Clinical trials: sponsored by Technical University of Munich
Critical Illness, Self-Assessment
Comparison of Self-assessment vs. Assessment by Others of Critically Ill Patients
We will test the results of standardized questionnaires for patients admitted to intensive care assessed by relatives/caregivers compared to the patient itself.
- Conditions
- Critical Illness, Self-Assessment, Assessment, Self
- Trial name
- ASTON (NCT03785444)
- Testing
- WHODAS 2.0, EQ5D, IADL
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Metabolomics, Critical Care
Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma
In this mono-center pilot trial, polytrauma patients admitted to intensive care will be included. Investigators are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular…
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE II (NCT03819959)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Technical University of Munich
Colorectal Neoplasms
European Serrated Adenoma Classification Score
The aim of the study is to develop a score system in order to differentiate adenomatous polyps, hyperplastic polyps and serrated adenomas on the basis of optical features.
- Trial name
- ESCO (NCT03486418)
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Technical University of Munich
Colorectal Polyp, Colorectal Adenoma
Efficacy and Safety of Cold Snare Polypectomy (CSP) of Intermediate Sized Colorectal Polyps 10-15 mm
Colorectal cancer (CRC) has become the third most common malignant tumor and is the second leading cause of cancer related deaths worldwide. Adenomatous polyps of the colon are possible precursor lesions for CRC.
- Trial name
- COLDSNAP-1 (NCT04464837)
- Testing
- Cold Snare Polypectomy of intermediate sized polyps (10-15 mm)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Technical University of Munich
Experimental Pain in Healthy Human Subjects
Modulating Pain Using Transcranial Alternating Stimulation (tACS) in Healthy Human Subjects
Pain is a highly complex and subjective phenomenon which results from the dynamic integration of sensory and contextual (i.e. cognitive, emotional, and motivational) processes.
- Trial name
- NCT03805854
- Testing
- 10 Hz tACS of the bilateral somatosensory cortex, 10 Hz tACS of the prefrontal cortex, 80 Hz tACS of the bilateral somatosensory cortex
- Where
- Germany
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Ankle Fractures
Outcome Following Semitubular Plate vs. Polyaxial Locking Plates
In this prospective study, all patients with distal fibula fractures (AO 44 B1.1, B1.2, B1.3), with indication for surgery were included.
- Trial name
- NCT04370561
- Testing
- ORIF non-locking, ORIF locking
- Volunteers
- 45 people
- Sponsor
- Technical University of Munich
COVID
Establishing a COVID-19 Prospective Cohort for Identification of Secondary HLH
SARS-CoV2 has become a pandemic disease putting an enormous burden on health care systems around the world. A considerable amount of patients require intensive care treatment for Covid-19 associated pneumonia.
- Trial name
- COVIDHLH (NCT04347460)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Clavicle Fracture
Benefit of Surgical Hardware Removal Following Clavicle Fracture
Little is known about the beneficial aspects of elective implant removal following plate osteosynthesis of displaced clavicle fractures.
- Trial name
- NCT04343118
- Testing
- Hardware Removal
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Radiofrequency Resection
Feasibility of Radiofrequency Resection in Oropharyngeal Tumor Surgery
In the last years radiofrequency resection has become a frequent method in surgical subspecialties. Although many departments are using this method for the resection of Tumor in the oropharynx, there is no study so far which…
- Trial name
- NCT03175770
- Testing
- transoral radiofrequency Resection in Oropharyngeal Tumor Surgery
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Technical University of Munich
Obstructive Sleep Apnea
Upper Airway Stimulation Versus Continuous Positive Airway Pressure
Standard therapy in patients with obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP). 30% to 50% are not adherent to this therapy and need an alternative treatment.
