Clinical trials: sponsored by Shirley Ryan AbilityLab
Acquired Brain Injury
Rewards Sensitivity After Brain Injury
A study measuring rewards sensitivity in individuals with acquired brain injury at an acute rehabilitation level.
- Trial name
- NCT06510023
- Testing
- Type of reward presented
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Amputation, Traumatic
Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
The goal of this study is to understand how providing power at the knee or ankle individually, or providing power at both the knee and ankle, impacts ambulation for K2 level transfemoral amputees.
- Conditions
- Amputation, Amputation, Traumatic, Amputation of Knee, Amputation; Traumatic, Limb
- Trial name
- NCT06433648
- Testing
- Ottobock CLeg4 + Ottobock foot, SRALAB Hybrid Knee + Polycentric Ankle, SRALAB Hybrid Knee + Passive Ankle
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation
Intuitive Control of a Hybrid Prosthetic Leg During Ambulation
The objective of this research is to determine the clinical benefits of an innovative and lightweight powered leg controlled using our intent recognition framework in laboratory and community environments.
- Trial name
- NCT04038151
- Testing
- Hybrid Leg, Prescribed Passive Prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Comparison of Two High-intensity Gait Training Interventions on Contraversive Pushing Behaviors in Individuals Poststroke
The purpose of this study is to investigate the effect of two high-intensity gait training interventions on contraversive pushing behaviors in individuals poststroke in the acute inpatient rehabilitation setting.
- Trial name
- NCT04550039
- Testing
- Body-weight-supported treadmill, Ekso Bionics EksoNR exoskeleton
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Acute, Gait Disorders, Neurologic
The Effect of Powered-Knee Exoskeleton Assist on Stair Climbing in Acute CVA
Hypothesis/Specific Aims: The purpose of this research study is to determine if using an exoskeleton during stair climbing training will result in an improved ability to walk and climb stairs in individuals affected by recent…
- Trial name
- NCT03264235
- Testing
- Keeogo, Traditional Stair Training
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Spinal Cord Injury, Spinal Cord Injuries
Spasticity and Functional Recovery After SCI
Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood.
- Trial name
- NCT06030531
- Testing
- Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation, Analysis of biomarkers
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Safety and Usability of the Honda Walking Assist Device (HWA) in the Home Environment
The purpose of this study is to verify the safety and validate the usability of the Honda Walk Assist (HWA) device in the home setting versus an exercise program without the device in a gym setting for individuals diagnosed with…
- Trial name
- NCT04380363
- Testing
- Honda Walk Assist (HWA) device, SRALab fitness center membership
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Safety and Feasibility of eGlove
The purpose of this study is to measure how cortical signals improve in stroke participants after passive hand stretching therapy from a robotic glove.
- Trial name
- NCT05345301
- Testing
- Event related desynchronization measurement
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Amyotrophic Lateral Sclerosis, Stroke
Telehealth Implementation of Brain-Computer Interface
Determine if Telehealth intervention can allow/empower a caregiver (who is untrained) to effectively implement and utilize a Brain-Computer Interface for communication with a participant who is "Locked in" following progression…
- Trial name
- NCT05951556
- Testing
- Use of BCI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Ischemic
Marker for Stroke Recovery
This study aims to develop a neurophysiological marker for post-stroke participants that predicts upper extremity motor recovery in response to a standard upper extremity rehabilitation protocol of task-specific training (TST).
- Trial name
- NCT05256368
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Age-associated Memory Impairment
TMS for Investigating Memory Facilitation
The aim of this study is to investigate the effects of Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) protocol on the memorization capacity of elderly individuals.
- Trial name
- NCT05462782
- Testing
- Transcranial Magnetic Stimulation (TMS) Cone Coil
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Osteoarthritis, Knee Osteoarthritis
The Impact of a Seated Compact Elliptical Trainer on Individuals With Knee OA
Exercise is considered the most effective, non-drug treatment for reducing pain and improving movement in patients with osteoarthritis.
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases
- Trial name
- NCT05857605
- Testing
- Exercise for Knee Osteoarthritis, Compact seated elliptical exercise machine- Cubii JR-1
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Robotic Exoskeleton With Functional Electrical Stimulation in Acute Spinal Cord Injury
The purpose of this study is to examine the effectiveness of mobility training using the Ekso robotic exoskeleton with functional electrical stimulation (FES) in persons affected by spinal cord injury; designated AIS…
- Trial name
- NCT04250688
- Testing
- Ekso Training with FES
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Aphasia
Studying Language With Brain Stimulation in Aphasia
The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.
- Trial name
- NCT05660304
- Testing
- Cortico-cortical paired associative stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia
Improving Electronic Written Communication in Aphasia
People with aphasia have difficulty with writing and often struggle to use electronic communication that connects people to one another.
- Trial name
- T-WRITE (NCT03773419)
- Testing
- Texting Intervention (T-WRITE), HandWriting Intervention (ORLA+WTG)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury
In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury.
- Trial name
- NCT05513911
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Shirley Ryan AbilityLab
Aphasia
Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)
Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing.
- Trial name
- NCT03773406
- Testing
- Offline tDCS-before therapy, Offline tDCS-after therapy, Online tDCS
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair
Our goal is to enhance repeated exposure to acute intermittent hypoxia (rAIH)/training-induced aftereffects on upper and lower limb function recovery in humans with chronic spinal cord injury (SCI).
- Trial name
- NCT03433599
- Testing
- Repeated exposure to acute Intermittent Hypoxia (rAIH), Normal Room Air, Upper-limb Training by Research Staff
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Spasticity After Spinal Cord Injury
Very often, people who have a SCI have difficulty doing things with their arms or hands as a result of muscle stiffness , or spasticity. Spastacity can cause problems performing even the simplest of everyday tasks.
- Trial name
- NCT04393922
- Testing
- Acoustic stimuli (Startle)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Aphasia, Stroke
The Intensive Comprehensive Aphasia Program (ICAP)
The purpose of this study is to conduct a randomized clinical trial that assesses the efficacy and cost-effectiveness of an Intensive Comprehensive Aphasia Program (ICAP), specifically focusing on the variable of intensity.
- Trial name
- NCT03514186
- Testing
- Speech and Language Therapy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Shirley Ryan AbilityLab