Clinical trials: sponsored by Technical University of Munich
New Healthcare Approach
Primary Hormone-sensitive Breast Cancer: Need-driven Health Care Improvement by Patient-centred Digital Application
The investigators designed a prospective, 2-armed, cluster-randomized multicenter clinical trial on the effect of a by a digital application triggered intervention on quality of life and therapy-adherence among breast cancer…
- Trial name
- PRISMA (NCT05503160)
- Testing
- Intervention
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technical University of Munich
Multiple Sclerosis, Relapsing-Remitting, Optic Neuritis
Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis
The aim of this monocentric randomized controlled intervention study is to improve visual function in persons with multiple sclerosis following optic neuritis (neuritis nervi optici) by means of a light stimulation.
- Trial name
- ONSTIM (NCT06389968)
- Testing
- Light stimulation
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Health Care Survey
Anonymous Survey of Breast Cancer Patients Concerning Their Use of Medical Apps
Breast cancer patients complete questionnaires concerning their use of medical apps.
- Trial name
- Survey_App (NCT05605184)
- Testing
- Survey
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Pancreatic Duct Dilatation
Main Pancreatic Duct Diameter
The maximal diameter of the pancreatic duct will be measured by endoscopic ultrasound at four different parts: Pancreatic head Pancreatic neck Pancreatic body Pancreatic tail
- Trial name
- NCT05385354
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Technical University of Munich
Adenomatous Polyps
A Comparison of the Resection Rate for Hot and Cold Snare Polypectomy of Colorectal Polyps (10-15 Mm)
Colorectal cancer (CRC) has become the third most common malignant tumor and is the second leading cause of cancer related deaths worldwide. Adenomatous polyps of the colon are possible precursor lesions for CRC.
- Trial name
- COLDSNAP-2 (NCT04816292)
- Testing
- Active Comparator: Hot Snare Polypectomy, Experimental: Cold Snare Polypectomy
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- Technical University of Munich
Urinary Tract Infection Chronic
Individualized Homeopathy to Reduce the Use of Antibiotics in Women With Recurrent Uncomplicated Urinary Tract Infections
The aim of the study is to determine the efficacy of individualised homeopathic drug treatment (potency C200 and C1000) compared to placebo in females (age 18<65) with recurrent urinary tract infections, per definition ≥ 2 UTI in…
- Trial name
- iHOM (NCT05545514)
- Testing
- One out of 140 predefined homeopathic medical products (HMP) in potency C200 or C1000,
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Technical University of Munich
Healthy Controls
Healthy Control Population for PAIS-ME/CFS: Study to Evaluate Possible Biomarkers and Methods for Examination of PAIS-ME/CFS Diagnostics in Healthy Volunteers
Using the data from the HelP study, the underlying processes of the diseases ME/CFS and PAIS are to be researched and elucidated.
- Trial name
- HelP (NCT06653712)
- Testing
- Diagnostic Test
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Schizophrenia, Schizoaffective Disorder
Efficacy of an Early Antipsychotic Switch in Case of Poor Initial Response to the Treatment of Schizophrenia
The main aim of the trial is to study whether a change of medication in non-responders to a two-weeks antipsychotic drug trial is more effective than continued treatment with the same antipsychotic.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT01029769
- Testing
- Olanzapine or amisulpride
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- Technical University of Munich
Diabetes Mellitus, Type 1
GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)
The GPPAD-POInT Study is designed as a randomized, placebo-controlled, double blind, multicentre, multinational primary prevention phase IIb study aiming to induce immune tolerance to beta-cell autoantigens through regular…
- Trial name
- NCT03364868
- Testing
- Oral Insulin
- Where
- 7 sites in Belgium, Germany and 3 more
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Stage 1 Diabetes Mellitus, Type 1
Fr1da Insulin Intervention
Type 1 diabetes (T1D) results from an autoimmune destruction of the insulin-producing beta cells. The process of autoimmune destruction is identified by circulating islet autoantibodies to beta cell antigens, and is mediated by a…
- Trial name
- NCT02620072
- Testing
- Oral Insulin
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Experimental Pain in Healthy Human Subjects
How do Alpha Oscillations Shape the Perception of Pain? - An EEG-based Neurofeedback Study
Pain is closely linked to alpha oscillations (8 -13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing.
