Clinical trials: sponsored by The Hospital for Sick Children
Machine Learning, Cardiovascular Outcome
PACT Involvement in Cardiology Patients
The goal of this trial is to determine the effectiveness of a machine-learning (ML) model predicting a serious cardiac event within the next three months, when compared pre- versus post-deployment, in pediatric cardiac…
- Conditions
- Machine Learning, Cardiovascular Outcome, Pediatric Palliative Care, Pediatric Cardiology
- Trial name
- NCT06886529
- Testing
- ML-based intervention
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- The Hospital for Sick Children
Machine Learning, Prediction Models
Timely Ordering of Pharmacogenetic Testing
The goal of this trial is to learn if a machine learning (ML) model can help optimize drug therapy in the pediatric population. The main question[s] it aims to answer are whether a machine learning model predicting receipt of a…
- Conditions
- Machine Learning, Prediction Models, Pediatrics, Precision Medicine
- Trial name
- NCT06902688
- Testing
- ML-based intervention
- Where
- Canada
- Volunteers
- 275 people
- Sponsor
- The Hospital for Sick Children
Evaluation of Mainstreamed Models of Genetic Service Delivery, Genetic Disease
Implementation-effectiveness Trial of Mainstreaming of Clinical Genomic Sequencing for Rare Disease in Ontario, Canada
Genomic sequencing (GS) is increasingly recommended as a diagnostic test for patients with suspected genetic disorders, but access often remains limited to those referred to medical geneticists.
- Conditions
- Evaluation of Mainstreamed Models of Genetic Service Delivery, Genetic Disease, Neurodevelomental Disorders
- Trial name
- NCT07799792
- Testing
- Genome-wide Sequencing Ordering
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Mechanical Ventilation, Paediatric Intensive Care
Effort of Breathing and Dyssynchrony Burden During Assisted Ventilation in Paediatric Patients
The goal of this trial is to learn if one mode of mechanical ventilation (i.e. machine to help with breathing) is better than another in children who need help from a machine to breathe.
- Conditions
- Mechanical Ventilation, Paediatric Intensive Care, Paediatric Dysfunctional Breathing
- Trial name
- WOB (NCT07796321)
- Testing
- Pressure Control Mode, Pressure Support Mode
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- The Hospital for Sick Children
Rheumatic Diseases, Arthritis
Pain-Sleep in Rheumatic Disease
Overall, our understanding of how pain and sleep are experienced and how they can be treated in teenagers with rheumatic diseases is limited.
- Conditions
- Rheumatic Diseases, Arthritis, Lupus, Lupus Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07775612
- Testing
- Better Nights, Better Days for Youth
- Volunteers
- 43 people
- Sponsor
- The Hospital for Sick Children
Children and Youth With Medical Complexity
Promoting Intensive Transitions for Children and Youth With Medical Complexity From Pediatric to Adult Care
Medical advances have allowed many more children and youth with medical complexity (CMC) to survive well into adulthood. However, this has not been matched with increases in knowledge of complex conditions or the availability of…
- Trial name
- PITCare (NCT06093386)
- Testing
- Intensive Transition Support
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- The Hospital for Sick Children
Pediatric Urolithiasis, Ureteral Stent-Related Symptoms
Comparison of Ureteral Stent Designs in Children With Kidney Stones
This study will compare two commonly used ureteral stents in children and adolescents undergoing staged treatment for kidney stones.
- Trial name
- NCT07742358
- Testing
- Polaris Ultra Ureteral Stent, Cook Double-J Ureteral Stent
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Arthritis, Juvenile, Arthritis, Childhood
Feasibility of a Diet Intervention for Juvenile Arthritis
Families of children with arthritis are highly interested in the benefits of diet to improve their child's disease and future health outcomes.
- Conditions
- Arthritis, Juvenile, Arthritis, Childhood, Juvenile Idiopathic Arthritis
- Trial name
- DIGEST-JA (NCT06474546)
- Testing
- Diet intervention
- Where
- 7 sites in Canada
- Volunteers
- 54 people
- Sponsor
- The Hospital for Sick Children
Intubation Performance Using AI Versus Conventional Videolaryngoscope in a Mannikin
AI-assisted Endotracheal Intubation
This study evaluates artificial intelligence (AI)-assisted videolaryngoscopy for endotracheal intubation in a simulated pediatric airway environment.
