Clinical trials: sponsored by Sun Yat-sen University
Ophthalmology, Artificial Intelligence (AI)
Detection of Systemic Diseases Such as Hepatobiliary Diseases From Ocular Images Via Deep Learning
Oculomics is an emerging interdisciplinary field that deciphers multi-dimensional, high-throughput ocular data to predict, diagnose, and monitor systemic diseases and health span.In recent years, artificial Intelligence may…
- Conditions
- Ophthalmology, Artificial Intelligence (AI), Hepatobiliary Diseases, Systemic Diseases
- Trial name
- NCT07581925
- Testing
- Systemic diseases such as Hepatobiliary Disorders
- Where
- China
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Hepatocellular Carcinoma (HCC)
SBRT Versus Surgical Resection for Small HCC
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related incidence and mortality in China and represents a major public health challenge.
- Trial name
- NCT07381660
- Testing
- Stereotactic body radiotherapy (SBRT), Resection
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Sun Yat-sen University
Peritoneal Dialysis (PD)
Effect of IRPM-APD on Clinical Outcomes for PD Patients
To evaluate the impact of an integrated remote patient monitoring model on clinical, operational, and health-economic outcomes for patients receiving APD
- Trial name
- NCT07798024
- Testing
- Integrated remote patient monitoring (IRPM)
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Breast Cancer
Regional Radiotherapy Omission in Low-Risk Node Positive Breast Cancer
The purpose of this study is to determine whether certain patients can safely omit regional lymph node radiotherapy. These women must have hormone-sensitive, Her2-negative tumors, have 1-3 positive axillary nodes and have…
- Trial name
- NCT07179744
- Testing
- Omission of Regional Radiotherapy
- Where
- China
- Volunteers
- 635 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Metastatic Prostate Cancer
The Effect of Metformin in Patients With Newly Diagnosed mHSPC
The purpose of this study is to assess the effect of the addition of metformin to abiraterone on survival in patients with newly diagnosed metastatic hormone-sensitive prostate cancer.
- Trial name
- NCT04925063
- Testing
- Metformin
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Sun Yat-sen University
Chronic Subjective Tinnitus
Efficacy Analysis of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Therapy in the Treatment of Chronic Subjective Tinnitus
The goal of this multicenter, randomized, double-blind clinical trial is to compare two treatments for adults with chronic subjective tinnitus.
- Trial name
- NCT07794462
- Testing
- taVNS Combined With TMNMT
- Where
- 6 sites in China
- Volunteers
- 444 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Head and Neck Cancer, Neoadjuvant Therapy
Application of MRI Radiomics Features in Neoadjuvant Therapy of Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma is the sixth most common malignant tumor in the world. Neoadjuvant therapy, including neoadjuvant chemotherapy and immunotherapy, is recommended for patients with locally advanced head and…
- Conditions
- Head and Neck Cancer, Neoadjuvant Therapy, Immunotherapy, Chemotherapy
- Trial name
- NCT06755567
- Testing
- MRI-based radiomics-clinical model
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Metastatic Prostate Cancer
Prostate Cryoablation Combined With Metronomic Cyclophosphamide for Metastatic Prostate Cancer
The goal of this clinical trial is to explore whether androgen deprivation therapy combined with novel androgen receptor inhibitors, prostate cryoablation, and metronomic cyclophosphamide is superior to the current treatment…
- Trial name
- NCT06854250
- Testing
- Prostate cryoablation, Cyclophosphamide (CTX)
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Sun Yat-sen University
Cancer Patients
Effects of Different PICC Catheterization Methods: A Multicenter Randomized Controlled Trial
This study aims to compare the clinical effectiveness of three PICC (Peripherally Inserted Central Catheter) insertion methods: conventional non-tunneled PICC, one-needle tunneled PICC, and two-needle tunneled PICC.
- Trial name
- NCT07791719
- Testing
- Conventional Non-Tunneled PICC catheterization, One-Needle Tunneled PICC catheterization, Two-Needle Tunneled PICC catheterization
- Where
- China
- Volunteers
- 801 people
- Sponsor
- Sun Yat-sen University
Nasopharangeal Cancer, Distant Metastasis
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Salvage Locoregional Radiotherapy in De Novo Metastatic NPC
This phase III randomized trial evaluates PD-1 inhibitor plus chemotherapy followed by immediate versus salvage locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma.