- Trial name
- NCT05570695
- Testing
- attention right training, ARTNF, attention left training, ALTNF
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Infections, Transplant Complication
The Transplant Cohort of the German Center for Infection Research
Medical data and biological samples obtained from transplant patients are collected and managed across Germany with the help of the DZIF Transplant Cohort.
- Conditions
- Infections, Transplant Complication, Transplant Failure, Immunosuppression
- Trial name
- NCT06346665
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- Technical University of Munich
Cerebral Palsy, Spastic, Transcranial Magnetic Stimulation, Repetitive
Priming Effects of Ultra-high Frequency Quattro Pulse Transcranial Brain Stimulation Prior to Hand Motor Function Training in Children With Unilateral Spastic Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) leads to life-long impairment with a hemiparesis of the affected side of the body. Rehabilitation efforts combine evidence based methods such as constrained induced movement therapy (CIMT)…
- Trial name
- TRAINCP (NCT05165472)
- Testing
- Quadri-pulse theta burst stimulation
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Technical University of Munich
NSCLC Stage IIIA/B
Targeted Natural Killer (NK) Cell Based Adoptive Immunotherapy for the Treatment of Patients With Non-Small Cell Lung Cancer (NSCLC) After Radiochemotherapy (RCT)
Targeted Natural Killer (NK) cell based adoptive immunotherapy for the treatment of patients with Non-Small Cell Lung Cancer (NSCLC) after radiochemotherapy (RCT)
- Trial name
- NCT02118415
- Testing
- Hsp70-peptide TKD/IL-2 activated, autologous NK cells
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- Technical University of Munich
Hereditary Breast and Ovarian Cancer
Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers
BRCA1/2 mutation carriers have a considerably increased risk to develop breast and ovarian cancer during their lifetime. There is evidence from the literature that for sporadic breast cancer disease risk and the course of disease…
- Trial name
- LIBRE (NCT02087592)
- Testing
- Structured exercise training plus mediterranean diet
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Technical University of Munich
Hereditary Breast and Ovarian Cancer
Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers
The hypothesis of this 3 year, prospective randomized multicenter efficacy trial is that a structured life-style intervention program with exercise training and mediterranean diet is effective regarding increased adherence to a…
- Trial name
- LIBRE-2 (NCT02516540)
- Testing
- Structured exercise training plus mediterranean diet
- Where
- 19 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Technical University of Munich
Perioperative/Postoperative Complications, Outcome
Evaluation of BIomarkers for POstoperative Complications in Non-cardiac Surgery Patients
Aim of this study is to evaluate whether the periopertive course is able to predict postoperative complications. Several approaches will be choosed to optimize perioperative risk stratification predicting postoperative…
- Trial name
- NCT03765372
- Where
- Germany
- Volunteers
- 1,598 people
- Sponsor
- Technical University of Munich
Post-COVID Condition
Munich Long COVID Registry for Children, Adolescents, and Adults
The MLC-R aims to create a large-scale registry that provides data on epidemiology, phenotypes, and disease trajectories of and health care for Long COVID at any age in Germany, which can be used for future clinical trials.
- Trial name
- MLC-R (NCT05638724)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Exercise
The Munich Cardiovascular Adaptation in Young Athletes Plus Study
The aim of the 3-year longitudinal study is to investigate the cardiovascular system's response to training loads in young athletes.
- Trial name
- MuCAYAplus (NCT06259617)
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Postoperative Delirium
Prevention of Postoperative Delirium in Elderly Patients
Prevention of Postoperative Delirium in the care of Elderly Patients. A Monocentric, Prospective Intervention Study With the Question of Whether the Incidence, Length and Severity of Postoperative Delirium Can be Reduced by…
- Trial name
- PODproject (NCT06248684)
- Testing
- standardized prevention and therapy measures
- Volunteers
- 15,000 people
- Sponsor
- Technical University of Munich