Clinical trials: sponsored by Sheba Medical Center
Alk-positive Non-Small Cell Lung Cancer, ALK-inhibitor Treated
ALK Digital Pathology Outcome Predition, Multi Institutional, Restrospective Study
The Goal of this observational study is to develop an AI-driven pathologic image analysis-based classifier that can identify patients unlikely to significantly benefit from the currently utilized first-line ALK inhibitors…
- Trial name
- ALKDigPath (NCT06846736)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Pregnancy, Respiratory Aspiration of Gastric Content
Ultrasound Assessment of Gastric Volume in High-Risk Pregnant Women At Term
The risk of pulmonary aspiration of gastric contents remains a significant risk during anesthesia, especially in pregnant women, as they may often require surgery without having observed appropriate fasting.
- Trial name
- NCT06803225
- Testing
- Two-dimensional portable ultrasound unit with a low frequency (2-5 MHz) curved array transducer
- Volunteers
- 500 people
- Sponsor
- The Chaim Sheba Medical Center
Urolithiasis
Prospective, Randomized Trial Comparing Soft and Firm Ureteral Stents
The goal of this clinical trial is to evaluate whether ureteral stent type impacts stent-related symptoms and quality of life in patients undergoing ureteroscopy (URS) and stone lithotripsy for ureteral stones.
- Trial name
- NCT06749652
- Testing
- firm silicone stent insertion, Soft silicone ureteral stent insertion
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Metastatic or Locally Advanced NSCLC
Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy
This is an open-label, single-arm, phase 2a trial with a safety run-in cohort followed by a Simon two-step design expansion cohort, of two checkpoint blockage treatments and radiotherapy in the treatment of locally advanced or…
- Trial name
- CORAL-Lung (NCT05000710)
- Testing
- Durvalumab, Tremelimumab, Low dose irradiation
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Sheba Medical Center
Polycystic Ovary Syndrome, Microbial Colonization
Microbiome and Polycystic Ovaries
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women in reproductive age with an estimated prevalence of 5% to 19.5%.
- Trial name
- NCT04836910
- Testing
- Dietary recommendations, Oral contraceptive pills, Metformin
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Medical Abortion, Complete or Unspecified, Without Complication
Second Trimester Medical Abortion
The use of Mifepristone, an antiprogesterone, and Misoprostol together, has been shown to make the medial abortion process more efficient and reduce the induction-to-abortion interval by almost 50%.
- Trial name
- RAPM (NCT04160221)
- Testing
- 12 hours interval, 24 hours interval
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Surgery
vNOTES for Salpingo-oophorectomy
The aim of this study is to compare the common approach of laparoscopy for bilateral salpingo - oophorectomy to a new approach via transvaginal natural orifice transluminal endoscopic surgery (vNOTES).
- Trial name
- NCT04012710
- Testing
- Laparoscopy, vNOTES
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Contraception
Immediate Versus Delayed Initiation of Intrauterine System
Contraception for teenagers and young adults presents a huge challenge for the clinician as more than half of all unintended pregnancies occur as a result of inconsistent or discontinued use of contraceptives .
- Trial name
- JANESS (NCT03708809)
- Testing
- Intrauterine system, Alternative contraception to intrauterine system
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Crohn Disease (CD)
The Utility of Hand-held Ultrasound Devices to Detect Bowel Wall Inflammatory Activity in Crohn's Disease
One of the major obstacles in implementing intestinal ultrasound services for inflammatory bowel disease (IBD) patients relates to the costs of acquiring ultrasound (US) machines.
- Trial name
- NCT06686589
- Testing
- Intestinal ultrasound
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes Mellitus
EARLY FEASIBILITY STUDY: SAFETY AND EFFICACY OF PHOTON INFUSION SET
Study 1: The purpose of this study is to evaluate safety and efficacy of Photon infusion sets (PIS) with new PFAS-free cannula (catheter) in adult patients with Type 1 diabetes for up to 10 days and 6 hours.
