Clinical trials: sponsored by Sichuan University
Dental Anxiety
Effects of Aromatherapy on Anxiety and Pain During Dental Treatment in Adults
Dental anxiety is a common problem in dental care. The aim of this protocol is to evaluate the effect of orange and tea essential oil for the control of anxiety and pain in adults during dental treatments.
- Trial name
- NCT06347679
- Testing
- Aroma diffuser with single-note sweet orange essential oil, Aroma diffuser with single-note tea tree essential oil, Aroma diffuser with water
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Solid Tumor, Non Small Cell Lung Cancer
NAD+ Supplement（NMN）With Radioimmunotherapy in Advanced NSCLC
This is a phase I, single center (West China Hospital, Sichuan University) study aimed at investigating the safety and efficacy of NMN supplements combined with chemotherapy and radiation therapy for second-line and above…
- Trial name
- NMN (NCT06966583)
- Testing
- NAD supplement, Radiotherapy, Immunotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan University
Lung Cancer (NSCLC)
An Open-label, Single-arm Clinical Study of Stapokibart Injection in Combination with Tislelizumab Injection in Patients with Non-Small Cell Lung Cancer
This is a single-arm study evaluating the efficacy and safety of Stapokibart Injection in combination with Tislelizumab Injection in patients with driver gene-negative NSCLC who have failed prior PD-1/PD-L1 inhibitor therapy.
- Trial name
- NCT06883552
- Testing
- Tislelizumab Injection
- Volunteers
- 21 people
- Sponsor
- Sichuan University
Carcinoma, Esophagus Cancer
Tumor Antigen-sensitized DC Vaccine As an Adjuvant Therapy for Esophagus Cancer
The aim of this single center, single arm and prospective study is to explore the safety and efficacy of tumor antigen-sensitized DC vaccine in postoperative adjuvant treatment of esophageal cancer.
- Trial name
- NCT05023928
- Testing
- Tumor antigen-sensitized DC vaccine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Sichuan University
Epilepsy (treatment Refractory)
Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial）
Patent foramen ovale (PFO) is the most common cause of right-to-left shunt (RLS) in the adult heart, with a prevalence of approximately 25% in the general population.
- Trial name
- PREDICT-PFO (NCT06863350)
- Testing
- patent foramen ovale closure
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sichuan University
Stage IV NSCLC
Safety and Tolerability Evaluation of Sintilimab in Combination With Radiation in Stage IV NSCLC Patients
This pilot phase I trial aims to investigate the safety and tolerability of anti-programmed cell death-1 (PD-1) monoclonal antibody Sintilimab (also called IBI308) in combination with concurrent stereotactic body radiation…
- Trial name
- NCT03812549
- Testing
- Sintilimab, stereotactic body radiation therapy, Low Dose Radiotherapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Sichuan University
Gastric Cancer, Hepatocellular Carcinoma
Personalized DC Vaccine for Postoperative Cancer
The study is aimed to the test efficacy and safety of neoantigen-primed dendritic cell (DC) cell vaccine therapy for postoperative locally advanced gastric cancer, hepatocellular carcinoma, lung cancer and colorectal cancer, and…
- Conditions
- Gastric Cancer, Hepatocellular Carcinoma, Non-Small-Cell Lung Cancer, Colon Rectal Cancer
- Trial name
- NCT04147078
- Testing
- DC vaccine subcutaneous administration
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan University
Pancreatic Cancer, Adjuvant Therapy
Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy as an Adjuvant Therapy for Pancreatic Cancer
The aim of this single center, single arm and prospective study is to explore the safety and efficacy of Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy in postoperative adjuvant treatment of Pancreatic Cancer
- Trial name
- NCT06344156
- Testing
- Neoantigen Vaccine Plus Anti-PD1 and Chemotherapy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Sichuan University
Metastatic Prostate Cancer
Evaluate Safety, Whole-Body Distribution and Radiation Dosimetry in Metastatic Castration Resistant Prostate Cancer
A Study to Evaluate Safety, Whole-Body Distribution and Radiation Dosimetry of ZA-001, an Alpha-particle-emitting (At211) Radiopharmaceutical, in metastatic castration resistant prostate cancer
- Trial name
- NCT06359821
- Testing
- ZA-001
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Sichuan University
Lung Cancer, Non-Small Cell
A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC
This is a phase II study. All patients are stage IV non-squamas non-small cell lung cancer(NSCLC) with malignant pleura effusion, Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Trial name
- NCT06769295
- Testing
- AK112
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sichuan University
Small Cell Lung Cancer
Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC
This is a phase II study. All patients are treatment naive extensive stage small cell lung cancer(ES-SCLC), Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- Trial name
- NCT06769971
- Testing
- Ivonescimab, Cadonilimab, Etoposide
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan University
Esophageal Squamous Cell Carcinoma (ESCC), Immunotherapy
Low-Dose Involved-Field Radiotherapy Plus Immunochemotherapy for ESCC
The aim of this clinical trial is to evaluate whether low-dose involved-field radiotherapy combined with immunochemotherapy can reduce treatment-related adverse effects, enhance progression-free survival (PFS), and improve…
- Trial name
- NCT06603402
- Testing
- low-dose involved-field radiotherapy combined with immunochemotherapy
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Sichuan University
Advanced Solid Tumor
Dual-targeting CLDN18.2 and PD-L1 CAR-T for Patients with CLDN18.2-positive Advanced Solid Tumors
Claudin18.2(CLDN18.2) is a kind of integrin membrane protein in the tight junction between epithelium and endothelium, which is highly expressed in many solid tumors, especially in gastric cancer and pancreatic cancer.
