Clinical trials: sponsored by The Methodist Hospital Research Institute
Cutaneous Melanoma
Neoadjuvant Atezolizumab in Cutaneous Melanoma
The purpose of this research study is to see whether using atezolizumab before surgery is safe and does not cause side effects that delay surgery in participants with cutaneous melanoma that has not spread to other areas of the…
- Trial name
- NCT04020809
- Testing
- Atezolizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Dementia, Vascular, Stroke Sequelae
Home Tele Rehabilitation Therapy for Vascular Dementia
To determine whether the home telerehabilitation therapy is feasible and lessens caregiver burden in chronic stroke patients with and without vascular dementia (VaD)
- Trial name
- NCT06289569
- Testing
- Home telerehabilitation therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The Methodist Hospital Research Institute
Stroke
Non-invasive VNS in Stroke Recovery
To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery
- Trial name
- NOVUS (NCT06761404)
- Testing
- taVNS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
ER-Positive Breast Cancer, HER2-negative Breast Cancer
Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer
The study will investigate if CDK4/6 inhibitor holiday will reset the cell cycle process to respond to the combination of fulvestrant and abemaciclib, and this approach may represent an effective therapeutic strategy to manage…
- Trial name
- NCT05305924
- Testing
- Fulvestrant Run-In
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Methodist Hospital Research Institute
Triple Negative Breast Cancer, Anthracycline-refractory TNBC
Docetaxel Chemotherapy and Pembrolizumab Plus Interleukin-12 Gene Therapy in Triple Negative Breast Cancer
The purpose of this research study is to test the safety and effectiveness of docetaxel chemotherapy and pembrolizumab plus adenoviral-mediated interleukin-12 (ADV/IL-12) gene therapy in patients with anthracycline-refractory…
- Trial name
- INTEGRAL (NCT04095689)
- Testing
- Docetaxel, Pembrolizumab, IL-12 gene therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- The Methodist Hospital Research Institute
Cancer
Spiritual Care or Psychotherapy Versus Palliative Care Alone in Patients With Non-Curative Malignancies
This phase III clinical trial will evaluate the impact on survival of adding chaplain-provided spiritual care or psychotherapy/meditation to standard-of-care (SOC) and palliative measures, plus chemotherapy if recommended, and…
- Trial name
- SPC (NCT07290491)
- Testing
- Chaplain-Provided Spiritual Care, Psychotherapy and Meditation Intervention
- Where
- United States
- Volunteers
- 854 people
- Sponsor
- The Methodist Hospital Research Institute
Rabies, Rabies Human
Survey of Human Rabies Immune Globulin Safety in Children
This observational study will be conducted across the Houston Methodist system, including all hospital-based and freestanding emergency departments (ED), and up to 4 additional sites in the United States.
- Conditions
- Rabies, Rabies Human, Rabies Virus Infection, Pediatrics
- Trial name
- NCT05382650
- Testing
- Human rabies immune globulin 300 IU/mL
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- The Methodist Hospital Research Institute
Rejection Chronic Renal
Belumosudil for Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of belumosudil (brand name- REZUROCK®) on the background of standard immunosuppression will prevent…
- Trial name
- NCT06751602
- Testing
- Belumosudil 200 mg QD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Urothelial Carcinoma Bladder
Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer
This is a prospective, single-institution, single-arm, phase II clinical trial that tests a novel strategy of neoadjuvant Sasanlimab, an immune checkpoint inhibitor (ICI), in combination with stereotactic body radiation therapy…
- Trial name
- RAD-VACCINE (NCT05241340)
- Testing
- Sasanlimab, Stereotactic Body Radiation Therapy, Radical Cystectomy + pelvic lymph node dissection + urinary diversion
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Methodist Hospital Research Institute
Delirium
VoiceLove Digital Therapy for Delirium in the ICU
The study is a single-center, single-arm, prospective trial to evaluate the feasibility, safety, and acceptability of VoiceLOVE digital therapy for the management of delirium in surgical ICU patients.
