Clinical trials: sponsored by Sheba Medical Center
Pain Alleviation, Dilatation and Evacuation
Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation
A randomised control study aiming to examine whether inhaled N2O/O2 during cervical preparation for second trimester dilatation and evacuation with osmotic dilators (laminaria) alleviates pain and is superior to placebo.
- Conditions
- Pain Alleviation, Dilatation and Evacuation, Laminaria Placement, Nitrous Oxide
- Trial name
- NCT05579288
- Testing
- Nitrous oxide (N2O/O2), Oxygen (O2)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Type 1
Safety and Efficacy of Medtronic Extended Mio 30 Infusion Set
The purpose of this study is to evaluate the Extended Mio 30 infusion set (EM30IS) 7-day functioning compared to the regular Mio 30 infusion set (M30IS) 3-day functioning.
- Trial name
- NCT05544643
- Testing
- Medtronic Extended Mio 30 Infusion Set
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility
IVF Treatment in Women With Immature Oocytes in Previous Cycle
In standard IVF stimulation cycle,human chorionic gonadotropin (hCG) is usually used at the end of controlled ovarian hyperstimulation (COH) as a surrogate to only the luteinizing hormone (LH) surge.
- Trial name
- NCT02368964
- Testing
- GnRH agonist 0.2 mg + hCG 250 mcg, high dose hCG 500 mcg
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Questionnaires, Data Collection
Testing the Effectiveness of Two Hospitalization Alternatives Compared to Psychiatric Hospitalization (HOSP-ALT)
studies show that many of the people who were hospitalized in psychiatric wards had negative experiences of their stay there. These reports regarding patients' experiences have led in recent years to the development of several…
- Trial name
- HOSP-ALT (NCT05431231)
- Testing
- Outcome Questionnaire-45, Hopkins symptoms checklist - short form, Prodromal Questionnaire - Brief Version
- Where
- 4 sites in Israel
- Volunteers
- 180 people
- Sponsor
- Sheba Medical Center
IVF Treatment
Follicle Size and Oocyte Development
Studies have shown that the follicles greater in diameter was most likely to have a mature oocyte that was capable of fertilization and best suited for development into a high-quality embryo.
- Trial name
- AMJH (NCT03660813)
- Testing
- Follicle measurment, Ovitrelle ( Hcg 250 mcg), Decapeptyl ( GnRH Agonist 0.1 mg*2 )
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Uterine Scar From Previous Cesarean Delivery (Diagnosis)
Uterine Niche After Cesarean Section
In the past decade several articles have described a defect that can be seen on ultrasound at the site of cesarean delivery scar, known as a 'niche' .An incompletely healed scar is a long-term complication of cesarean delivery…
- Trial name
- AMSRM (NCT03787381)
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Thyroid Eye Disease, Eyelid Diseases
Tamsulosin for Thyroid Lid Retraction
The purpose of this study is to examine the effect of using Tamsulosin for treatment of eyelid retraction as part of thyroid eye disease.
- Trial name
- NCT04359979
- Testing
- Tamsulosin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Attention Deficit Disorder With Hyperactivity, Attention-Deficit Disorder in Adolescence
TM Meditation in Children With ADD/ADHD
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common developmental disorders experienced in childhood, with limited options for effective pharmacological treatment.
- Trial name
- NCT03817593
- Testing
- Transcendental Meditation (TM)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Alzheimer Disease
HAPPCAP-AD (Human-APPlication Combined Approach for Prevention of Alzheimer's Disease)
Currently, Alzheimer's disease (AD) has no cure putting prevention-strategies in the forefront for impeding the public health and personal consequences of this devastating disease.
- Trial name
- HAPPCAP-AD (NCT05256121)
- Testing
- AD Risk factors balance
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Type 1 Diabetes
Safety and Efficacy of DUO Extended Set: Combined Glucose Sensor and Infusion Set.
The study will follow subjects for 28 days while using an DUO extended infusion set combined with glucose sensor. the objective is to evaluate saftey and efficacy of the set in adult patient with type 1 diabetes.
