Clinical trials: sponsored by Shanghai Mental Health Center
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Antipsychotic Drug
Xingqi Daozhi Decoction for Antipsychotic-Induced Constipation
Antipsychotic medications are widely used to treat schizophrenia but may cause constipation, which can lead to abdominal discomfort, reduced quality of life, and poor treatment adherence.
- Trial name
- XQD-AIC (NCT07767526)
- Testing
- Xingqi Daozhi Decoction
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Mental Health Center
Amphetamine Use Disorders
Individualized Neuromodulation for the Core Clinical Features of Drug Addiction
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop tACS based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy…
- Trial name
- NCT06165198
- Testing
- Closed-loop tACS stimulation based on addiction-induced states
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Mental Health Center
Generalized Anxiety Disorder (GAD)
Multimodal Cohort Study of Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is a common mental health condition characterized by persistent and excessive worry that is difficult to control. It can affect sleep, daily functioning, work, and quality of life.
- Trial name
- MC-GAD (NCT07764211)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Mental Health Center
Amphetamine Use Disorders
Closed-loop tACS Modulation for the Core Clinical Features of Drug Addiction
Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes the effect of closed-loop tACS based on brain states
- Trial name
- NCT06454474
- Testing
- Closed-loop tACS stimulation based on addiction-induced states
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai Mental Health Center
Mental Health Literacy
Non-inferiority of Virtual vs. Traditional Methods in Adolescent Mental Health Literacy
The goal of this clinical trial is to determine whether a digital psychological literacy program delivered by an AI-powered virtual agent is non-inferior to traditional teacher-led instruction in improving mental health literacy…
- Trial name
- NCT07238842
- Testing
- Teacher-Led Psychological Literacy Instruction, Virtual Agent-Delivered Psychological Literacy Training
- Where
- China
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
High Risk, Depression / Major Depressive Disorder
Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders
This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and…
- Conditions
- High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder
- Trial name
- TRACE (NCT07744490)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder (MDD)
iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder
Major depressive disorder (MDD) is a common mental health condition characterized by substantial clinical heterogeneity and variability in treatment response.
- Trial name
- iMORE+ (NCT07735143)
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Stress, Anxiety
An ISO Principle-Based Music Intervention for Reducing Stress, Anxiety, and Depression
This study aims to evaluate the effectiveness of a music-based intervention, guided by the ISO principle, in reducing stress, anxiety and depression induced by work, family or others among adults.
- Conditions
- Stress, Anxiety, Depression in Adults
- Trial name
- ISO4SAD (NCT07055061)
- Testing
- ISO Principle Music Intervention, DUL Principle Music Intervention, ISO Principle Music Intervention with Waiting-list
- Where
- 2 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Meditation, Mindfulness
Investigation of Functional Brain Network in Altered Meditation State With Multimodal Neuroimaging
The purpose of this study is to investigate functional brain network in altered meditation state with multimodal neuroimaging.
- Trial name
- NCT05020301
- Testing
- external meditation guided audio, internal meditation guided audio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Extrapyramidal Symptoms, Drug-induced Parkinsonism
A Computer-Assisted Tool for Objective Assessment of Extrapyramidal Symptoms
This prospective, single-center observational study aims to develop and validate a computer-assisted tool for the objective quantitative assessment of extrapyramidal symptoms (EPS).
- Conditions
- Extrapyramidal Symptoms, Drug-induced Parkinsonism, Akathisia, Drug-Induced, Tardive Dyskinesia (TD)
- Trial name
- NCT07715994
- Testing
- Computer-Assisted Objective Assessment of Extrapyramidal Symptoms
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Abuse
Transcranial Magnetic Stimulation for Methadone Maintenance Therapy Combined With Methamphetamine Abuse
Repetitive transcranial magnetic stimulation (rTMS) has been used to treat opioid and methamphetamine addiction in previous studies, while no evidence was proved for patients methadone maintenance therapy with methamphetamine…
- Trial name
- NCT04264741
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Shanghai Mental Health Center
Tiletamine Use Disorder, Substance Use Disorder (SUD)
The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder
Participants diagnosed with tiletamine use disorder will be assigned to active or sham taVNS for 5 days. Clinical outcomes ( e.g., behavioral paradigms measures and clinical scales ) and physiological markers (e.g., EEG and ECG)…
- Conditions
- Tiletamine Use Disorder, Substance Use Disorder (SUD), Drug Craving
- Trial name
- taVNS-Tiletami (NCT07689981)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder
The Efficacy and Safety of ALIC/NAcc-DBS for Treatment-refractory OCD
The present study aims to explore the efficacy and safety of DBS targeted the combination of the anterior limb of internal capsule and nucleus accumbens (ALIC/NAcc-DBS) to refractory OCD, based on multicenter, randomized…
- Trial name
- NCT04967560
- Testing
- deep brain stimulation
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder
Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder
To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients…
- Trial name
- NCT06457230
- Testing
- Paired Associative Stimulation Targeting the Cerebellar-mPFC
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Anxiety Symptoms, Anxiety Disorders
TMS for Anxiety and Trauma-related Disorders
The present pilot study will apply accelerated intermittent theta burst stimulation (aiTBS) to a novel transcranial magnetic stimulation (TMS) target for anxiety derived via causal network mapping.
- Trial name
- NCT06475040
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Mental Health Center
Cognitive Deficit in Schizophrenia
Efficacy and Mechanisms of TUS on Cognitive Deficits in Schizophrenia: Based on the Hippocampal-Prefrontal Circuit
Cognitive deficit is a core symptom of schizophrenia related to poorer functional outcome. Prior studies indicated that abnormalities in the hippocampus-prefrontal circuit and glutamate/GABA imbalances may lead to cognitive…
- Trial name
- NCT06904092
- Testing
- Transcranial ultrasound stimulation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Negative Symptoms of Schizophrenia
Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia
Based on the current background and our previous studies, TUS has been proved that rTUS intervention could induce long-term potentiation like (LTP-like) plasticity and neuromodulate the brain cortex in schizophrenia patients.
- Trial name
- NCT05985993
- Testing
- low-intensity transcranial ultrasound stimulation (TUS)
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Shanghai Mental Health Center