- Trial name
- NCT07218484
- Testing
- VoiceLove therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Methodist Hospital Research Institute
Anterior Knee Pain Syndrome
Knee Isometric Program (KIP) Home Exercise Programs (HEP) Physical Therapy (PT) Study
The purpose of this study is to evaluate the efficacy of a knee isometric program (KIP) as compared to the current gold standard treatment for anterior knee pain (Patellofemoral Clinical Practice Guideline [CPG] - Academy of…
- Trial name
- NCT06536426
- Testing
- Knee Isometric Program (KIP)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The Methodist Hospital Research Institute
Shoulder Injuries
IO Vancomycin in TSA
The purpose of this study is to compare two different antibiotic regimens and techniques during total shoulder arthroplasty. Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic…
- Trial name
- NCT05831774
- Testing
- Intervention - Intraosseous (IO) administration of vancomycin, Control - Standard IV administration of vancomycin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Methodist Hospital Research Institute
Surgery, Delirium
Feasibility and Acceptability of ReCognitionVR-based Cognitive Stimulation in Surgical Patients
This study aims to assess the feasibility, acceptability, and safety of using ReCognitionVR virtual reality-based software in older surgical patients.
- Conditions
- Surgery, Delirium, Delirium, Post-Operative
- Trial name
- NCT06232317
- Testing
- Virtual Reality Software, Traditional Orientation Methods
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Ventricular Tachycardia, Atrial Fibrillation
Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation
The broad, long-term objective of this project is to evaluate the therapeutic value of vein of Marshall (VOM) ethanol infusion when added to catheter ablation of atrial fibrillation (AF).
- Trial name
- VOM-R01 (NCT01898221)
- Testing
- Ethanol, Ablation
- Where
- 12 sites in United States
- Volunteers
- 343 people
- Sponsor
- The Methodist Hospital Research Institute
Multiple Sclerosis, Lower Urinary Tract Symptoms
Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder
The purpose of this research study is to evaluate higher neural changes following intra-detrusor injection of Onabotulinumtoxin-A (BTX-A) in patients with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Detrusor, Overactive
- Trial name
- NCT03033355
- Testing
- Intra-detrusor injection of Onabotulinumtoxin-A
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Carotid Endarterectomy (CEA) Surgical Patients
Ultrasound Evaluation for Baxter VASCU-GUARD Vascular Patches Post-Endarterectomy and Complications Assessment
VASCU-GUARD vascular patches with the new packaging have been available at the Houston Methodist Hospital since January 2023. This study is a retrospective chart review, aiming to compare the performance of Baxter VASCU-GUARD…
- Trial name
- VASCU-GUARD (NCT07048067)
- Testing
- Carotid endarterectomy (CEA)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Methodist Hospital Research Institute
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Total Knee Arthroplasty
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at…
- Trial name
- NCT06640491
- Testing
- IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Neurogenic Bladder, Lower Urinary Tract Symptoms
Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction
The purpose of this study is to evaluate and standardize the way providers perform OnabotulinumtoxinA (BTX-A) injections into the bladder for the diagnosis of neurogenic lower urinary tract dysfunction (NLUTD)/overactive bladder…
- Conditions
- Neurogenic Bladder, Lower Urinary Tract Symptoms, Overactive Bladder, Neuro: Neurogenic Bladder
- Trial name
- BOND (NCT06059066)
- Testing
- Standard number of injection sites, Reduced number of injection sites
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- The Methodist Hospital Research Institute
Diverticulitis, Surgical Site Infection
Surgical Site Infection Outcomes in Natural Orifice Intracorporeal Anastomosis and Extraction (NICE) Procedure - The NICE Trial
The goal of this observational study is to learn if a new surgical technique, called the NICE procedure, is as safe as standard methods for treating benign left-sided colon and rectal diseases in adults.
- Conditions
- Diverticulitis, Surgical Site Infection, Surgical Site Infections, Colorectal Surgery
- Trial name
- NCT06957236
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Methodist Hospital Research Institute