Clinical trials: sponsored by Sheba Medical Center
Fasting Hyperglycemia
The Effect of Late Night Meals on Fasting Glucose in Type 2 Diabetes Patients
High fasting glucose is a very common problem in type 2 diabetic patients. The cause is probably glucose production by the liver, known as the "dawn phenomenon".
- Trial name
- NCT00986700
- Testing
- late night meal
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
MODY-2 Diabetes
The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family
Type 2 diabetes mellitus patients exhibit many glucose homeostasis abnormalities in different tissues and organs. Among the more important defects are disturbed hepatic glucose metabolism and defective pancreatic β-cell function.
- Trial name
- NCT01960231
- Testing
- OGTT
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
BRAIN MALIGNANCIES AFTER RADIATION THERAPY
Hyperbaric Oxygen Stimulation for Patients With Brain Malignancies After Radiation Therapy.
Radiotherapy is the mainstay of treatment for brain malignancies and is associated with significant neurotoxicity. Due to continuous increase in patient's survival, the long term risk for radiation-induced brain inflammation and…
- Trial name
- NCT01808625
- Testing
- HYPERBARIC OXYGEN STIMULATION
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Sheba Medical Center
Meconium
Detection of Meconium in Amniotic Fluid in Post Term Pregnancies
Meconium constitutes the bowel contents of the fetus and is normally expelled only after birth. However, it may be secreted into the amniotic fluid of 20% of all fetuses.
- Trial name
- NCT01429974
- Testing
- amniometer model po1
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Sheba Medical Center
Injury of Radial Artery
Feasibility and Outcomes of Repetitive Radial Approach
The purpose of this study is to assess the feasibility of performing repetitive coronary angiograms via the radial approach
- Trial name
- NCT02017054
- Testing
- Cath
- Where
- Israel
- Sponsor
- Sheba Medical Center
Pulmonary Disease
The Role of Endothelial Function Test in Risk Stratification for Early and Late Complications After Pulmonary Embolism
The aim of this study is to investigate the association between endothelial dysfunction, measured by RHI as assessed by the peripheral arterial tonometry method, and PE complications defined as re-event of PE or DVT, systemic…
- Trial name
- NCT03149471
- Testing
- Endothelial dysfunction test
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Inflammatory Bowel Diseases, Primary Immune Deficiency Disorder
Immunological Characteristics of Patients With PID and IBD
The investigators wish to characterize alterations in the architecture and function of immune cells in patients with a primary immunodeficiency that also develop inflammatory bowel disease.
- Trial name
- NCT03148028
- Where
- 2 sites in Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Complications Wounds
Novel Methods for Management of Complicated Wounds
Difficult to heal wounds are a common and complex medical problem, causing suffer to the patients and challenging medical, social and economic burden on the health system.
- Trial name
- NCT03074981
- Testing
- Combined TopClosure & Vcare Alpha
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Diabetic Nephropathies
Colchicine for Diabetic Nephropathy Trial
Forty patients with diabetic nephropathy will be treated with colchicine up to 2 mg, or placebo, for 18 months. A follow up will be performed after 12 additional months.
- Trial name
- CDNT (NCT02442921)
- Testing
- Colchicine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Healthy
The Effect of Load Carriage on Upper Limb Performance
Purpose: Quantify the relationship between brachial plexus deformations caused by backpack carriage and upper extremity performance.
- Trial name
- NCT02337998
- Testing
- load carriage
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Multiple Pregnancy
Transperineal Ultrasound for the Female Pelvic Floor in Women With Multiple Gestation
This trial studies the effect of pregnancies of multiple gestations (i.e. twins, triplets etc.) on the female pelvic floor with regards to the pregnancy itself and labor and delivery mode, by using transperineal ultrasound.
- Trial name
- NCT00790504
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pain
Effectiveness of of Therapeutic Currents in Clinical Dimension and Penetration Depth Dimension in Lower Back
Electrical stimulation therapy for pain reduction was performed already 2000 years ago. In recent years many studies had proved the effectiveness of electrical stimulation in pain management, tissue healing and muscle…
- Trial name
- NCT02384785
- Testing
- Transcutaneous Electric Nerve Stimulation
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Recovery From Bariatric Surgery
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery
Melatonin has sedative, hypnotic and analgesic properties that make it a good premedication agent before anesthesia and surgery.
- Trial name
- NCT02424071
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Non Alcoholic Fatty Liver Disease
Assessment of Endothelial Function in Patients With Non Alcoholic Fatty Liver Disease and the Impact of Statin Treatment
The aim of the current study is to evaluate the association of fatty liver severity and endothelial function in Non-Alcoholic Fatty Liver Disease (NAFLD) patients and to find the impact of statin treatment compared to usual care…
- Trial name
- NCT01987310
- Testing
- atorvastatin, lifestyle counseling
- Where
- Israel
- Sponsor
- Sheba Medical Center
HIV
Decrease of Neuropsychiatric Side Effects After Switching From Atripla to Eviplera
The aim of this prospective, open label study is to check for differences in neuropsychiatric and neurocognitive measurements among patients that will be switched from Atripla to Eviplera among 40 patients.
- Trial name
- DeepSwitch (NCT02447016)
- Testing
- Tenofovir disoproxil/emtricitabine/rilpivirine, Tenofovir disoproxil/emtricitabine/efavirenz
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Streptococcus Pneumoniae
PICR-b Nasopharyngeal S. Pneumoniae and Nasal S. Aureus Carriage Study
Objective: PCV effects on S. pneumoniae and S. aureus carriage in a population based study. The major specific aims: 1. To compare different PCV vaccination policies, by cross-sectional repeated surveillance of closely related…
- Trial name
- PICRcarriage (NCT03064620)
- Testing
- PCV
- Where
- Israel
- Volunteers
- 12,800 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Staphylococcus Aureus
Mother to Newborn Transmission of Staphylococcus Aureus and Dynamics of S.Aureus Carriage During the First Years Life
Staphylococcus aureus (SA) is a significant cause of community and hospital acquired infections. SA is carried by approximately 30% of healthy adults. Similar carriage rates have been reported in very young infants and newborns.
- Trial name
- NCT03064373
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Rett Syndrome
Open Label Trial of Triheptanoin (UX007) in Treatment of Rett Syndrome.
This is a single-center, exploratory, open-label study in 10 girls diagnosed with Rett Syndrome. The study will consist of the following 4 parts: Screening/Baseline run-in, Titration/Dose-Setting, Treatment, and Washout/Follow-up.
- Trial name
- UX007 (NCT03059160)
- Testing
- Tridecanoic Acid
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Acute Coronary Syndrome, STEMI
Chewing Ticagrelor Versus Prasugrel in ST-elevation Myocardial Infarction - A Platelet Reactivity Study
To examine the efficacy of chewing Ticagrelor versus Prasugrel in ST-elevation Myocardial Infarction (STEMI) patients on platelet reactivity.
- Trial name
- NCT03016611
- Testing
- Chewing Ticagrelor LD, Chewing Prasugrel LD
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Chewing Versus Traditional Oral Administration of Ticagrelor in STEMI Patients
To examine chewing versus traditional oral administration of ticagrelor in ST-elevation Myocardial Infarction (STEMI) patients on platelet reactivity.
- Trial name
- NCT02725099
- Testing
- Chewing Ticagrelor, Oral Ticagrelor
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center