Clinical trials: sponsored by Sheba Medical Center
Parkinson Disease
Assessment of Fluctuating Parkinson's Disease With Sensor-based Home Monitoring
The aim of this study is to implement home-based monitoring (HBM) using remote-capture wearable devices and patient reported outcomes (PROs) in a rather homogeneous subgroup of advanced Parkinson's Disease (PD) patients…
- Trial name
- NCT05247294
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Cell-Free Nucleic Acids
Study for Detection of Donor-derived Cell-free DNA After Renal Transplantation Using Devysers NGS-based Chimerism Assay.
The aim of this study is to evaluate highly sensitive quantitative tests for early molecular detection of graft rejection and associated immune response from liquid biopsies in the blood from patients undergoing renal…
- Trial name
- NCT05226936
- Testing
- Cell free DNA analysis
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
COVID 19
Daily Home Spirometry for Early Detection of Pulmonary Complications in Patients With COVID19
The aim of this preliminary study is to describe the potential decline in forced expiratory volume in 1 second (FEV1) or forced vital capacity (FVC) as measured by home spirometry in high-risk subjects infected with COVID-19.
- Trial name
- NCT04438863
- Testing
- home spirometry
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Sheba Medical Center
Lipid Profile in Pregnancy
Maternal Dietary Lipids and Omega 3 Essential Fatty Acids Profile in Pregnant Women at Term and Their Fetuses
This study aims to investigate the omega 3 lipid profile in pregnant women at term and their fetuses compared to non pregnant women , in normal western diet adding no supplementation
- Trial name
- OM3 (NCT02925013)
- Testing
- Blood sampling, Dietary- Normal western diet
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Bladder, Overactive, Parkinson Disease
Effect of Medical Cannabis for Non-motor Symptoms of Parkinson's Disease
Medical cannabis (MC) is a standard treatment in Israel to Parkinson's disease (PD) patients suffering from pain. Nevertheless, it is not known about MC effectiveness for other non-motor symptoms of the disease.
- Trial name
- NCT05106504
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Pulmonary Nodule, Multiple
Ultra-Low Dose CT Denoising for Lung Nodule Detection
We will perform an ultra low-dose CT (ULDCT) in addition to a regular chest CT scan for adult patients undergoing a clinically indicated chest CT.
- Trial name
- NCT03159377
- Testing
- Ultra low dose chest CT
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
Immune Response to COVID-19 Vaccine in Multiple Sclerosis Patients Treated With Teriflunomide and Alemtuzumab
Phase IV, 3-armed, prospective, open-label, single-center, Israeli study, examining the response to SARS-CoV-2 vaccination in 30 teriflunomide-, 10 alemtuzumab-treated patients, and 30 age-matched (for the teriflunomide group)…
- Trial name
- NCT05075499
- Testing
- COVID-19 vaccination
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Bariatric Surgery Candidate
Glycemic Index Variations In the Early Period Following Bariatric Surgery
The diverse community of gut microbes commonly referred to as the 'gut microbiome', is increasingly suggested to play significant roles in health and disease, and to affect even distant non-GI organs by metabolite signaling.
- Trial name
- NCT04263168
- Testing
- Continuous Glucose monitoring in the perioperative period
- Where
- Israel
- Sponsor
- Sheba Medical Center
Glaucoma, Glaucoma; Drugs
Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops
According to the American Academy of Ophthalmology's Preferred Practice Pattern on Primary Open Angle Glaucoma, patients should wait five minutes between administering topical drops for intra-ocular pressure reduction.
- Trial name
- NCT03220490
- Testing
- 5 minute interval between regular glaucoma drops - Long term, no interval between regular glaucoma drops - Long term, IOP reduction of Brimonidine and Timolol with time interval
- Where
- Israel
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Atherosclerosis
Characterization of Novel Lipoprotein Properties Associated With an Increased Risk to Develop Atherosclerosis
Objectives of Medical Research: Separation of LDL and HDL from blood samples of patients with high LDL and / or low HDL who have developed atherosclerotic disease with similar patients who have no evidence of atherosclerosis.
