Clinical trials: sponsored by Sunnybrook Health Sciences Centre
Adult Diffuse Large Cell Lymphoma, Recurrent
DPX-Survivac and Checkpoint Inhibitor in DLBCL
This is a Phase 2 non-randomized, open label, uncontrolled, efficacy and safety study. Study participants will receive two priming doses of 0.5mL of DPX-Survivac 21 days apart and up to six 0.1ml maintenance injections every two…
- Conditions
- Adult Diffuse Large Cell Lymphoma, Recurrent, Adult Refractory Diffuse Large B-Cell Lymphoma
- Trial name
- SPiReL (NCT03349450)
- Testing
- DPX-Survivac, Pembrolizumab, Cyclophosphamide 50mg
- Where
- 6 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Tranexamic Acid Dosing for Major Joint Replacement Surgery
Over 1.7 million hip and knee replacements are performed every year worldwide. These surgeries are associated with high blood loss and transfusion rates. In older patients, the high blood loss can result in postoperative anemia.
- Trial name
- TXA-Dosing (NCT05075200)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Optimization of Prostate Biopsy - Micro-Ultrasound Versus MRI
OPTIMUM is a study designed to compare the ability of ultra-high resolution transrectal micro-ultrasound (microUS) and multiparametric MRI (mpMRI)/US fusion to guide prostate biopsy.
- Trial name
- OPTIMUM (NCT05220501)
- Testing
- Microultrasonography Targeted Biopsy, MRI Targeted Biopsy
- Where
- 22 sites in United States, Austria and 6 more
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Vascular Cognitive Impairment no Dementia
Memory and Antioxidants in Vascular Impairment Trial
This is a 24-week randomized, double-blind, placebo-controlled parallel group design study involving Vascular cognitive impairment-no dementia (VCIND) patients to evaluate the efficacy and safety of oral NAC supplementation…
- Trial name
- NCT03306979
- Testing
- N Acetylcysteine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Kidney Diseases, COVID-19
COVID-19 Vaccine Boosters in Patients With CKD
This study is a 12-month, four-arm parallel-group randomized control trial of Pfizer-BioNTech versus MODERNA COVID-19 (Corona Virus disease 2019)vaccine boosters in chronic kidney disease and dialysis patients with poor humoral…
- Trial name
- BOOST KIDNEY (NCT05022329)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine, MODERNA SARS-CoV-2 Vaccine
- Where
- 3 sites in Canada
- Volunteers
- 273 people
- Sponsor
- Sunnybrook Health Sciences Centre
Anemia, Iron Deficiency Anemia
Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia
Iron deficiency anemia is a global health problem and the most common cause of anemia worldwide. Patients with iron deficiency (ID) and IDA can present with a multitude of symptoms including fatigue, restless legs syndrome and…
- Trial name
- DEODO (NCT03725384)
- Testing
- Ferrous Sulfate 300Mg Tablet, Vitamin C 500Mg tablet
- Where
- 2 sites in Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ageing
Ageing and Acute Care Physicians' Performance
The proportion of older acute care physicians (ACPs) has been increasing. Ageing is associated with physiological changes and research investigating how such age-related physiological changes affect clinical performance is…
- Trial name
- NCT02683447
- Testing
- CRM Simulation
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Virtual Reality, Anesthesia
HoloLens: an Objective Alternative to the Operator's Memory
Neuraxial anesthesia has traditionally been a 'blind' technique relying on users' feel and skill, both are subjective, lack complete accuracy and influenced by patient's physique variations that are quite challenging, and lead to…
- Conditions
- Virtual Reality, Anesthesia, Epidural
- Trial name
- Hololens (NCT04028284)
- Testing
- HoloLens-guided epidural, US-guided epidural
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Glaucoma, Optic Neuropathy
Use of Bevacizumab in Trabeculectomy Surgery
When a patient with glaucoma who has a pressure that is too high and causing damage to their vision, despite receiving the maximum amount of medication that can be tolerated, the decision is made to have glaucoma surgery.
- Conditions
- Glaucoma, Optic Neuropathy, Fibrosis
- Trial name
- NCT01166594
- Testing
- Bevacizumab, Control
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pancreas Cancer, Pancreas Disease
Intra-operative Application of HEMOPATCH to the Pancreatic Stump to Prevent Post-operative Pancreatic Fistula Following Distal Pancreatectomy
Despite improvements and advances in pancreas surgery, about 30-35% of patients who have pancreas surgery develop a type of complication called a pancreatic fistula.