- Trial name
- NCT03756805
- Testing
- upper airway stimulation, continuous positive airway pressure
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Technical University of Munich
Degeneration Spine
Primary Sacroiliac Fusion Versus Fusion to the Sacrum for Degenerative Disease of the Lumbar Spine
To prove that the use of additional S2alar-iliac screws for pure lumbar fusions due to degenerative lumbar disease provides superior outcome compared to the standard procedure of fusion to S1.
- Trial name
- PSEUDOLUSE (NCT04308018)
- Testing
- S2alar-iliac screws, S1 screws
- Volunteers
- 148 people
- Sponsor
- Technical University of Munich
Glioblastoma
Adjuvant Stereotactic Fractionated Radiotherapy to the Resection Cavity in Recurrent Glioblastoma
This multi-center randomized controlled phase II trial will investigate the impact of stereotactic fractionated radiotherapy to the resection cavity of complete resected recurrent glioblastoma on progression free survival.
- Trial name
- GlioCave/NOA17 (NCT02715297)
- Testing
- SRT to the resection cavity
- Where
- Germany
- Volunteers
- 162 people
- Sponsor
- Technical University of Munich
Cardiopulmonary Resuscitation
Pilot Study Comparing Ventilation Modes During CPR With Mechanical Compression Device.
Comparison of three ventilation modes (volume controlled, BIPAP and CPAP) during cardiopulmonary re-suscitation with a mechanical compression device in the emergency room.
- Trial name
- COVME (NCT03347175)
- Testing
- Volume controlled ventilation, Pressure controlled ventilation, CPAP mode
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Renal Transplant Surgery
Goal Directed Hemodynamic Management and Renal Outcome After Renal Transplant Surgery
This study is designed to compare the incidence of delayed graft function in patients following renal transplant surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group (using…
- Trial name
- IROR (NCT01485432)
- Testing
- PiCCO® Monitoring
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Technical University of Munich
Delirium
Prediction of PACU Delirium Using EEG - German Validation Study
Aim of this observational study is to investigate whether frontal electroencephalogram analysis is able to predict increased risk for PACU delirium.
- Trial name
- PACUD-EEG (NCT03287401)
- Testing
- Electroencephalography
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Gastric Cancer, Breast Cancer
HER2-Peptide Vaccination of Patients With Solid Tumors
Investigation of peptide vaccination targeting HER2/neu in patients with metastasized breast or gastric cancer with moderate HER2/neu expression.
- Trial name
- HER2 (NCT02276300)
- Testing
- Cyclophosphamide, Sargramostim, HER2-Peptid-Vakzine
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Technical University of Munich
Psoriasis
BOSTRIP: Biomarkers of Systemic Treatment Response in Psoriasis
Metabolomics of systemic psoriasis treatment
- Trial name
- Bostrip (NCT01403012)
- Testing
- Withdrawal of venous blood samples
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Technical University of Munich
Early Onset Alzheimer Disease, Frontotemporal Dementia
RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia
The RHAPSODY-plus project consists of two parts. In a first step carers of people with young onset dementia (YOD; onset before the age of 65) have the opportunity to use the RHAPSODY online program (Kurz et al., 2016) to inform…
- Trial name
- RHAPSODY-plus (NCT03923517)
- Testing
- RHAPSODY online program and MEET online sessions
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Exercise Training, Coronary Artery Disease
Sport as Therapy: a 6-months Lifestyle-Intervention for Patients With Coronary Artery Disease and/or Diabetes
Regular exercise training has shown to improve exercise capacity in patients with cardiovascular disease. The feasibility and transferability of exercise training in a community based cardiovascular rehabilitation setting is…
- Conditions
- Exercise Training, Coronary Artery Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT03208751
- Testing
- Exercise training
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Pancreas Cancer
Evaluation and Comparison of the Growth Rate of Pancreatic Cancer Patient-derived Organoids
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer. Despite advances in the understanding of the mechanisms underlying PDAC pathogenesis, the impact on patient benefit is lagging.
- Trial name
- NCT03990675
- Testing
- FNA, FNB
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich