Clinical trials: sponsored by Sun Yat-sen University
Respiratory Hypersensitivity, Perioperative Respiratory Adverse Events
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia
This randomized controlled study is to evaluate the effectiveness of inhaling penehyclidine hydrochloride in reducing perioperative respiratory adverse events in children at risk undergoing minor elective surgery.
- Conditions
- Respiratory Hypersensitivity, Perioperative Respiratory Adverse Events, Anticholinergics, Inhalation Therapy; Complications
- Trial name
- PEPSI (NCT06624696)
- Testing
- Penehyclidine hydrochloride, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 204 people
- Sponsor
- Sun Yat-sen University
Peripheral Venous Cannulation for Contrast-enhanced CT/MRI Examination, Peripheral Venous Access Establishment
Venipuncture Via Nurse-AI Collaboration
The goal of this clinical trial is to learn if AI-assisted site selection plus human-machine coordinated puncture improves the quality and safety of peripheral venous access for contrast-enhanced imaging in patients of all ages…
- Trial name
- NCT07854626
- Testing
- AI-assisted human-machine coordinated peripheral venipuncture, Conventional routine peripheral venipuncture
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nasopharyngeal Carcinoma
Penpulimab Combined With GP ± Anlotinib as Neoadjuvant Therapy in Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to explore the efficacy and safety of a combination of GP chemotherapy and Penpulimab ± Anlotinib in neoadjuvant therapy combined with Penpulimab in adjuvant therapy of locoregionally advanced…
- Trial name
- NCT05193617
- Testing
- GP+Penpulimab+Anlotinib, GP+Penpulimab
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Sun Yat-sen University
Bullous Keratopathy
Utilization of Residual Donor Tissue for Regrafting in Bullous Keratopathy After Corneal Transplantation
Postoperative endothelial cell loss following Descemet stripping endothelial keratoplasty (DSEK) remains a well-recognized clinical concern, with long-term follow-up demonstrating approximately 50% reduction in endothelial cell…
- Trial name
- NCT07855601
- Testing
- Endothelial keratoplasty using residual donor tissue
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Bladder Cancer
DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder Cancer
This is a prospective, open-label, single-arm exploratory clinical study evaluating the efficacy and safety of disitamab vedotin (RC48) plus toripalimab with cetirizine and mecobalamin in patients with locally advanced…
- Trial name
- NCT07853053
- Testing
- Disitamab Vedotin, Toripalimab, Cetirizine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dental Anxiety
Intranasal Dexmedetomidine for Severe Dental Anxiety: a Randomized Trial
Patients with dental anxiety only develop anxiety and fear about dental treatments. Patients with severe dental anxiety have difficulty cooperating with dental treatments, and can only complete dental treatments through general…
- Trial name
- NCT05500261
- Testing
- Dexmedetomidine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Recurrent Pregnancy Loss, Euthyroid With Thyroid Antibodies
Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-Ab
The goal of this clinical trial is to learn if combined treatment of levothyroxine and hydroxychloroquine would improve the live birth of euthyroid women with thyroid peroxidase antibodies and unexplained recurrent pregnancy…
- Trial name
- QT-LIFE (NCT06652113)
- Testing
- hydroxychloroquine and levothyroxine, Levothyroxine
- Where
- 2 sites in China
- Volunteers
- 796 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Head and Neck Squamous Cell Carcinoma (HNSCC)
Reduction of Postoperative Radiotherapy in Head and Neck Squamous Cell Carcinoma
To explore the control rate and quality of life of participants with late head and neck squamous cell carcinoma who have obtained postoperative pCR after cervical lymph node surgery with neoadjuvant chemotherapy combined with…
- Trial name
- REPORT-HNSCC (NCT06630780)
- Testing
- Head and Neck Cancers
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Unresectable Gallbladder Cancer
A Single-arm Phase II Clinical Study of the Efficacy and Safety of Camrelizumab Combined With GEMOX for Unresectable GBCs
The aim of this study was to evaluate the efficacy and safety of Camrelizumab combined with gemcitabine and oxaliplatin (GEMOX) for unresectable gallbladder cancer.
- Trial name
- NCT06423170
- Testing
- Camrelizumab plus GEMOX
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer Invasive
Long-Term Outcomes of Endoscopic-assisted vs Conventional Breast-conserving Surgery in Breast Cancer Patients After Neoadjuvant Therapy: a Randomized, Multicenter, Open Label, Non-inferiority Trial
With the title of "Long-Term Outcomes of endoscopic-assisted vs conventional breast-conserving surgery in breast cancer patients after neoadjuvant therapy: a randomized, multicenter, open label, non-inferiority trial", this study…
- Trial name
- NCT06716073
- Testing
- Surgery
- Where
- 2 sites in China
- Volunteers
- 804 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Melanoma (Skin) Stage IV
Cryoablation Combined With Hepatic Arterial Infusion of Iparomlimab and Tuvonralimab (QL1706), Intravenous Dacarbazine, and Oral Lenvatinib in Patients With Liver Metastases From Malignant Melanoma: a Single-arm, Phase II, Prospective Trial
To explore the efficacy and safety of cryoablation combined with hepatic arterial infusion of iparomlimab and tuvonralimab, intravenous dacarbazine, and oral lenvatinib in patients with liver metastases from malignant melanoma.