- Conditions
- Pancreas Cancer, Pancreas Disease, Pancreas Adenocarcinoma, Pancreas; Fistula
- Trial name
- PATCH-DP (NCT03410914)
- Testing
- Hemopatch
- Where
- 7 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Sunnybrook Health Sciences Centre
Head and Neck Neoplasms
Development and Evaluation of Rehabilitation Consult for Survivors of Head and Neck Cancer
Although evidence exists to support cancer rehabilitation, services are fragmented and rehabilitation professionals are consulted infrequently and often long after treatment ends, when chronicity of problems limits the impact of…
- Trial name
- HNC-RC (NCT02836769)
- Testing
- Rehabilitation Consult (RC)
- Where
- 2 sites in Canada
- Volunteers
- 35 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Hypofractionated Accelerated Radiotherapy for Low Risk Localized Prostate Cancer
The purpose of this study is to determine the safety and efficacy of a short course of radiotherapy (35 Gy / 5 fractions / 29 days) for the treatment of low-risk prostate cancer.
- Trial name
- pHART3 (NCT01578902)
- Testing
- Stereotactic ablative body radiotherapy
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Sunnybrook Health Sciences Centre
Twin Pregnancy
The Twin Birth Study: A Trial Comparing Planned Vaginal Birth to Elective Caesarean Section of Twins
For twin pregnancies at 32-38 weeks gestation, where twin A is head down, does a policy of planned caesarean section (CS) lower the likelihood of death or serious illness, during the first 28 days after birth, compared to a plan…
- Trial name
- NCT00187369
- Testing
- Method of Delivery
- Where
- Canada
- Volunteers
- 2,804 people
- Sponsor
- Sunnybrook Health Sciences Centre
Nausea, Vomiting
Aprepitant and Granisetron for the Prophylaxis of Radiation Induced Nausea and Vomiting - A Pilot Study
The primary objective of this pilot study is to examine the efficacy of Aprepitant given in combination with Granisetron for the prevention of delayed-phase RINV in 84 patients receiving a single 8Gy of moderately emetogenic…
- Trial name
- NCT01183481
- Testing
- Aprepitant, Palliative radiation therapy, Granisetron
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Sunnybrook Health Sciences Centre
Mental Health, Geriatrics
Impact of Cholinesterase Inhibitors on Driving Ability in Healthy Older Adults
The goal of the study is to assess the role of cholinesterase inhibitors in affecting the driving ability of cognitively intact seniors using driving simulators.
- Trial name
- NCT00482001
- Testing
- donepezil
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Nausea, Vomiting
Ondissolve in the Prophylaxis/Rescue of Radiation Induced Nausea and Vomiting
The primary objective of the study is to examine the efficacy of Ondissolve for the prevention/rescue of Acute and Delayed Phase radiation induced nausea and vomiting (RINV) in patients undergoing single or multiple fraction…
- Trial name
- NCT02006056
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Low Milk Supply
Enhancing Breast Milk Production With Domperidone in Mothers of Preterm Neonates
The purpose of this study is to evaluate the safety and efficacy of Domperidone in those mothers who are identified as having difficulty with breast milk production to meet the nutritional needs of their infant in the neonatal…
- Trial name
- EMPOWER (NCT01512225)
- Testing
- Domperidone maleate
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Sunnybrook Health Sciences Centre
Latent Cancer (Prostate)
Impact on Instructional Video on Patients' Compliance With Preparation During CT Planning for Prostate Cancer
Rectal toxicity limits dose escalated intensity modulated radiotherapy (IMRT) for prostate cancer. The dose volume constraints that predict for rectal toxicity require minimizing prostate motion and rectum and bladder filling of…
- Trial name
- NCT02410291
- Testing
- Educational video
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Venous Thromboembolism
Toronto Thromboprophylaxis Patient Safety Initiative
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE, is one of the common and preventable complications of hospital stay.
- Trial name
- TOPPS (NCT01869075)
- Testing
- Knowledge Translation (KT) toolkit
- Where
- Canada
- Volunteers
- 1,895 people
- Sponsor
- Sunnybrook Health Sciences Centre