- Trial name
- NCT04810780
- Testing
- DUO Extended Set
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Type 1 Diabetes
Meal Handling of Advanced Closed Loop Insulin Delivery.
The study will Compare meal related glycemic indices following 2 types of meal announcement: 1. Conventional assessment of carb content plus carb equivalence of proteins and fat 2.
- Trial name
- NCT04901143
- Testing
- Advanced hybrid closed loop system
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Sheba Medical Center
type1diabetes
Unannounced Meal Handling of Advanced Closed Loop Insulin Delivery in Monitored Condition
The study will follow participants for the periods of 3 months while using an advanced hybrid closed loop algorithm in free living conditions . Each period will have a different meal handling protocols.
- Trial name
- NCT04479826
- Testing
- Advanced hybrid closed loop system
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Sheba Medical Center
Diffuse Parenchymal Lung Disease
Ultra-Low Dose Computed Tomography For Diagnosis And Follow-Up Of Patients With Diffuse Parenchymal Lung Disease (DPLD)
The primary intention of this study is to determine the diagnostic performance of ultra-low-dose CT (ULDCT) in diagnosis and follow-up of diffuse parenchymal lung disease (DPLD).
- Trial name
- NCT04392726
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
To Assess Feasibility of the New Application
Feasibility of Transnasal ECHO for Identification of Parapharyngeal Internal Carotid Artery
Identification and preservation of internal carotid artery during endoscopic nasopharyngectomy in cases of malignancy is a main difficulty of this kind of surgery, especially when anatomy is distorted by previous radiation.
- Trial name
- NCT03838640
- Testing
- EPIQ 5
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Sheba Medical Center
Interstitial Lung Disease
Endobronchial Ultrasound Transbronchial Needle Aspiration Of Enlarged Mediastinal In Interstitial Lung Disease
The aim of this study is to assess the findings of mediastinal/hilar LN sampling by EBUS-TBNA in patients with non-sarcoidosis interstitial lung disease ( ILD) who demonstrate LN enlargement on chest imaging.
- Trial name
- NCT04331548
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Knee Pain Chronic
Outcome Measures of Pulsed Radiofrequency of the Genicular Nerves When Performed With and Without Concomitant Local Corticosteroid Administration
A single blinded randomized controlled trial to compare outcomes of patients with chronic knee pain receiving radiofrequency with or without corticosteroids.
- Trial name
- NCT04940832
- Testing
- pulsed radiofrequency modulation
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Ulcerative Colitis
Corticosteroids+5-aminosalicylic Acid Compared to Corticosteroids in the Treatment of Moderate-severe Ulcerative Colitis
The role of steroids in the treatment of ulcerative Colitis (UC) is well established, and recommended by professional societies.
- Trial name
- NCT01941589
- Testing
- oral 5-ASA+/-topical 5-ASA+IV corticosteroids / PO Methylprednisolone, corticosteroids only
- Where
- 10 sites in China, France and 5 more
- Volunteers
- 149 people
- Sponsor
- Sheba Medical Center
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Colon Cancer, Gastric Cancer
A Novel Patient Engagement Platform Among Patients With Gastrointestinal Malignancies
A randomized control trial to evaluate the feasibility of implementing a patient educational platform (PEP) for patients with gastrointestinal malignancies undergoing active chemotherapy treatment.
- Conditions
- Colon Cancer, Gastric Cancer, Pancreas Cancer, Rectal Cancer
- Trial name
- NCT04316078
- Testing
- patient engagement platform
- Where
- Israel
- Volunteers
- 126 people
- Sponsor
- Sheba Medical Center
Omega 3 Supplements During Pregnancy
The Effect of Alpha Linolenic Acid (ALA) Supplementation During Pregnancy
Omega-3 fatty acids are "good fats," and are among the most important nutrients lacking in Western diets today. The average person in developing countries consumes less than 100 mg of DHA daily.
- Trial name
- NCT03040856
- Testing
- Alpha Linolenic Acid, Omega 3 enriched diet ( DHA+EPA)
- Where
- Israel
- Sponsor
- Sheba Medical Center