Clinical trials: sponsored by Sheba Medical Center
Low Back Pain
Effectiveness of the Solio Alfa Care Plus Device in Treating Low Back Pain
Objectives: This double-blind, randomized, prospective, single-centre study evaluated the effectiveness of radiofrequency therapy by the SOLIO Alfa Cure Plus in the treatment of a non-specific low back pain (LBP) Methods…
- Trial name
- NCT06053034
- Testing
- Solio alpha cure plus
- Where
- Israel
- Volunteers
- 37 people
- Sponsor
- Sheba Medical Center
Home Hospitalization
Characteristics Associated With Duration of Home Hospitalization in Internal Department Versus Hospitalization in the Hospital in Internal Ward
According to data from the OECD - Organization for Economic Co-operation and Development, the hospitalization crisis in Israel's hospitals is getting worse, both in relation to previous years in the State of Israel and in…
- Trial name
- ARC (NCT06049875)
- Where
- 3 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Esophageal Cancer
CPAP for Esophageal Cancer With Radiotherapy
The goal of this clinical trial is to test the use of CPAP in patients with esophgaeal cancer undergoing radiotherapy. The main questions it aims to answer are: does use of CPAP decrease exposure of normal lung to radiation? does…
- Trial name
- TROS-7 (NCT06037902)
- Testing
- CPAP
- Where
- Israel
- Volunteers
- 44 people
- Sponsor
- Sheba Medical Center
Fertility Issues, Vaccine Adverse Reaction
COVID-19 Vaccine and Ovarian Reserve
As Israel is the first country to widely vaccinate its population using the mRNA vaccine against COVID-19, evaluating its influence on ovarian reserve is essential .
- Trial name
- NCT04748172
- Testing
- SARS-CoV-2 virus vaccines, AMH sampling, anti Covid-19 antibody levels (Serology)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Transcatheter Aortic Valve Replacement
Post-TAVI Coronary Access Study
Coronary access after trans-catheter aortic valve implantation (TAVI) remains a major challenge. With the evolution of TAVI procedure and the inclusion of lower-risk patients with aortic stenosis, future coronary access is an…
- Trial name
- PTCA (NCT04649190)
- Testing
- TAVI
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Ovarian Neoplasms, Carcinoma, Ovarian Epithelial
Pembrolizumab and Lenvatinib for Platinum- Sensitive Recurrent Ovarian Cancer
This is a study of pembrolizumab (MK-3475, KEYTRUDA®) in combination with lenvatinib (E7080) for the treatment of platinum sensitive recurrent ovarian cancer. Participants will receive pembrolizumab and lenvatinib.
- Conditions
- Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Neoplasm of Stomach, Ovarian Diseases
- Trial name
- NCT04519151
- Testing
- Pembrolizumab, Lenvatinib
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes
Low Carbohydrate Versus Mediterranean Diet in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to compare the effect of low carbohydrate diet versus Mediterranean diet on blood sugar values in adolescents with type 1 diabetes.
- Trial name
- NCT05872711
- Testing
- Low carbohydrate diet
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
IBS - Irritable Bowel Syndrome
Alcat Based Elimination Diet for the Treatment of Irritable Bowel Syndrome; a Randomized Double Blind Sham Control Trial
Irritable bowel syndrome (IBS) is the most common GI condition with global prevalence ranging between 10-20%. Although the exact cause is not known there are increasing insights concerning the possible multifactorial etiology…
- Trial name
- NCT05616429
- Testing
- Alcat based personal diet, Standard balanced diet, usual care
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Patient Satisfaction
Consented Unsedated Endoscopy in High Risk Patients That Require Anesthesiologist Observation During the Procedure
This study aim to examine the safety and feasibility of unsedated colonoscopy in patients with high risk for sedation (ASA score≥3).
- Trial name
- NCT05842720
- Testing
- un-sedated colonoscopies
- Where
- Israel
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Intra-Operative Injury - Other, Post Operative Hemorrhage
Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery
Prophylactic use of tranexamic acid to reduce intra and postoperative bleeding in primary sleeve gastrectomy procedures will be studied.
