Clinical trials: sponsored by Shengjing Hospital
Breast Cancer
The Efficiency for Stage II-III HR+/HER2+ Early Breast Cancer Patient With Standard Neoadjuvant Therapy in Real World.
To observe the efficiency for patient with stage II-III HR+/HER2+ early breast cancer with standard neoadjuvant therapy, a retrospective, multicenter study in real world settings.
- Trial name
- NCT05263570
- Testing
- Standard Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shengjing Hospital
Breast Neoplasms
Efficacy and Safety of Pyrotinib Maleate Combined With ARX788 Neoadjuvant Treatment in Breast Cancer Patients
Next-generation Site-specific human epidermal growth factor receptor 2 (HER2)-targeting Antibody-drug Conjugate (ARX788) is an antibody-conjugated drug.
- Trial name
- NCT04983121
- Testing
- Next-generation Site-specific human epidermal growth factor receptor 2 (HER2)-targeting Antibody-drug Conjugate (ARX788)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Pyrotinib Maleate, Trastuzumab, SHR6390 and Letrozole in Combination for Stage II-III TPBC
NOAH study confirmed that trastuzumab combined with chemotherapy can significantly improve PCR compared with chemotherapy alone, and established the status of trastuzumab as a new adjuvant targeted therapy.
- Trial name
- NCT05228951
- Testing
- Pyrotinib maleate, dalpiciclib, Trastuzumab, letrozole
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shengjing Hospital
Plasma Cell Mastitis
A Single Arm Study of Traditional Chinese Medicine for Plasma Cell Mastitis
This is a single-center, single-arm, open-label trial evaluating the efficacy and safety of traditional Chinese medicine for plasma cell mastitis.
- Trial name
- NCT05530226
- Testing
- Traditional Chinese medicine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shengjing Hospital
General Anesthesia, Postoperative Pain
Preoperative Anxiety on Postoperative Outcome and Sleep Quality in Patients Undergoing Laparoscopic Hysterectomy
Sleep is a naturally occurring state of decreased arousal that is crucial for normal immune and cognitive function. Although surgery and anesthesia techniques have improved in recent years, sleep function and sleep cycles may…
- Conditions
- General Anesthesia, Postoperative Pain, Postoperative Sleep Quality, Preoperative Anxiety
- Trial name
- NCT04619979
- Testing
- patients undergoing gynecological surgery under general anesthesia
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Shengjing Hospital
Video-assisted Thoracoscopic Surgery, Inflammatory Reaction
Comparison of Inflammatory Cytokine Levels Between Single-port and Three-port Thoracoscopic Lobectomy in the Treatment of Non-small Cell Lung Cancersurgery on Perioperative Clinical Indexes、Inflammatory Reaction and Quality of Life Scores of Patients With Non-small Cell Lung Cancer
Many recent studies have shown that surgical trauma will result in an immunosuppressive state. Combined with the effect of surgical stress, it will often lead to metabolic changes, systemic inflammatory response, and other…
- Conditions
- Video-assisted Thoracoscopic Surgery, Inflammatory Reaction, Life Scores
- Trial name
- NCT05070026
- Testing
- uni-portal VATS group, three port VATS group
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shengjing Hospital
Stage II-III Breast Cancer
A Study of Immunotherapy Combined With Neoadjuvant Therapy Versus Neoadjuvant Therapy for Breast Cancer
This is a randomized, open label Phase II neoadjuvant study comparing the efficacy and safety of the combination of traditional herbal medicine for cancer immunotherapy and neoadjuvant therapy versus neoadjuvant therapy in…
- Trial name
- NCT05483439
- Testing
- cytotoxic chemotherapy (docetaxel or epirubicin or cyclophosphamide or carboplatin), anti-Her2 monoclonal antibody (Trastuzumab, Pertuzumab), traditional herbal medicine
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Pyrotinib Maleate, CDK4/6 Inhibitor and Letrozole in Combination for Stage II-III TPBC: a Phase II Trial
The emergence of CDK4/6 inhibitors has brought hope to breast cancer patients resistant to endocrine therapy. In the mouse model, pyrotinib maleate combined with CDK4/6 inhibitor exhibits higher anti-tumor activity than any…
- Trial name
- NCT04486911
- Testing
- Pyrotinib maleate, SHR6390, letrozole
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Clinical Study of Chidamide Combined With Chemotherapy in Neoadjuvant Treatment of HR+/ HER2-BC
Neoadjuvant therapy for HR+/HER2- breast cancer is dominated by anthracycline combined with paclitaxel chemotherapy. Aggressive neoadjuvant chemotherapy can only achieve pCR in about 10% of PATIENTS with HR-positive breast…
- Trial name
- NCT05400993
- Testing
- Chidamide
- Where
- 7 sites in China
- Volunteers
- 59 people
- Sponsor
- Shengjing Hospital
Dreaming, General Anesthesia
The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia
Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. 74% of awakenings from REM sleep resulted in recall of a dream, as compared with only 9% of awakenings from NREM…
- Trial name
- NCT05173688
- Testing
- Propofol
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Breast Neoplasms
Circulating Tumor Cell Detection in Patients With Luminal A Breast Cancer
The incidence of breast cancer in Chinese women has increased year by year, and luminal A breast cancer commonly occurs in early-stage and postmenopausal women.
