Clinical trials: sponsored by Sheba Medical Center
Breast Milk, Composition, Microbiome
The Influence of Mother Nutrition on Breast Milk Microbiome
The research subject Health organizations around the world have determined that breastfeeding is the most critical source of nutrition for newborns in the first weeks and months of their lives.
- Trial name
- Breast Milk (NCT02332382)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Severe Hemophilia
Ex Vivo Laboratory Assays Application for Therapy Tailoring in Patients With Severe Bleeding Disorders
Therapy of patients with severe hemophilia (including hemophilia with inhibitors) and other severe bleeding disorders could be monitored and guided based upon special clotting assays , eg thrombin generation and…
- Trial name
- NCT02324517
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Tumor Motion, "Continuous Positive Airway Pressure"
Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy
This is a clinical study on patients to compare the effects of CPAP on lung volume diaphragm motion, heart position and tumor motion compared to free breathing.
- Conditions
- Tumor Motion, "Continuous Positive Airway Pressure", Lung Cancer, Breast Cancer
- Trial name
- NCT02324530
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Endometrial Receptivity Post Tamoxifen Exposure
Uterine Cavity Assessment and Endometrial Gene Expression in Tamoxifen Treated Breast Cancer Patients
The aim of this multi-center study is to assess the effects of Tamoxifen on the uterine cavity and endometrial abnormalities in young premenopausal women diagnosed with breast cancer.
- Trial name
- NCT02311647
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Myocardial Infarction, Cardiac Surgery
Evaluation of EarlySense Home Care Tele-monitoring Device
The aims of the present study are to evaluate the information obtained by the EarlySenese monitoring system and examine correlation of the obtained data and clinical events.
- Trial name
- NCT02318004
- Testing
- Home Monitoring
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Adhd
Psychostimulants Effects on Brain Functional Connectivity in Youth With Attention Deficit Hyperactivity Disorder
In the current study, we will administer three widely administered cognitive tasks while simultaneously measuring electroencephalography (EEG) in ADHD patients before and after methylphenidate immediate release (IR) treatment…
- Trial name
- NCT02318017
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Exercise Testing With Music Pacing
Music Pacing in Pediatric Exercise Testing
Study hypothesis: Music pacing improves the quality of exercise testing in children. Children tend to cycle in a non-constant pace during exercise testing, which might make the test less reliable.
- Trial name
- NCT01576913
- Testing
- Music listening
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility
Comparison of 2 Ovarian Stimulation Protocols for Women With Low Ovarian Reserve
The purpose of this study is to determine whether minimal ovarian stimulation for in vitro fertilization is superior to high dose stimulation. Number of mature eggs, number of embryos as well as pregnancy rates will be compared.
- Trial name
- NCT02128360
- Testing
- Letrozole, Gonadotropins, Gonadotropins
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Retinitis Pigmentosa, Glaucoma
Evaluation of Objective Perimetry Using Pupillometer
Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in…
- Conditions
- Retinitis Pigmentosa, Glaucoma, Visual Field
- Trial name
- NCT01021982
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heart Failure
Rehabilitation Program in Heart Failure With Preserved Ejection Fraction
The purpose of this prospective study is to determine whether comprehensive cardiac rehabilitation is superior to usual disease management in the treatment of patients with heart failure with preserved systolic function (HFpEF)…
- Trial name
- NCT01914315
- Testing
- Cardiac Rehabilitation, Internal Medicine
- Where
- 2 sites in Israel
- Volunteers
- 1,100 people
- Sponsor
- Sheba Medical Center
Cutaneous Leishmaniasis
Prospective Observational Study of Intralesional Treatment With Pentostam in Cutaneous Leishmaniasis Israeli Patients
Cutaneous leishmaniasis (CL) is endemic in Israel and is caused by Leishmania major or Leishmania tropica. CL is usually a benign disease and limited to the skin.
- Trial name
- NCT02281669
- Testing
- Pentostam
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Parkinson Disease
Dietary Modifications Effect on Continuous LCIG Infusion Outcomes in Patients With Advanced Parkinson&Apos;s Disease
To evaluate the role of dietary modifications of 3 different diets on clinical outcomes in patients with PD treated with Duodopa®.
- Trial name
- NCT02274324
- Testing
- different diets
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS
This study evaluates the effects of sustained-release oral dalfampridine in the treatment of upper limb deficits in people with multiple sclerosis (MS).
- Trial name
- NCT02259361
- Testing
- Sustained-release oral dalfampridine
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Polycystic Ovary Syndrome
Endobarrier Treatment in Women With PCOS
Women with Polycystic ovary syndrome (PCOS) experience multiple fertility treatments, a long treatment duration and a low pregnancy prevalence.
- Trial name
- EPCOS (NCT02255578)
- Testing
- Endobarrier treatment in PCOS, clomiphene citrate treatment
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Parkinson
Development of a Monitoring Set-up and Algorithm Using Functional MRI (fMRI) and EEG for Prediction of Response to Repetitive Deep Transcranial Magnetic Stimulation (rDTMS) for Patients With Parkinson's Disease
To characterize physiological biomarkers of positive response to rDTMS using EEG and functional MRI (fMRI) in patients with PD. To develop a set-up and algorithm for neurophysiological monitoring for PD patients using EEG and…
- Trial name
- NCT02249715
- Testing
- Brainsway Multiway deep TMS device (two channels)
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Brain Injury, Stroke
Using Tablets for Upper Extremity Rehabilitation Post Acquired Brain Injury
The purpose of the study is to test the effectiveness of training using novel tablet applications for hand function, compared to traditional hand exercises.
- Trial name
- TBL (NCT02136433)
- Testing
- Tablet - self exercise, GRASP self exercise
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Asymmetric Parkinson's Disease
A Double Blind Sham-controled Study to Evaluate the Influence of Low Frequency Repetitive Transcranial Stimulation (r-TMS) on Motor and Cognitive Measurements in Patients With Asymmetric Parkinson's Disease
The purpose of this study is to test the effects of low frequency deep rTMS using the novel H-coil on the motor, affective and cognitive deficits in patients with asymmetric Parkinson's disease (PD), to establish its safety in…
- Trial name
- NCT01367782
- Testing
- repetitive transcranial stimulation (r-TMS)
- Where
- Israel
- Volunteers
- 51 people
- Sponsor
- Sheba Medical Center
Depressive Disorder, Major
Ketamine Infusions for Major Depression Disorder
Ketamine has been safely used for induction and maintenance of anesthesia for decades and more recently has been used for chronic pain.
- Trial name
- Ketamie (NCT02219867)
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Chronic Diarrhea, Abdominal Pain
Antiparasitic Treatment for Returning Travelers With Chronic Diarrhea
Study hypotheses is that Antiparasitic therapy in patients with chronic diarrhea after travel to a developing country, with a negative stool findings, will be significantly effective in eliminating diarrhea and other…
- Conditions
- Chronic Diarrhea, Abdominal Pain, Bloating
- Trial name
- NCT01070277
- Testing
- Tinidazole and Albendazole
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Typhoid Fever
Typhoid Fever: Combined vs. Single Antibiotic Therapy
The current study goal is to examine the effect of Cephalosporins, Azithromycin and the combination of both on typhoid fever therapy in endemic population.
- Trial name
- NCT02224040
- Testing
- ceftriaxone, ceftriaxone and azithromycin, azithromycin
- Where
- Nepal
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center