- Trial name
- NCT06684561
- Testing
- PIS
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Chemotherapy-induced Peripheral Neuropathy
Integrative Medicine for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often debilitating complication of cancer treatments. There is presently no known treatment which can prevent the onset of CIPN, with treatment of existing…
- Trial name
- NCT03290976
- Testing
- Acupuncture, Multi-modality (Acupuncture "plus")
- Where
- Israel
- Volunteers
- 168 people
- Sponsor
- The Chaim Sheba Medical Center
Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disorders
Novel Locator-Positioner Device for Temporomandibular Joint Arthroscopy
The goal of this clinical trial is to evaluate a guide device (locator-positioner LOPO guide device) that is intended to aid the surgeon in temporomandibular joint (TMJ) arthroscopy.
- Conditions
- Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- TMJ-LOPO (NCT06520917)
- Testing
- Locator-Positioner (LOPO) Guide Device
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Malignant Lymphoma
TEAM (Thiotepa, Etoposide, Cytosar, Melphalan ) for AutoSCT in Lymphoma
Study is designed to explore whether the introduction of Thiotepa, to the pre autologous stem-cell transplantation (ASCT) conditioning will reduce toxicity and thus improve outcome following transplantation in up to 24 patients…
- Trial name
- TEAM (NCT03346096)
- Testing
- Thiotepa
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Inflammatory Bowel Disease
Immune Function in Offsprings of Females With Inflammatory Bowel Disease
1. To evaluate the immune response to vaccines in infants of IBD patients treated with anti-TNF medications during pregnancy compared to infants of IBD mother not treated with anti-TNF medications. 2.
- Trial name
- NCT02079441
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Child Behavior Disorders
Predicting Violent Outburst in Inpatient Pediatric Psychiatry Ward Using a Wearable Device.
The investigator will investigate the use of non-invasive wearable device physiological measures. this in order to predict aggression, and violence outburst in children under 12 years old, which are admitted at an inpatient…
- Trial name
- NCT06474702
- Testing
- 'Fitbit charge 4' 'smart-watch'-
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Williams Syndrome
Motor Deficits and Signal Conduction in Individuals With Williams Syndrome
The current study aims to validate basic research findings of abnormal conductivity and motor abilities from a mouse model in humans.
- Trial name
- NCT05430763
- Where
- Israel
- Sponsor
- Sheba Medical Center
Virtual Reality
Virtual Reality and Children With Type 1 Diabetes
For children with type 1 diabetes (T1D), pain and needle phobia can cause postponing of changes in insulin pump infusion sets and continuous glucose monitors, and thus worsen glycemic control.
- Trial name
- NCT05883267
- Testing
- Virtual reality glasses, Vocal-guided affective imagery
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Severe Mental Disorder, Schizophrenia
Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient
This study presents the development and validation of a unique Digital Experience Sampling Method (ESM) questionnaire specifically adapted for monitoring changes in the mental state of patients during psychiatric hospitalization.
- Conditions
- Severe Mental Disorder, Schizophrenia, Personality Disorders, Mood Disorders
- Trial name
- NCT06182787
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Major Depressive Disorder, Healty Controls
Inflammatory Markers as Predictors of the Efficacy of Electroconvulsive Therapy (ECT) in Major Depression Patients
Background: ECT is an effective treatment indicated for patients with treatment resistant depression. Although most patients display some degree of recovery, 32-52% do not respond or remit at all.
- Trial name
- ECT MDD (NCT06439797)
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- The Chaim Sheba Medical Center
Copd, End Stage Lung Disease
Health Coaching Telemedicine Program for Lung Transplant Candidates With End-stage Lung Disease.
Lung transplantation has become standard of care for selected patients with end stage pulmonary disease. While on the lung transplantation waiting list, patient health, emotional wellbeing and quality of life can deteriorate.
- Trial name
- HCTP (NCT06428513)
- Testing
- HCTP
- Where
- Israel
- Volunteers
- 56 people
- Sponsor
- Sheba Medical Center