Clinical trials: sponsored by Shanghai Mental Health Center
Post-traumatic Stress Disorder (PTSD)
The Efficacy and Safety of Temporal Interference Stimulation in the Treatment of Post-Traumatic Stress Disorder
This study aims to evaluate the efficacy and safety of Temporal Interference (TI) stimulation in treating patients with post-traumatic stress disorder (PTSD) and to explore its potential neural mechanisms using magnetic resonance…
- Trial name
- NCT07644338
- Testing
- TI stimulation device (nerviox-1000）
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Gambling Disorder
Effect of High-Intensity Transcranial Alternating Current Stimulation on Gambling Disorder: A Randomized Controlled Trial
The investigators assume that High-intensity transcranial Alternating Current Stimulation (HI-tACS) could improve gambling disorder patients' executive-control function by modulating abnormal neural activity, particularly…
- Trial name
- HITACSRCT-GD (NCT07228182)
- Testing
- HI-tACS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Mental Health During the Whole Life Cycle of Community Patients With Schizophrenia
Schizophrenia is one of the components of severe mental disorders. It has the characteristics of prolonged course, low cure rate, high recurrence rate and high disability rate.
- Trial name
- NCT05159349
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder (MDD
Multimodal Pharmacological Study of Clinical Cohorts for Major Depressive Disorder
This study focuses on the neurobiological changes in MDD patients with high suicidal risk during rapid antidepressant treatments, such as Esketamine and Electroconvulsive Therapy (ECT).
- Trial name
- NCT07602153
- Testing
- Therapeutic intervention
- Volunteers
- 130 people
- Sponsor
- Shanghai Mental Health Center
Alzheimer Disease (AD)
Study of Neural Stem Cell-Derived Exosomes in Moderate-to-Severe Early-Onset Alzheimer's Disease
This is an open-label, single-center, phase I clinical study in patients with moderate-to-severe early-onset Alzheimer's disease.
- Trial name
- NCT07554872
- Testing
- Neural Stem Cell-Derived Exosomes
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Effects of Gamified Rehabilitation on Cognitive and Psychosocial Outcomes in Inpatients With Schizophrenia
Schizophrenia is a severe and chronic mental disorder that profoundly impacts patients' psychological, social, and occupational functions. Cognitive impairment is a core symptom that severely limits daily living abilities.
- Trial name
- NCT07557368
- Testing
- Gamified Digital Rehabilitation
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
The Effect of Game-Based Intervention on the Cognition of Schizophrenia Patients
Schizophrenia is a common and severe mental disorder that imposes a significant burden on patients. Cognitive impairment can be regarded as one of the core symptoms of schizophrenia, which is prevalent among patients with…
- Trial name
- NCT07557381
- Testing
- Somatic Serious Games
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Shanghai Mental Health Center
Bipolar Disorder (BD), Healthy Control
An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion
Bipolar disorder (BD) has become a significant public health problem with complex clinical manifestations, difficult treatment, and poor prognosis.
- Trial name
- NCT07573839
- Testing
- This is an observational study with no intervention.
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Feeding and Eating Disorders
Web-based Guided Self-help CBT-E vs Online G-CBT-E for Binge Eating Behavior
Eating disorders with binge eating as the core feature include bulimia nervosa (BN) and binge eating disorder (BED). In recent years, the prevalence rate has increased rapidly, mostly among women, accompanied by emotional…
- Trial name
- NCT05873127
- Testing
- web-based guided self-help Enhanced Cognitive Behavioral therapy, online Enhanced Cognitive Behavioral therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Mental Health Center
Mood Disorders in Children and Adolescents
The Intervention Effect and Potential Neural Mechanisms of Music Therapy in Children and Adolescents With Mood Disorders
This study plans to combine questionnaires, scales, electrophysiological and neuroimaging methods to comprehensively evaluate the effectiveness of music therapy for children and adolescents with emotional disorders and NSSI, and…
- Trial name
- NCT06756698
- Testing
- conventional treatment plus music intervention, conventional treatment
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shanghai Mental Health Center
Depression - Major Depressive Disorder, Depression Disorders
Clinical Study of Compound Ciwujia Granules in the Treatment of Depression
The purpose of this clinical trial is to evaluate the therapeutic efficacy and safety of Compound Ciwujia Granules in treating depression disorder (heart-spleen deficiency syndrome).