- Trial name
- Cryo-IA-Check (NCT07847359)
- Testing
- Cryoablation, Iparomlimab and Tuvonralimab, Dacarbazine
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer, Neoadjuvant Therapies
Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal Cancer (MODIFI-RC-II)
Most rectal cancers are microsatellite stable (MSS) or mismatch repair-proficient (pMMR) and respond poorly to PD-1 inhibitors. Radiotherapy can enhance tumor antigen release and improve responsiveness to PD-1 blockade in…
- Conditions
- Rectal Cancer, Neoadjuvant Therapies, Immune Checkpoint Therapy, Radiotherapy
- Trial name
- NCT06958432
- Testing
- Node-Sparing Radiotherapy plus Chemotherapy and PD-1 inhibitor, Conventional Radiotherapy plus Chemotherapy
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Advanced Hepatocellular Carcinoma (HCC)
HAI or IV of Adebrelimab, Combined With Bevacizumab and HAI of FOLFOX for Advanced Unresectable Hepatocellular Carcinoma
The purpose of this study is to evaluate the efficacy and safety of Adabrelimab (arterial or intravenous administration) combined with hepatic artery FOLFOX infusion chemotherapy and Bevacizumab as the first-line treatment of…
- Trial name
- HAIBrave-001 (NCT06737913)
- Testing
- HAI Adebrelimab, intravenous infusion (IV) of Adebrelimab (ADE), intravenous infusion (IV) of Bevacizumab (Bev.)
- Where
- 3 sites in China
- Volunteers
- 76 people
- Sponsor
- Sun Yat-sen University
Obesity & Overweight, Diabete Type 2
Traditional Chinese Medicine Fasting Therapy, Ketone Levels, and Metabolic Improvements
This is a retrospective study using existing medical records. The purpose is to learn how Traditional Chinese Medicine (TCM) fasting therapy affects metabolism.
- Conditions
- Obesity & Overweight, Diabete Type 2, Metabolic Syndrome
- Trial name
- NCT07840807
- Testing
- Traditional Chinese Medicine Fasting Therapy
- Where
- China
- Volunteers
- 1,149 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
Labor Onset
Maternal Oral Microbiota and Immune Signatures Associated With Spontaneous Labor Onset
This study investigates how the oral microbiome (the community of microorganisms living in the mouth) and immune system change around the time of spontaneous labor onset in healthy pregnant women.
- Trial name
- NCT07839364
- Testing
- None (Observational Study)
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Tic Disorder, Provisional Tic Disorder
Let It TiC in Childhood Provisional Eye Tic
Clarify the effectiveness and safety of "Reduced-Attention Intervention Therapy" in treating children with Provisional tic disorder （PTD） who mainly exhibit abnormal blinking behavior
- Trial name
- LETITTIC (NCT07838428)
- Testing
- Reducing Attentional Interventions Therapy Treatment, Continue with the previous treatment plan
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Uveitis
The Cohort Study of Uveitis Patients
This study intends to explore the epidemiology, pathogenesis, clinical manifestations, diagnosis and treatment of uveitis. This is a cohort study. The outcome of the study is the activity of inflammation and visual prognosis.
- Trial name
- NCT05727540
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Radiotherapy, PD-1 Inhibitor
Radiotherapy Combined With PD-1 Monoclonal Antibody and Capecitabine in the Treatment of Nasopharyngeal Carcinoma
This is a single-arm, multicenter, prospective, open-label phase II clinical trial of multi-target radiotherapy combined with PD-1 monoclonal antibody and capecitabine maintenance therapy treating oligometastatic nasopharyngeal…
- Conditions
- Radiotherapy, PD-1 Inhibitor, Capecitabine, Nasopharyngeal Carcinoma
- Trial name
- NCT05290194
- Testing
- SBRT radiotherapy + Conventionally fractionated radiotherapy, PD-1 inhibitor, Capecitabine
- Where
- China
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Dry Eye
Dry Eye Screening and Referral System
Dry eye is one of the most common ocular surface diseases. Its pathogenic factors are related to multiple etiology. Because of the complexity of the pathogenesis of dry eye, the diversity of related examinations, and the…
- Trial name
- NCT04413370
- Testing
- Dry eye diagnostic test
- Where
- China
- Volunteers
- 1,273 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Crohn Disease (CD), Intestinal Stricture
Endoscopic Stricturotomy Versus Balloon Dilation for Small Bowel Fibrotic Strictures in Crohn's Disease
This multicenter, open-label, randomized controlled trial aims to compare the safety and immediate effectiveness of endoscopic stricturotomy (ES) and endoscopic balloon dilation (EBD) for the treatment of small bowel fibrotic…
- Conditions
- Crohn Disease (CD), Intestinal Stricture, Intestinal Fibrosis
- Trial name
- NCT07833332
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
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