- Trial name
- NCT06084286
- Testing
- Dual-targeting CLDN18.2 and PD-L1 CAR-T cells
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Sichuan University
Esophageal Squamous Cell Carcinoma (ESCC), Neoantigen-loaded Dendritic Cell Vaccine
Neoantigen Vaccines in Esophageal Squamous Cell Carcinoma
The aim of this clinical trial is to evaluate the efficacy and safety of consolidation therapy with a neoantigen-loaded dendritic cell vaccine (NeoDC-Vac) following radical chemoradiotherapy or chemoradiation-immunotherapy in…
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), Neoantigen-loaded Dendritic Cell Vaccine, Immune Checkpoint Inhibitors (ICIs)
- Trial name
- NCT06675201
- Testing
- neoantigen-loaded dendritic cell vaccine (NeoDC-Vac)
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Sichuan University
Peritoneal Carcinoma Metastatic, Pleural Effusion, Malignant
Dual-targeting HER2 and PD-L1 CAR-T for Solid Tumors
CAR-T therapy has achieved unprecedented success in hematological tumors in recent years, but the progress of CAR-T cells in the treatment of solid tumors is facing difficulties.
- Conditions
- Peritoneal Carcinoma Metastatic, Pleural Effusion, Malignant, HER2 Positive Malignancies
- Trial name
- NCT04684459
- Testing
- Dual-targeting HER2 and PD-L1 CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sichuan University
CLASS II DIVISION 1 MALOCCLUSION
Comparative Effect of Clear Aligner Mandibular Advancement and Twin Block Appliances in Class II Malocclusion
The goal of this retrospective observational study is to compare the effects of Clear Aligner Mandibular Advancement (MA) and Twin Block (TB) appliances in treating Class II malocclusion, a condition where the lower jaw is…
- Trial name
- NCT06609733
- Testing
- Twin block, Clear aligner with mandibular function
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Sichuan University
Dental Anxiety
The Effect of Aromatherapy for First Dental Visit Patients
First dental visit experience is strongly correlated with dental anxiety, the aim of this protocol is to explore the efficacy of olfactory aromatherapy for the reduce of dental anxiety and pain in first-visit patient.
- Trial name
- NCT06598904
- Testing
- Aroma diffuser with single-note lavender essential oil, Aroma diffuser with single-note orange essential oil, Aroma diffuser with deionized water
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Glioblastoma Multiforme
Tumor Treating Fields for Newly Diagnosed Glioblastoma: Two Emulated Trials With Chinese Multi-Hospital Based Real-World Data
The goal of this observational study is to learn about the effectiveness of Optune® (Tumor Treating Fields) in newly diagnosed glioblastoma (GBM) in China.
- Trial name
- NCT06346821
- Testing
- Optune® (Tumor Treating Fields)
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Sichuan University
Esophageal Cancer
Safety and Efficacy of Neoadjuvant Immunochemotherapy in Elderly Patients With Resectable Esophageal Cancer
We intend to conduct a prospective single-arm clinical study to explore the efficacy and safety of immunochemotherapy in neoadjuvant therapy in elderly patients with advanced esophageal squamous cell carcinoma.
- Trial name
- NCT06403878
- Testing
- Carboplatin, Nab paclitaxel, Sintilimab
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Sichuan University
Pancreatic Cancer
Oncolytic Virus Plus Anti-PD1 and Chemotherapy as Preoperative Therapy for Patients With BRPC/LAPC
The aim of this single center, single arm and prospective study is to explore the safety and efficacy of Oncolytic virus Plus Anti-PD1 and Chemotherapy as Preoperative therapy for Patients with Borderline Resectable and Locally…
- Trial name
- NCT06346808
- Testing
- Oncolytic virus Plus Anti-PD1 and Chemotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan University