Clinical trials: sponsored by Shanghai Zhongshan Hospital
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
Trends and Risk Factors of Adverse Cardiovascular and Cerebrovascular Events After Primary PCI
This single-center, ambispective cohort study will use real-world data from Zhongshan Hospital, Fudan University. About 8,000 patients aged 18 years or older with acute myocardial infarction (AMI) who underwent primary…
- Trial name
- TRACE-pPCI (NCT07833995)
- Testing
- Collection of baseline characteristics
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Renal Cyst
Multiphase CT Deep Learning for Bosniak II-III Renal Cysts
This retrospective study combine radiomics and deep learning models to predict malignancy in Bosniak II-III cystic renal masses, aiming for improving preoperative risk assessment and reducing unnecessary surgery for benign…
- Trial name
- NCT07833124
- Where
- China
- Volunteers
- 223 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiopulmonary Exercise Test Interpretation
AI-Assisted Anaerobic Threshold Interpretation in Cardiopulmonary Exercise Testing
This prospective randomized two-period crossover reader study will evaluate whether assistance from a frozen artificial intelligence model improves physicians' interpretation of the anaerobic threshold (AT) in cardiopulmonary…
- Trial name
- PACE-Reader (NCT07833137)
- Testing
- AI-Assisted Anaerobic Threshold Interpretation, Unassisted Cardiopulmonary Exercise Test Interpretation
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Borderline Resectable Pancreatic Cancer, High-Risk Resectable Pancreatic Cancer
Surufatinib in Combination With Iparomlimab and Tuvonralimab Injection and AG Chemotherapy for Neoadjuvant Therapy of HRPC or BRPC
This is a prospective, single-center, single-arm phase 2 study evaluating the efficacy and safety of neoadjuvant surufatinib plus iparomlimab and tuvonralimab injection and nab-paclitaxel/gemcitabine chemotherapy in patients with…
- Trial name
- ZSPAC-22 (NCT07833241)
- Testing
- Surufatinib Plus Iparomlimab and Tuvonralimab and AG Chemotherapy, Gemcitabine plus Capecitabine, Modified FOLFIRINOX
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer (NSCLC)
Perioperative Targeted Therapy in Resectable or Potentially Resectable Stage III Non-small Cell Lung Cancer With Rare Driver Mutations
This study evaluates the effectiveness and safety of targeted therapy given before and after surgery in patients with resectable or potentially resectable stage III non-small cell lung cancer with selected genetic alterations.
- Trial name
- NCT07829744
- Testing
- Surgical Resection
- Volunteers
- 190 people
- Sponsor
- Shanghai Zhongshan Hospital
Polycystic Ovary Syndrome
Efficacy of Mazdutide for Treating PCOS
The goal of this clinical trial is to learn the efficacy of Mazdutide in treating obese female adults diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06519656
- Testing
- Mazdutide
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Shanghai Zhongshan Hospital
Clinical Decision Support Systems, Cardiopulmonary Exercise Testing
Physician-Supervised GPT Assistance for Communicating Cardiopulmonary Exercise Test Results
Cardiopulmonary exercise testing requires clinicians to integrate multiple physiological measurements and explain their meaning, limitations, safety implications, and appropriate next steps.
- Trial name
- NCT07829731
- Testing
- Physician-Supervised GPT-Assisted Drafting, Physician-Only Drafting
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques
Positive- vs Negative-Pressure Extubation in High-Risk Patients
In the intensive care unit (ICU), weaning from mechanical ventilation and extubation are critical clinical goals. Successful extubation not only significantly shortens mechanical ventilation duration but also reduces the…
- Conditions
- Positive Pressure Extubation Techniques, Negative Pressure Extubation Techniques, High-risk Patients Prone to Extubation Failure
- Trial name
- NCT07829627
- Testing
- Positive-pressure extubation, Negative-pressure extubation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Zhongshan Hospital
Biliary Tract Cancer, Candonilimab
Candonilimab in Combination With LM-302 for Claudin 18.2 Positive-advanced Biliary Tract Cancer After Failure of Standard of Chemotherapy and PD1/PD-L1 Antibody
In this clinical study, we will evaluate the efficacy and safety of cardonilimumab (PD1 monoclonal antibody and CTLA-4 monoclonal antibody bisspecific antibodies) and LM-302 (Claudin18.2-ADC) in Claudin18.2-positive advanced BTC…
- Conditions
- Biliary Tract Cancer, Candonilimab, Claudin 18.2
- Trial name
- NCT05994001
- Testing
- cardonilizumab, LM-302
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Shanghai Zhongshan Hospital
Nonvalvular Atrial Fibrillation
TEE-Guided Versus CCTA-Guided Preprocedural Imaging for Left Atrial Appendage Closure
This prospective, open-label, multicenter randomized controlled trial will compare two preprocedural imaging assessment strategies in adults with nonvalvular atrial fibrillation who are scheduled to undergo percutaneous left…
- Trial name
- PEARL-LAAC (NCT07815119)
- Testing
