Clinical trials: sponsored by Tata Memorial Centre
Seminoma
Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma
Testicular tumors account for 1% of all cancers in males and germ cell tumors comprise 95% of all testicular cancers. Seminomas consist of around 50% of cases.
- Trial name
- NCT05142982
- Testing
- Radiotherapy
- Where
- 2 sites in India
- Volunteers
- 74 people
- Sponsor
- Tata Memorial Centre
Glioma
Craniospinal Irradiation in Histone AlteRed Midline Glioma
Paediatric H3K27/H3G34 mutant diffuse midline gliomas are high grade gliomas that arise in midline structures/cerebral hemispheres and are known to have dismal outcomes.
- Trial name
- CHARM (NCT06720727)
- Testing
- craniospinal irradiation
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Tata Memorial Centre
Critically Ill Adults in the ICU, Requiring Endotracheal Intubation
Effect of a FLUid Bolus or a Low Dose VAsopressor Infusion on Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation.
Tracheal intubation, which is one of the most commonly performed procedures in the care of critically ill patients in intensive care unit, is associated with a high incidence of complications.
- Trial name
- FLUVA (NCT05318066)
- Testing
- Ringer Lactate and Norepinephrine infusion
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Colorectal Cancer, Ovarian Cancer
An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Peritoneal carcinomatosis is a common event in the natural history of colorectal and other digestive tract cancers. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides a promising…
- Conditions
- Colorectal Cancer, Ovarian Cancer, Peritoneal Disease
- Trial name
- NCT02754115
- Testing
- Hyperthermic intraperitoneal chemotherapy
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Tata Memorial Centre
Rectal Adenocarcinoma, Rectal Cancer
Asian Watch-and-Wait Database (AWWD)
The standard treatment approach of localized rectal adenocarcinoma involves neoadjuvant radiotherapy and chemotherapy followed by assessment for surgery and optional adjuvant chemotherapy.
- Trial name
- AWWD (NCT06631443)
- Where
- India
- Volunteers
- 337 people
- Sponsor
- Tata Memorial Centre
Oral Mucositis (Ulcerative)
Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04870060
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Tata Memorial Centre
Female Breast Cancer
Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serum Biomarkers and on PBMCs in Breast Cancer Surgery
Surgery, perioperative stress, anaesthetics and analgesics may modulate the immunosurveillance mechanisms and overwhelm host defences that normally maintain a balance between immunity \& carcinogenesis.
- Trial name
- NCT03005860
- Testing
- 2,6-Diisopropylphenol, Fluoromethyl hexafluoroisopropyl ether, Fentanyl Citrate
- Where
- India
- Sponsor
- Tata Memorial Centre
Oral Mucositis (Ulcerative)
Randomized Trial of Curcumin to Reduce Mucositis in Autologous Transplant Setting
Mucositis is a very common complication in bone marrow transplant setting. It is a result of injury to the gut caused by high dose chemotherapy.
- Trial name
- NCT04896164
- Testing
- Curcumin Lozenges
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Tata Memorial Centre
Gastric Cancer
"Phase III Randomized Trial Comparing D2 vs D3 Lymphadenectomy With Gastric Cancer Following Neoadjuvant Chemotherapy
Stomach cancer is the second most common cause of cancer-related deaths in India. Curative surgery offers the only chance of improving survival in this cancer.
- Trial name
- NCT02139605
- Testing
- D3 Lymphadenectomy
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Tata Memorial Centre
Septic Shock
Hemodynamic Resuscitation and Monitoring in Early Sepsis
"Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES Study)" involves recording of patient's medical data related to that has been collected as part of his/her routine medical care in ICU.
- Trial name
- HERMES (NCT04143035)
- Testing
- No Intervention
- Where
- 246 sites in India
- Volunteers
- 500 people
- Sponsor
- Tata Memorial Centre
Operable Breast Neoplasms
Correlation of Predictive Accuracy of PREDICT Version 2.2 of Indian Women With Operable Breast Cancer
This is an observational retrospective study which aims at comparing the 5-year survival estimates from "PREDICT V2.2" with observed 5-year outcome from our dataset of Indian women treated for operable breast cancer.
- Trial name
- PREDICT (NCT04985253)
- Testing
- prediction of overall survival using Web based PREDICTV2.0 portal
- Where
- India
- Volunteers
- 2,780 people
- Sponsor
- Tata Memorial Centre
Breast Cancer Patients
Role of Exercise in Breast Cancer Patient Undergoing Treatment
Randomized controlled trial to evaluate the impact of yoga on QOL is also powered to evaluate the impact of yoga on survival. Study involves various phases of yoga(divided in three phases: Phase I/II/III) during treatment and…
- Trial name
- NCT05009849
- Testing
- Yoga Exercises
- Volunteers
- 850 people
- Sponsor
- Tata Memorial Centre
Non-Invasive Bladder Urothelial Carcinoma
Intravesical BCG: is the Urinary Bladder Ready to Receive it
Prospective cohort and Prospective observational study which aims To define the healing time-frame of the resected area of the bladder after TURBT.
- Trial name
- NCT05335512
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Centre
Hemorrhagic Cystitis
Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs
To assess the efficacy of oral chlorophyllin tablets for urinary bleeding following radiation therapy for cancers of pelvic organs.
- Trial name
- CLARITY (NCT05348239)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Tata Memorial Centre
Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Surgery Vs Chemoradiation for Oropharyngeal Cancer- A Phase II/III Integrated Design Randomized Control Trial
The oropharyngeal areas mainly comprises of the tonsil, base tongue (BOT), soft palate and the posterior pharyngeal wall. Traditionally, surgical resection of oropharyngeal cancers (OPC) was a standard procedure, often performed…
- Trial name
- SCOPE (NCT05144100)
- Testing
- Surgery with or without Neck Dissection, Radiation, Cisplatin based chemotherpay
- Where
- India
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Pain
Comparison of Patient Controlled & Continuous Epidural Analgesia in Thoraco-abdominal Surgeries in Cancer Patients
This study aims to compare the efficacy of pain control, the consumption of local anesthetic and opioids, side effects, and patient satisfaction between continuous epidural infusion and patient controlled epidural analgesia after…
- Trial name
- NCT02803385
- Testing
- Continous Epidural Analgesia, Patient Controlled Epidural Analgesia
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Tata Memorial Centre
Health Personnel Attitude, Health Knowledge, Attitudes, Practice
A Survey to Assess Knowledge, Attitudes & Practices in Surgeons With Regards to Breast Conservation Surgery & Mastectomy
With increasing evidence the management of breast cancer surgery has seen a paradigm shift towards breast conservation, heralding an era of oncoplastic breast surgery.
- Trial name
- NCT04799951
- Testing
- a survey questionnaire to find knowledge, attitude and practices in treatment of breast cancer.
- Where
- India
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Breast Cancer Female, Neuropathic Pain
Prevalence of Paclitaxel Induced CIPN-Related Pain and CIPN in Indian Patients With Breast Cancer
Since its introduction in the 1970s, Paclitaxel has been used as an effective anticancer agent against lung, breast, ovarian, leukopenia and liver cancer.
- Trial name
- NCT03022162
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Tata Memorial Centre
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Pain Syndrome, Mastectomy
Postmastectomy Pain Syndrome in an Indian Cancer Hospital
Breast cancer is the most common cancer in women in India and accounts for 27% of all cancers in women. Incidence rises in early thirties, peaks at 50-64 years. Approximately 48% are below 50 years of age.
- Conditions
- Pain Syndrome, Mastectomy, Quality of Life
- Trial name
- NCT03067922
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tata Memorial Centre