatric…
- Trial name
- NCT07741942
- Testing
- Remote Exercise Intervention Program
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Cardiac Surgery
Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications
This trial aims to compare two intraoperative fluids, namely hydroxyethyl starch (HES) and balanced crystalloids in terms of major adverse kidney events after cardiac surgery.
- Trial name
- NCT07410988
- Testing
- Volulyte® (6% HES 130/0.4 in balanced solution), Crystalloid solutions
- Where
- 4 sites in South Korea
- Volunteers
- 1,292 people
- Sponsor
- Seoul National University Hospital
Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy
Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR)
This is a multicenter, prospective, open-label, randomized, investigator-initiated trial evaluating whether angiotensin receptor blocker (ARB) therapy improves clinical outcomes in patients with severe aortic stenosis (AS) and…
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic Stenosis
- Trial name
- ARBITAR (NCT07735130)
- Testing
- Angiotensin Receptor Blocker (ARB)
- Where
- South Korea
- Volunteers
- 632 people
- Sponsor
- Seoul National University Hospital
Food Addiction Tendency, Obesity
Effects of Semaglutide on Brain Dopamine Responses to Food Cues in Adults With Obesity and Food Addiction Tendencies
The goal of this clinical trial is to investigate how semaglutide affects the way the brain responds to food in adults with obesity and food addiction tendencies.
- Conditions
- Food Addiction Tendency, Obesity, Overweight
- Trial name
- NCT07732426
- Testing
- Semaglutide
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital