Clinical trials: sponsored by Technical University of Munich
Infectious Mononucleosis, Epstein-Barr Virus Infections
Study on Infectious Mononucleosis in Munich
This observational clinical study aims at the identification of novel biomarkers and causative factors of complicated and/or protracted Epstein-Barr virus-associated infectious mononucleosis (IM).
- Trial name
- IMMUC (NCT06002802)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Post-operative Delirium
Neuroimaging Risk of Postoperative Delirium
Postoperative delirium (POD) is a frequent disorder of consciousness, arousal and attention in elderly patients following surgery. The glymphatic system is a newly discovered waste cleaning system of the brain.
- Trial name
- NCT06236854
- Testing
- Delirium assessment (observational, not interventional)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Heart Failure, Diastolic
Exercise Training in Heart Failure With Preserved Ejection Fraction - a Long-term Follow-up
Exercise training is an effective therapy for patients with heart failure with preserved ejection fraction. However, it is unclear, whether a one-year intervention has a sustainable effect beyond the active study phase.
- Trial name
- NCT05162859
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Technical University of Munich
Preoperative Anxiety, Perioperative Complication
Binaural Beat Stimulation to Improve Patient Outcome After Surgery and Anesthesia
We plan to evaluate the potential of binaural beat stimulation as a cost-effective tool to improve perioperative patient outcome.
- Trial name
- NCT05533112
- Testing
- Binaural Beat Stimulation
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Technical University of Munich
Anesthesia
EEG-fMRI Experiments During Anesthesia Induction With Propofol
This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol.
- Trial name
- NCT06179719
- Testing
- Propofol, visual flickering stimulation at the alpha frequency
- Where
- 2 sites in Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Lifestyle, Weight Gain
Healthy Living in Pregnancy
Multicenter and multidisciplinary public health project in 10 regions of Bavaria, a federal state of Germany, targeting maternal and fetal health.
- Conditions
- Lifestyle, Weight Gain, Pregnancy
- Trial name
- GeliS (NCT01958307)
- Testing
- Lifestyle intervention
- Where
- 5 sites in Germany
- Volunteers
- 2,286 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Schistosomiasis in Children, Social Acceptance
Adoption of L-PZQ for Schistosomiasis by Endemic Counties - Social Science Research Study
Knowledge, acceptability and perception of paediatric schistosomiasis and its treatment will be explored through a social science-driven mixed-methods approach within three endemic countries: Kenya, Uganda and Côte d'Ivoire.
- Trial name
- ADOPT (NCT05350462)
- Testing
- Community pilot L-PZQ distribution - intervention is NOT part of this observational study
- Where
- 3 sites in Côte d’Ivoire, Kenya and 1 more
- Volunteers
- 225 people
- Sponsor
- Technical University of Munich
Obesity, Cardiovascular Risk
Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence
The purpose of the study is to determine the genetic influence on short-, middle- and longterm effects of an inpatient lifestyle therapy program in overweight and obese children and adolescents.
- Trial name
- LOGIC (NCT01067157)
- Testing
- LOGIC
- Where
- Germany
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Impaired Synaptic Plasticity, Impaired Cognition
Synaptic Plasticity and Cognitive Function in RASopathies
The project is targeting cognitive impairment, one of the main health problems of patients with RAS pathway disorders. The aim of this study is to translate findings of animal studies to humans.
- Trial name
- SynCoRAS (NCT03504501)
- Testing
- Lovastatin, Lamotrigine
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Technical University of Munich
Neurocysticercosis, Taeniosis
Investigation of Environmental Factors Associated With Transmission of T. Solium in Endemic Villages of Zambia
This study aims to determine the prevalence of taeniosis and (neuro)cysticercosis in two districts in the southern (Gwembe) and eastern province (Chipata) of Zambia.
- Trial name
- TEPIM (NCT03874689)
- Where
- Zambia
- Volunteers
- 2,921 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Helicobacter Pylori Infection, Helicobacter Pylori Gastritis
Helicobacter Pylori Local Prevalence and Antibiotic Resistance
The clinical management of H. pylori infection depends essentially on two factors, prevalence and local resistance. In Germany, only limited data from rather small cohorts currently exist regarding both factors.
- Conditions
- Helicobacter Pylori Infection, Helicobacter Pylori Gastritis, Drug Resistant Bacterial Infection, Antibiotic Resistant Infection
- Trial name
- HelicoPTER (NCT05561504)
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Neurocysticercosis
Treatment of Patients With Active Neurocysticercosis in Eastern Africa
This multi-centre prospective cohort study of symptomatic patients with active neurocysticercosis (NCC) aims to identify factors related to treatment success of anthelmintic therapy.
- Trial name
- TOPANA (NCT03834337)
- Where
- Tanzania
- Volunteers
- 63 people
- Sponsor
- Technical University of Munich
HIV-Infection
Dual Therapy With Boosted Darunavir + Dolutegravir
A switch strategy to investigate whether a dual therapy with Ritonavir-boosted (RTV) Darunavir (DRV) + Dolutegravir (DTG) over 48 weeks is non-inferior to a continuous standard of care therapy with RTV-boosted DRV in combination…
- Trial name
- Dualis (NCT02486133)
- Testing
- Prezista, Norvir, Tivicay
- Where
- Germany
- Volunteers
- 269 people
- Sponsor
- Technical University of Munich
Neurocysticercosis, HIV/AIDS
The Burden of (Neuro)Cysticercosis Among People Living With HIV in Rural Tanzania
This study aims to compare the burden of neurocysticercosis among people living with HIV to people not infected with HIV.
- Trial name
- CYSTINET_Tz (NCT03851419)
- Testing
- Diagnosis of (Neuro)cysticercosis
- Where
- Tanzania
- Volunteers
- 2,584 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Adenocarcinoma of the Esophagogastric Junction
Evaluation for the Individualization of Therapy in Adenocarcinomas of the Gastroesophageal Junction
Metabolic and Molecular Response evaluation for the individualization of therapy in adenocarcinomas of the gastroesophageal junction by evaluation of the R0 resection rate for patients with metabolically (ie, according to PET…
- Trial name
- MEMORI (NCT02287129)
- Testing
- Oxaliplatin, Epirubicin, Capecitabine
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea
Effect of Upper Airway Stimulation in Patients With Obstructive Sleep Apnea
Upper Airway Stimulation is a new therapy, which is available for patients with obstructive sleep apnea, who are non-compliant to the standard treatment continuous positive airway pressure (CPAP) therapy.
- Trial name
- EFFECT (NCT03760328)
- Testing
- Upper Airway Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Acute ACE-induced Angioedema
Randomized, Double-blind, Two Arms, Multicenter, Phase III Study of Berinert for Treatment of ACE Induced Angioedema
This trial is a randomized, double-blind, two arms, multicenter, Phase III study of Berinert for treatment of ACE induced Angioedema.
- Trial name
- NCT01843530
- Testing
- Berinert, Clemastin, Cortisone acetate
- Where
- 4 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Technical University of Munich
Hematologic Malignancies
Register of Blood Stem Cell Transplantation
Register of patients with blood stem cell transplantations (autologous, allogen).
- Trial name
- REBB3M (NCT04263857)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Technical University of Munich
Perioperative/Postoperative Complications
Perioperative Risk Calculator
The aim of this project is to develop a machine-learning model for calculating the risk of postoperative complications. In addition to the data collected during the premedication, the model will include all intraoperative values…
- Trial name
- PROTECT (NCT04092933)
- Volunteers
- 175,559 people
- Sponsor
- Technical University of Munich
Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS
Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC).
- Conditions
- Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- POTS-CFS (NCT06054958)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich