Clinical trials: sponsored by Sheba Medical Center
Prostate Cancer
Phase II Study of RAD001 in a Neoadjuvant Setting in Men With Intermediate or High Risk Prostate Cancer
The mechanisms responsible for the development of hormonal refractory prostate cancer (HRPC) have been elusive. Genetic inactivation/loss of the PTEN tumor suppressor gene occurs in 30-60% of advanced prostate cancers and in 20%…
- Trial name
- NCT00657982
- Testing
- RAD001
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Sheba Medical Center
Glaucoma, Cataract
Diclofenac vs Dexamethasone in Combined Surgery
To study the effect of Diclofenac drops or Dexamethasone drops on combined surgery of trabeculectomy and cataract surgery.
- Trial name
- NCT00825864
- Testing
- diclofenac drops, dexamethasone sodium phosphate 0.1% eye drops
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Heart Failure
The Effects of Anodal Stimulation on Echocardiographic Outcome in Patients With Cardiac Resynchronization Therapy
To investigate the hemodynamic, inter and intraventricular desynchrony effects of anodal stimulation and triple site pacing compared with the usual dual site pacing by echocardiography and Tissue Doppler Imaging.
- Trial name
- NCT00825006
- Testing
- Triple site pacing mode
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Attention Deficit Hyperactivity Disorder, Autistic Disorder
Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities
The purpose of this study is to characterize the profile of executive functions and eye movements in several populations of children with developmental disabilities.
- Conditions
- Attention Deficit Hyperactivity Disorder, Autistic Disorder, Developmental Coordination Disorder
- Trial name
- NCT00716235
- Where
- Israel
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Bone Density
Bone Density of Newborn Infants to Mothers Treated With Selective Serotonin Reuptake Inhibitor (SSRI)
SSRI treatment in adults was found to decrease bone density. The use of SSRI among pregnant women with depression or anxiety is extendent and raising. The effect of bone density of the infants was not yet evaluated.
- Trial name
- NCT00818727
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
In Vitro Maturation of Immature Oocytes
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as…
- Trial name
- NCT00480337
- Testing
- In Vitro Maturation of immature oocytes
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Parkinson's Disease, Obsessive-Compulsive Disorder
Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD
The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive…
- Trial name
- NCT00790634
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Metabolic Syndrome, Diabetes
Lifestyle Intervention in Obese Arab Women
The study protocol aims to test the hypothesis that a lifestyle intervention program aimed to increase leisure-time physical activity and reduce body weight will improve the parameters of the metabolic syndrome and quality of…
- Trial name
- NCT00273572
- Testing
- Moderate Lifestyle Intervention, Intensive lifestyle intervention
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Bleeding
Thrombelastogram in Patients Receiving Antiplatelet Medication Undergoing Cardiac Surgery
Study Objective is to correlate the results of preoperative platelet mapping derived from modified TEG with clinically significant postoperative bleeding and consumption of blood products.
- Trial name
- NCT00778492
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Mucositis
Oral Zinc Therapy for the Prevention of Mucositis
Zinc is an intracellular mineral with important enzymatic cofactor activities for cell membrane stability, DNA and RNA structure. Zinc deficiency is associated with delayed wound healing and immune dysfunction.
- Trial name
- NCT00449592
- Testing
- Zinc
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Ischemic Heart Disease
Aspirin Resistance Following Coronary Bypass Surgery
Aspirin was proved to be the drug preventing vein grafts from closure and improving clinical outcome after coronary artery bypass surgery. It appears to be effective when being prescribed as early as first 48 hr.
- Trial name
- NCT00260377
- Testing
- Coronary artery bypass surgery
- Where
- Israel
- Sponsor
- Sheba Medical Center
Dyspareunia, Hypoactive Sexual Desire Disorder
Sexual Dysfunction and Dental Care
Evaluation of sexual functioning of patients at the Sexual Medical Center, at Sheba Medical Center in Israel. Sexual functioning shall be compared with their dental behavior. Hypothesis: a positive association will be found.
- Conditions
- Dyspareunia, Hypoactive Sexual Desire Disorder, Erectile Dysfunction, Vaginismus
- Trial name
- NCT00281372
- Volunteers
- 448 people
- Sponsor
- Sheba Medical Center
Ischemic Heart Disease
Levels of Circulating T Cells Expressing VLA-1 Collagen Receptors
The examination of the percentage of peripheral T cells carrying VLA-1 in ischemic heart disease patients. The hypothesis is that the percentage levels of cells carrying this integrin rise according to the severity of the…
- Trial name
- NCT00708838
- Volunteers
- 151 people
- Sponsor
- Sheba Medical Center
Pregnancy, Induction of Labor
Transcervical Foley Catheter With or Without Oxytocin for Induction of Labor
The purpose of the present study is to evaluate the possible benefit of concurrent IV Oxytocin infusion with trans cervical Foley catheter for pre-induction cervical ripening.
- Trial name
- NCT00684606
- Testing
- Oxytocin IV
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Thyroid Related Orbitopathy
Pascal Pascal Dynamic Contour Tonometer (DCT) Intraocular Pressure and Ocular Pulse Amplitude in Patients With Thyroid Related Orbitopathy: A Comparison to Goldmann Tonometer and to Muscles Characteristics on CT Scan
Thyroid related orbitopathy (TRO) is an autoimmune disease. Clinical features include: orbital pressure pain, ocular soft tissue swelling, muscle enlargement around the eyeball, eyelid retraction and bulging of the eye anteriorly…
- Trial name
- NCT00646295
- Testing
- To measure the IOP (with Goldmann and Pascal DCT tonometers) and OPA (with Pascal DCT) in primary and upright gazes
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Von Willebramd Factor
Levels of Von Willebrand Factor Multimers and VWF-Cleaving Protease (ADAMTS-13) in Preterm and Neonate
Von Willebramd Factor (VWF) is an adhesive glycoprotein synthesized by megakaryocytes and endothelial cells.VWF has a central role in primary hemostasis and is a critical ligand for platelets adhesion and aggregation (1, 2).VWF…
- Trial name
- NCT00701610
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Acquired Brain Injury
Checking the Usability of a Virtual Reality System in Children With Brain Injury
The purpose of this study is to check the usability of Virtual Reality (VR) Video Capture Projected System in children with acquired brain injury(ABI)and comparing their performance to the performance of normally developing…
- Trial name
- NCT00358865
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Osteoarthritis
Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study
Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage. Study protocol: Phase 1. 10 healthy volunteers, Phase 2.
- Trial name
- NCT00669201
- Where
- 2 sites in Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Healthy
Actigraphic Sleep Patterns in Newborns Delivered Via Vacuum Extraction vs. Partum Spontaneous and Cesarean Section
The development of regular sleep-wake cycle is an important factor of the newborn maturation and it has influence on behavior .Factor that may influence the process of the maturation of the sleep-wake cycle is the delivery…
- Trial name
- NCT00311142
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Neonatal Hypoglycemia
Early Breast Feeding and Glucose Levels in High Risk Newborns
Early breast feeding has shown to be important to mother-infant bonding and is associated with longer duration of breast feeding.
- Trial name
- NCT00332449
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center