- Transesophageal Echocardiography-Guided Preprocedural Assessment, Cardiac Computed Tomography Angiography-Guided Preprocedural Assessment
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Coronary Syndrome
OPtimization of Antiplatelet Therapy After the intervenTION of de Novo Coronary Artery Lesions With Drug-Coated Balloons
Coronary atherosclerotic disease remains one of the leading causes of mortality and morbidity worldwide. Although percutaneous coronary intervention (PCI) and drug-eluting stents (DES) implantation has significantly improved…
- Trial name
- OPTION-DCB (NCT07815106)
- Testing
- 1-month DAPT, 6-month DAPT
- Volunteers
- 2,122 people
- Sponsor
- Shanghai Zhongshan Hospital
Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma (OPSCC)
Rimegepant-Sensitized Neoadjuvant Chemoimmunotherapy for Oral or Oropharyngeal Squamous Cell Carcinoma
This study will evaluate whether adding rimegepant to standard neoadjuvant chemoimmunotherapy can improve treatment response in patients with primary or recurrent oral or oropharyngeal squamous cell carcinoma who are planned to…
- Trial name
- NCT07812467
- Testing
- Rimegepant, Tislelizumab, Nab-paclitaxel
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shanghai Zhongshan Hospital
Hepatocellular Carcinoma
Biomarker and Mechanism Study of Systemic Therapy in Unresectable HCC
The goal of this observational study is to evaluate the safety and efficacy of systemic therapies and identify predictive molecular biomarkers in patients with intermediate to advanced stage or unresectable hepatocellular…
- Trial name
- MUSE2 (NCT07786792)
- Testing
- Systemic therapy, Local therapy
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer (Diagnosis)
A Multicenter Prospective Study Evaluating the Diagnostic Performance of Femtosecond Laser Label-Free Imaging Combined With Artificial Intelligence for Predicting High-Risk Pathological Features in Lung Cancer
To investigate the diagnostic performance of Femtosecond Laser Label-Free Imaging combined with artificial intelligence for predicting high-risk pathological features in lung cancer
- Trial name
- NCT07799038
- Testing
- Femtosecond Laser Label-Free Imaging Combined with Artificial Intelligence.
- Volunteers
- 333 people
- Sponsor
- Shanghai Zhongshan Hospital
Lung Cancer (Diagnosis)
A Multicenter, Prospective Study on the Diagnostic Efficacy of Femtosecond Laser Label-Free Imaging Combined With Artificial Intelligence-Assisted Diagnosis for Rapid Diagnosis of Lung Cancer Surgical Specimens
To investigate the diagnostic efficacy of Femtosecond Laser Label-Free Imaging combined with artificial intelligence-assisted diagnosis for rapid diagnosis of lung cancer.
- Trial name
- NCT07794449
- Testing
- Femtosecond Laser Label-Free Imaging Combined with Artificial Intelligence
- Volunteers
- 335 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Transplanatation, Postoperative Complication
Avatrombopag for Severe Thrombocytopenia After Liver Transplantation: A Retrospective Cohort Study
Severe post-transplantation thrombocytopenia (platelet count <30×10⁹/L) occurs frequently after liver transplantation (LT) and is associated with increased bleeding risk, allograft dysfunction, and transfusion-related…
- Conditions
- Liver Transplanatation, Postoperative Complication, Severe Thrombocytopenia
- Trial name
- NCT07600905
- Testing
- Avatrombopag 20 mg Oral Tablet
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Cancer
An Exploratory Clinical Study of HRS-4642 in Combination With Immunotherapy and Chemotherapy for Pancreatic Cancer
To evaluate the safety and efficacy of HRS-4642 in combination with immunotherapy and chemotherapy in borderline resectable, locally advanced/metastatic pancreatic cancer
- Trial name
- NCT06938282
- Testing
- HRS-4642
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Non-Small Cell Lung Cancer
Study of Furmonertinib as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutant NSCLC
EGFR-TKI has firmly established itself as a first-line treatment for advanced lung cancer with EGFR-sensitive mutations, and the ADAURA study has added to its indications for use as postoperative adjuvant therapy in early- and…
- Trial name
- NCT05987826
- Testing
- Furmonertinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Primary Liver Cancer
Different Acupoint Stimulation for Postoperative Gastrointestinal Dysfunction in Primary Liver Cancer Patients
Brief Summary (Plain Language) The purpose of this clinical trial is to evaluate and compare the effects of four different intervention measures on preventing and managing postoperative gastrointestinal dysfunction in patients…
- Trial name
- NCT07781176
- Testing
- Acupoint application, TAES, Combined Intervention
- Volunteers
- 132 people
- Sponsor
- Shanghai Zhongshan Hospital
Critical Illness
ICCA-Based ICU Physiological State Space Monitor
Critically ill patients can deteriorate rapidly across multiple organ systems. Most intensive care unit (ICU) risk tools rely on measurements collected at a single time point and may not fully capture how physiology evolves or…
- Trial name
- NCT07773571
- Testing
- Multidimensional ICU Physiological State and Trajectory Features
- Where
- China
- Volunteers
- 60,000 people
- Sponsor
- Shanghai Zhongshan Hospital