- Conditions
- Intra-Operative Injury - Other, Post Operative Hemorrhage, Tranexamic Acid
- Trial name
- PHORBBS (NCT03085394)
- Testing
- tranexamic acid
- Where
- Israel
- Volunteers
- 152 people
- Sponsor
- Sheba Medical Center
Pancreatic Cancer
Efficacy and Safety of PARPi to Treat Pancreatic Cancer
This is an open label, single arm, phase II trial of Olaparib for (PDAC) pancreatic ductal adenocarcinoma patients with BRCAness (breast cancer gene). All study subjects will receive Olaparib in a dose of 300 mg p.o twice daily.
- Trial name
- 10 (NCT02511223)
- Testing
- OLAPARIB
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Colorectal Neoplasms Malignant, Liver Metastases
Combined Immunotherapy and Radiosurgery for Metastatic Colorectal Cancer
A single institution study to evaluate the safety and tolerability of the combination treatment of nivolumab, ipilimumab, CMP-001 and radiosurgery in patients with metastatic colorectal cancer with liver metastases.
- Trial name
- NCT03507699
- Testing
- Liver radiation therapy, Nivolumab Injection [Opdivo], Ipilimumab Injection [Yervoy]
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
Hypothermia, Morbid Obesity
The Efficacy of External Warming During Laparoscopic Bariatric Surgery
External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated hot-air pump.
- Conditions
- Hypothermia, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03429205
- Testing
- No external heating used during surgery, External heating blanket used during surgery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Ulcerative Colitis
HF2 Therapy in the Treatment of Active Ulcerative Colitis
This is a phase I-II study with the herbal formulation (HF2) for treatment of active ulcerative colitis This will be a two-stage study: Stage 1 will comprise an open label single arm exploratory study of 10 active ulcerative…
- Trial name
- NCT03720002
- Testing
- HF2
- Where
- 2 sites in Greece, Israel
- Volunteers
- 52 people
- Sponsor
- Sheba Medical Center
Hodgkin's Lymphoma
Endothelial Function and IMT in Survivors of Hodgkin's Lymphoma
The aim of the proposed study is to assess endothelial function and IMT, as correlates of cardiovascular disease (CVD), in young adult Hodgkin's disease (HD) survivors, and to relate endothelial function to other risk factors…
- Trial name
- NCT00428688
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Sheba Medical Center
Non-Alcoholic Fatty Liver Disease, Steatosis of Liver
CT Liver Fat Fraction Quantification
Our aim is to develop an AI based tool to use ultra-low dose CT in two separate energy levels using a single-energy CT machine to quantify liver fat in individuals at risk for having non-alcoholic fatty liver disease (NAFLD)…
- Trial name
- NCT05676177
- Testing
- Ultra Low Dose CT, Fat quantification MRI
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Patient Satisfaction
Use of Virtual Reality Technology as a Sedation Replacement During Colonoscopy
A pilot non-randomized controlled study examined whether the use of VR technology can serve as an appropriate substitute for sedation in a colonoscopy examination.
- Trial name
- NCT05701566
- Testing
- virtual reality headset, colonoscopy with standard sedation.
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Malignant Melanoma Stage IV
Adoptive Cell Therapy Following a Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Melanoma Patients
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with lymphodepletion and high-dose interleukin 2 (IL-2) has demonstrated reproducible objective response rates of approximately 50 percent in…
- Trial name
- NCT03166397
- Testing
- Fludarabine, Cyclophosphamide, TIL
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Stroke, Acute
Health Disparities in Stroke Patients and Their Families: a Longitudinal Multicenter Study (HDSS)
The meeting point of the patient and his/her immediate family with the health care system is complicated and traumatic. While having to deal with medicalization geared towards providing evidence-based and cost-effective medical…
- Trial name
- HDSS (NCT03330652)
- Where
- 4 sites in Israel
- Volunteers
- 600 people
- Sponsor
- Sheba Medical Center
Psychotic Disorders, Cognitive Impairment
Cognitive Impairments in Psychotic Disorders
Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first…
- Trial name
- NCT05597579
- Testing
- DAPAR Tests (IQ equivalent test)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center