- Trial name
- NCT07508826
- Testing
- AI-assisted videolaryngoscopy, Conventional Intubation
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Neonatal Mortality, Omphalitis
Newborn Care Kit to Save Lives in GB, Pakistan
Neonatal deaths account for almost half of all deaths in children under 5 years of age. Pakistan has the world's highest neonatal mortality rate (NMR), and many of these deaths are preventable.
- Conditions
- Neonatal Mortality, Omphalitis, Post-Partum Hemorrhage
- Trial name
- iNCK (NCT04798833)
- Testing
- Integrated Newborn Care Kit (iNCK)
- Where
- 2 sites in Pakistan
- Volunteers
- 19,344 people
- Sponsor
- The Hospital for Sick Children
Pediatric Heart Failure, Congenital Heart Disease (CHD)
MedlyPeds Feasibility Study
SickKids and UHN have developed MedlyPeds which is a smart phone application designed to remotely monitor patients with heart disease.
- Conditions
- Pediatric Heart Failure, Congenital Heart Disease (CHD), Acquired Heart Disease, Pulmonary Hypertension
- Trial name
- NCT07556185
- Testing
- MedlyPeds App
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Intestinal Failure, Parenteral Nutrition
Weaning is Winning? (WeWin Study)
We propose a multicenter prospective study on pediatric patients with intestinal failure (IF) who weaned off parenteral nutrition (PN).
- Trial name
- NCT06525753
- Testing
- Weaning off Parenteral Nutrition
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- The Hospital for Sick Children
Malnutrition, Child, Nutrition Poor
Implementation of P-INPAC
The framework for Pediatric Integrated Nutrition Pathway for Acute Care (P-INPAC) was developed by the Canadian Malnutrition Task Force (CMTF); however, it has not been implemented in a research setting.
- Trial name
- P-INPAC (NCT06645639)
- Testing
- Pediatric Integrated Nutrition Pathway for Acute Care Pathway (P-INPAC)
- Where
- 3 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Very Low Birth Weight Infant
Individualized Fortification of Human Milk for Infants Born ≤ 1250 g (MaxiMoM-InForM)
Very low birth weight infants have increased nutritional needs. Extra nutrients are added to their human milk feeds to help improve their nutritional status, growth and neurodevelopment.
- Trial name
- NCT05308134
- Testing
- Standard fortification, Target fortification, BUN adjustable fortification
- Where
- 20 sites in Canada
- Volunteers
- 615 people
- Sponsor
- The Hospital for Sick Children
Severe Acute Malnutrition
Evaluating RISQ System Implementation in Acutely Malnourished Children in Chad (CRIMSON)
The purpose of this study is to evaluate the effect of the Responses to Illness Severity Quantification (RISQ) system implementation on mortality and processes of care in a nutritional program treating children 6 to 59 months of…
- Trial name
- CRIMSON (NCT06123390)
- Testing
- The Responses to Illness Severity Quantification (RISQ) System
- Where
- Chad
- Volunteers
- 14,671 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea (OSA)
CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior…
- Trial name
- CHOSA (NCT07600333)
- Testing
- High Flow Nasal Cannula, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 258 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea
Dexamethasone Treatment for OSA in Children
This is a double-blinded clinical trial of children diagnosed with moderate to severe obstructive sleep apnea (OSA) on a baseline polysomnogram (PSG).
- Trial name
- NCT05638087
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea (Moderate to Severe), Obstructive Sleep Apnea
A Mindfulness-Based Intervention to Improve CPAP
The main purpose of this study is to assess the effectiveness of a mindfulness-based intervention in improving CPAP use compared to online peer support
- Trial name
- NCT05499286
- Testing
- Mindfulness Program
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Hydronephrosis, Hydronephrosis Congenital
Integrating an AI-Driven Hydronephrosis Decision-Making Tool
Hydronephrosis is a common congenital kidney anomaly. While most cases resolve on their own, some require surgery. Clinicians rely on repeated ultrasounds and sometimes invasive tests to decide if surgery is needed, but…
- Trial name
- NCT07581223
- Testing
- Machine learning model
- Volunteers
- 322 people
- Sponsor
- The Hospital for Sick Children
Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change
REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE)
This is a pilot feasibility study for a proposed full-scale randomized controlled trial to evaluate the effectiveness and safety of a reduced-dose oral prednisone (steroids) regimen to treat childhood steroid-sensitive nephrotic…
- Conditions
- Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change, Nephrotic Syndrome, Nephrotic Syndrome，Idiopathic
- Trial name
- RESPONSE (NCT06635720)
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- The Hospital for Sick Children