- Trial name
- NCT07085143
- Testing
- Compound Ciwujia Granules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Anxiety Disorders
The Efficacy of an AI-Based Rehabilitation Treatment in Patients With Anxiety Disorders
The trail aimed to test the efficacy of AI-based rehabilitation treatment in patients with anxiety disorders. Specifically, the objective of this trial is to determine whether the AI-based rehabilitation combined with treatment…
- Trial name
- NCT07545070
- Testing
- AI-based rehabilitation treatment combined with standard treatment, Treatment as Usual (TAU)
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Shanghai Mental Health Center
Obessive-Compulsive Disorder
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Obessive-Compulsive Disorder (OCD) is frequently treatment-refractory and imposes a substantial burden on affected individuals. Although Exposure and Response Prevention (ERP) is widely regarded as the first-line intervention…
- Trial name
- NCT07484750
- Testing
- mindfulness based exposure therapy, Treatment as Usual (TAU)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Mental Health Center
Obsessive - Compulsive Disorder
Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD
The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area…
- Trial name
- NCT07480408
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Alcohol Use Disorder
Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Patients
The purpose of this research is to investigate the efficacy of transcranial temporal interference stimulation (tTIS) targeting the amygdala in patients with alcohol use disorder.
- Trial name
- NCT07472673
- Testing
- tTIS on Amygdala, 10 Hz
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder (OCD)
The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder
This study aims to evaluate the efficacy of Temporal Interference (TI) stimulation in treating patients with obsessive-compulsive disorder (OCD) and to explore its potential neural mechanisms using magnetic resonance imaging…
- Trial name
- NCT07113652
- Testing
- TI stimulation device (nerviox-1000）
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Insomnia, Psychiatric Disorders
A Multicenter Observational Study of Lemborexant on Insomnia Patients With Psychiatric Disorders
This study aims to evaluate the effectiveness and safety of lemborexant (a new dual orexin receptor antagonist) in the treatment of patients with mental disorders complicated with insomnia.
- Trial name
- NCT07417813
- Testing
- Lemborexant tablets
- Where
- 9 sites in China
- Volunteers
- 121 people
- Sponsor
- Shanghai Mental Health Center
Gaming Disorder
A Study to Evaluate the Effectiveness of Group Gaming Interventions for Individuals With Problematic Gaming Behavior and Gaming Disorder.
This is a randomized, parallel-group, two-arm study design registered with the Chinese Clinical Trial Registry. The study divides participants into an intervention group and a control group in the same ratio.
- Trial name
- NCT07363850
- Testing
- group gaming interventions
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Obsessive-Compulsive Disorder
Effect of SC-ICBT for Adults With OCD：A Three-Arm Randomized Controlled Trial
The goal of this clinical trial is to learn about the efficacy and cost-effectiveness of stepped-care Internet-based cognitive behavioral therapy (SC-ICBT) compared with Cognitive Behavioral Group Therapy (CBGT) and conventional…
- Trial name
- NCT05528224
- Testing
- stepped-care Internet-based cognitive behavioral therapy(SC-ICBT), Cognitive Behavioral Group Therapy (CBGT), conventional medical treatment (TAU)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Mental Health Center
Obsessive Compulsive Disorder (OCD)
Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT
This study is conducted to explore the efficacy and cost-effectiveness of stepped-care internet-based cognitive behavior therapy (sc-ICBT) with reduced support compared to cognitive-behavioral group therapy(CBGT), to identify the…
- Trial name
- NCT06659094
- Testing
- stepped-care Internet-based cognitive behavioral therapy(SC-ICBT), Cognitive Behavioral Group Therapy (CBGT), conventional medical treatment (TAU)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Shanghai Mental Health Center