- Trial name
- NCT07235319
- Testing
- Immediate locoregional radiotherapy, Salvage locoregional radiotherapy
- Where
- 5 sites in China
- Volunteers
- 260 people
- Sponsor
- Sun Yat-sen University
Patients Undergoing Major Laparoscopic Abdominal Surgery
Intrathecal Morphine for Postoperative Analgesia in Major Laparoscopic Abdominal Surgery, a IMPACT-Scope Trial
The goal of this clinical trial is to learn the clinical and cost effectiveness of intrathecal morphine (ITM) in addition to usual care as a postoperative pain relief strategy following major laparoscopic abdominal surgery…
- Trial name
- IMPACT-Scope (NCT06666985)
- Testing
- ITM + Usual Care
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Nasopharyngeal Cancinoma (NPC)
Reduced-dose vs Standard-dose Irradiation for Low-risk Clinical Target Volume in Nasopharyngeal Carcinoma.
To evaluate the locoregional control, survival rate, toxicity, and quality of life in patients with nasopharyngeal carcinoma treated with reduced prophylactic irradiation doses to the Low-Risk Clinical Target Volume (CTV).
- Trial name
- NCT07201337
- Testing
- Radiation Therapy
- Where
- 6 sites in China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-sen University
Ovary Cancer
RC48 in Combination With AK104 and Bevacizumab in OCCC
Disitamab vedotin (RC48) in combination with AK104 (PD-1/CTLA-4 bispecific) and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer: a single-arm, phase II, multicenter study (DAB OCC study)
- Trial name
- DAB (NCT06540729)
- Testing
- Disitamab vedotin in combination with AK104 and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Youth Mental Health, Psychological Distress in Adolescents and Young Adults
VIPeerAgent for Adolescent Mental Health
This three-arm parallel randomized controlled trial aims to evaluate the effectiveness of VIPeerAgent, a virtual peer support agent, in improving mental health outcomes among adolescents and young adults aged 14-25 years…
- Conditions
- Youth Mental Health, Psychological Distress in Adolescents and Young Adults, Early Intervention
- Trial name
- NCT07778758
- Testing
- Virtual Peer Agent Intervention, Human peer mentor
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
Radiotherapy Plus Nimotuzumab or Cisplatin in Nasopharyngeal Carcinoma
This is a phase III randomized clinical trial of definitive radiotherapy plus EGFR blocker nimotuzumab versus radiotherapy plus cisplatin(CCRT) for nasopharyngeal carcinoma (NPC) patients with favorable response to induction…
- Trial name
- NCT04456322
- Testing
- RT plus Nimotuzumab, RT plus Cisplatin
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Sun Yat-sen University
Acute Ischemic Stroke
OPtimizing REperfusion by Primary Intra-Arterial ThRomboLysis for Medium Vessel Occlusion
PEARL-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of primary intra-arterial thrombolysis in…
- Trial name
- PEARL-MeVO (NCT07137832)
- Testing
- Primary intra-arterial thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Colorectal Cancer (MSI-H), Molecular Residual Disease
Research on Colorectal Cancer Recurrence Monitoring and Individualized Treatment Based on MRD
This study aims to evaluate whether plasma molecular residual disease (MRD), assessed using circulating tumor DNA (ctDNA), can help optimize the duration of immunotherapy in patients with metastatic microsatellite…
- Trial name
- NCT07775950
- Testing
- Discontinue NA Treatment, Continued Immunotherapy, Observation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Ovarian Cancer, Platinum Sensitive Ovarian Cancer (PSOC)
Trastuzumab Rezetecan and Carboplatin ± Bevacizumab Versus Investigator's Choice Chemotherapy in Patients With Platinum-sensitive Recurrent Ovarian Cancer
This study is a randomized, open-label, controlled phase II clinical trial. It is planned to enroll 176 subjects with platinum-sensitive recurrent epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer…
- Trial name
- NCT07776171
- Testing
- Trastuzumab Rezetecan (SHR-A1811), Carboplatin, Bevacizumab
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Sun Yat-sen University
Comparative Nutrient Composition of Preterm and Term Human Milk
Comparison of Nutrient Content Between Preterm and Term Human Milk: a Systematic Review and Meta-analysis
The purpose of this study is to thoroughly evaluate nutrient disparities between preterm and term human milk.
- Trial name
- NCT07399405
- Testing
- observational study
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Non-metastatic Nasopharyngeal Carcinoma
Individualized Primary Clinical Target Volume Based on Margin Expansion for Nasopharyngeal Carcinoma
This is a non-inferiority, multicenter, randomized phase 3 trial aimed to evaluate whether primary clinical target volume (CTVp) delineation based on margin expansion provides comparable outcomes compared with the consensus CTVp…
- Trial name
- CTV-MARGIN-NPC (NCT07661771)
- Testing
- Comprehensive Therapy Based on Tumor Stage, IMRT with Primary Clinical Target Volume Based on Margin Expansion, IMRT with Consensus Primary Clinical Target Volume
- Where
- 7 sites in China
- Volunteers
- 568 people
- Sponsor
- Sun Yat-sen University
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