- Trial name
- NCT04487223
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Renal Colic
Evaluation of the Roll of IV Fluids in the Treatment of Renal Colic
A randomised controlled trial to evaluate the role of IV fluids in renal colic.
- Trial name
- NCT03529097
- Testing
- 0.9% Sodium-chloride, Optalgin, Voltaren, Morphine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Covid19, CBD
Synthetic CBD as a Therapy for COVID-19
The study aim to test proof of concept of CBD treatment for efficacy and safety in patients suffering with mild COVID-19 infection. The CBD will be delivered via oil droplets not containing THC, compared to placebo.
- Trial name
- NCT04686539
- Testing
- CBD
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Coronary Artery Disease
Comparison of Saphenous Vein Harvesting by Endoscopic Versus Open Conventional Methods
The aim of this study is to investigate the histological and immunohistochemical findings of the saphenous vein graft, to rule out endothelial damage as a direct result of manipulation or instrumentation by endoscopic and open…
- Trial name
- NCT03966222
- Testing
- Endoscopic vein harvest, Open vein harvest
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
B.E.D AND BULIMIA PATIENT, SMARTPHONE OWNER
Cognitive Behavioral Therapy Via a Smartphone Application on Bulimia Nervosa and Binge Eating Disorder Symptoms
Background: research show that cognitive behavioral therapy (CBT) is effective inreducing bulimia nervosa (BN) and binge eating disorder's (BED) symptoms.
- Conditions
- B.E.D AND BULIMIA PATIENT, SMARTPHONE OWNER, BASIC ENGLISH SPEAKER
- Trial name
- NCT02130037
- Testing
- application, psychotherapy
- Where
- Israel
- Sponsor
- Sheba Medical Center
Musculoskeletal Disorders, Musculoskeletal Pain
The Efficacy of Ergonomic Intervention in Preventing Musculoskeletal Disorders Among Women After Giving Birth
The woman's body undergoes many physiological changes during pregnancy, which can cause muscle weakness and postpartum joint instability.
- Conditions
- Musculoskeletal Disorders, Musculoskeletal Pain, Post Partum
- Trial name
- NCT04244279
- Testing
- Ergonomic workshop, Brochure, Videos
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Aortic Aneurysm, Thoracic
Impact of Anesthesia on the Dimension of the Ascending Aorta
The aim of this study is to evaluate the accuracy and reliability of intra-operative TEE after the induction of anesthesia when assessing proximal thoracic aorta diameters in a cohort of aortic aneurysm patients.
- Trial name
- NCT03431870
- Testing
- Trans-esophageal echocardiography
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation
Role of Exosomes Derived From Epicardial Fat in Atrial Fibrillation
Exosome plays an important role in the pathophysiology of the cardiovascular system. Since the field of cardiovascular exosome is still in its infancy, there are no available data regarding to its role in cardiac arrhythmias.
- Trial name
- NCT03478410
- Testing
- Epicardial fat biopsy
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Sheba Medical Center
Acute Anal Fissure
Effectiveness of Anal Enlargement by Dilators as a Therapeutic Physical Tool in Acute Anal Fissure
The treatment of anal fissure is mainly surgical. There are complications to this treatment, including damage to the inner anal sphincter and the appearance of fecal incontinence.
- Trial name
- NCT04828889
- Testing
- Anal dilators, lateral internal sphincterotomy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Major Depressive Disorder, Drug Abuse
Ketamine IV Classic Protocol : Five Years Follow up
Patients who suffer from MDD recieved ketamnie (2014-15) in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research.
- Conditions
- Major Depressive Disorder, Drug Abuse, Medications, Relapse
- Trial name
- NCT04824157
- Testing
- Non
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Sheba Medical Center
Cognitive Decline, Aging
Dietary Reduction of AGEs to Prevent Cognitive Decline in Elderly Diabetics
Basic science and observational human studies suggest that high conentrations of circulating Advanced Glycation End-products (AGEs) may promote cognitive decline in older adults.
- Conditions
- Cognitive Decline, Aging, Type 2 Diabetes
- Trial name
- NCT02739971
- Testing
- Low AGEs diet, Standard of care dietary guidance for Type 2 diabetes
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center