- Trial name
- NCT04065321
- Testing
- PET-CT examination, Peripheral blood detection
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Shengjing Hospital
Sex Differences, Postoperative Sleep Quality
Sex Differences in Postoperative Sleep Quality and Inflammation
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men.
- Conditions
- Sex Differences, Postoperative Sleep Quality, Postoperative Pain, Inflammation Function
- Trial name
- NCT04608435
- Testing
- Video-Assisted Thoracoscopic Surgery
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Shengjing Hospital
Dreaming, General Anesthesia
Dreaming During Anesthesia and Anesthetic Depth in Elective Surgery Patients Under General Anesthesia
Dreaming is a common, enduring, and fascinating part of the anesthetic experience, but its cause and timing remain elusive. Patients typically report that they were dreaming during anesthesia, but the actual timing of anesthetic…
- Trial name
- NCT05357872
- Testing
- deep anesthesia depth, light anesthesia depth
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances
TEAS on Sleep Quality and POCD in Elderly Patients
Elderly patients are often considered as a high-risk population for major abdominal surgery due to reduced functional reserve and increased comorbidities.
- Conditions
- Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances, Postoperative Cognitive Dysfunction, Elderly Patients
- Trial name
- NCT04850196
- Testing
- TEAS, control group
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Prone Positioning CT Scan and Ultrasound Assessing Axillary Lymph Nodes in Patients With Breast Cancer Official Title: Evaluation of Axillary Lymph Nodes Using Prone Positioning Computed Tomography Scan and Ultrasound in Patients With Breast Cancer
The early diagnosis and evaluation of breast cancer is of great significance to its treatment and prognosis. Among the multiple factors affecting the prognosis, the degree of axillary lymph node metastasis is one of the most…
- Trial name
- NCT05346510
- Testing
- ALND Group
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shengjing Hospital
Polycystic Ovary Syndrome
CANA/Met in Non-diabetic Women With PCOS
Polycystic ovary syndrome (PCOS), which is associated with hyperinsulinaemia, hyperandrogenaemia, impaired glucose metabolism and aberrant adipokines production from the adipose tissue, is a heterogeneous reproductive and…
- Trial name
- NCT04973891
- Testing
- Canagliflozin combined with metformin, metformin
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Shengjing Hospital
Ultrasound Therapy; Complications, Transverse Diameter of Cricoid Cartilage
Ultrasound Measurements of Circular Cartilage Transverse Diameter
This study with children under 1 age of elective surgery as the research subjects, according to the cross diameter, compared with the traditional method of empirical catheter model, analyze the success rate, completion time of…
- Conditions
- Ultrasound Therapy; Complications, Transverse Diameter of Cricoid Cartilage, Endotracheal Intubation, Children
- Trial name
- NCT05273294
- Testing
- Portable color Doppler ultrasound system
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shengjing Hospital
Breast Neoplasms
Chidamide Combined With Exemestane (+/- Goserelin) Versus Neoadjuvant Chemotherapy in Patients of Stage II-III HR-positive/HER2-negative Breast Cancer
This is an open, multicenter, randomized controlled clinical study aimed to explore the efficacy and safety of chidamide combined with exemestane (+/- goserelin) versus chemotherapy in the neoadjuvant treatment of stage II-III HR…
- Trial name
- NCT05253066
- Testing
- Chidamide combined with exemestane (+/- goserelin), Chemotherapy with docetaxel plus epirubicin or change of chemotherapy regimen (at the discretion of the clinician)
- Volunteers
- 130 people
- Sponsor
- Shengjing Hospital
Breast Cancer
Axillary Lymph Node Treatment Guided by Naocarbon Tracing After Neoadjuvant Chemotherapy
For patients with early breast cancer with negative axillary lymph nodes, sentinel lymph node biopsy (SLNB) can largely avoid complications such as upper limb lymphoedema caused by axillary lymph node dissection (ALND).
- Trial name
- NCT05241119
- Testing
- SLNB, pALND, ALND
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital
Breast Neoplasms
DFS and QOL After Modified Radical Mastectomy vs. Expanded Mckissock Surgery for EIC of the Breast
Extensive intraductal carcinoma of the breast refers to a type of breast cancer in which ≥ 25% of ductal carcinoma in situ is present in invasive tumors and there is a scattered distribution of ductal carcinoma in situ (DCIS) in…
- Trial name
- NCT04052893
- Testing
- Expanded Mckissock surgery, Modified radical mastectomy
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Shengjing Hospital