Clinical trials: sponsored by The Netherlands Cancer Institute
Anxiety
Peri-operative Slow-paced Breathing to Reduce Anxiety in Breast Cancer Surgery Patients
The purpose of this single-center trial is to examine the effects of a slow-breathing technique performed at induction of anesthesia in patients undergoing surgery for breast cancer on anxiety, scored by Spielberger's State-Trait…
- Trial name
- SlowPACE (NCT06192225)
- Testing
- pre-trained guided slow paced breathing (~6 breaths per minute)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- The Netherlands Cancer Institute
Angiosarcoma
Propranolol in Angiosarcoma
This is a window opportunity study of propranolol in patients with angiosarcoma. The aim of this study is to prospectively evaluate the activity of propranolol in the clinical setting as monotherapy, where the neoadjuvant setting…
- Trial name
- NCT04518124
- Testing
- Propranolol
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- The Netherlands Cancer Institute
Liver Metastases, Breast Cancer
Radioembolisation and Chemotherapy in Liver Metastatic Breast Cancer Patients
The goal of this multicentre clinical pilot study is to investigate the feasibility of the addition of Ho-166 radioembolization to chemotherapy in patients with liver metastastic breast cancer.
- Trial name
- HoLiBreast (NCT06142344)
- Testing
- Quiremspheres™
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 13 people
- Sponsor
- The Netherlands Cancer Institute
Malignant Melanoma Stage III
Optimal Neo-adjuvant Combination Scheme of Ipilimumab and Nivolumab
This is an open-label three-arm phase 2 trial (including a Simon stage 2 design) consisting of 90 stage III melanoma patients randomized 1:1:1 to receive either 2 courses 3 mg/kg ipilimumab + 1 mg/kg nivolumab every 3 weeks (Arm…
- Trial name
- OpACIN-neo (NCT02977052)
- Testing
- Ipilimumab, Nivolumab, Surgery
- Where
- 4 sites in Australia, Austria and 2 more
- Volunteers
- 186 people
- Sponsor
- The Netherlands Cancer Institute
Laryngeal Cancer Stage II, Laryngeal Cancer Stage III
Olaparib and Radiotherapy in Head and Neck Cancer
Accelerated, normofractionated radiotherapy is the treatment of choice in stage II-III laryngeal and oropharyngeal squamous cell carcinoma (SCC).
- Conditions
- Laryngeal Cancer Stage II, Laryngeal Cancer Stage III, Carcinoma, Squamous Cell, Head and Neck Neoplasms
- Trial name
- NCT02229656
- Testing
- radiotherapy, Olaparib
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Immunotherapy, Head and Neck Neoplasms
ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma
This is a phase IB/II trial to examine feasibility and safety of checkpoint blockade (aPD1 with or without aCTLA4) neoadjuvant to standard of care (SOC) in advanced stage head and neck squamous cell carcinoma (HNSCC), a patient…
- Trial name
- IMCISION (NCT03003637)
- Testing
- Nivolumab, Ipilimumab
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- The Netherlands Cancer Institute
Lung Cancer, Surgery
Cetuxibab to Reduce Circulating Tumor Cells in Early Stage NSCLC
Cetuximab to reduce the amound of circulating tumor cells in early stage NSCLC
- Conditions
- Lung Cancer, Surgery, Circulating Tumor Cell
- Trial name
- NCT04648189
- Testing
- Cetuximab
- Where
- 2 sites in Netherlands
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer
Image-guided Navigation During Robotic Sentinel Node Removal
Image-guided navigation based on pre-operative imaging can give the surgeon more insight into the location of the sentinel nodes in relation to other anatomical structures.
- Trial name
- N21LND (NCT06091072)
- Testing
- Image-guided navigation
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- The Netherlands Cancer Institute
Carcinoma, Non-Small-Cell Lung
Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer
This is a single arm open-label multi-center phase II study, investigating disease control rate after 18 weeks of treatment with afatinib/cetuximab combination therapy in patients with advanced non-small cell lung cancer (NSCLC)…
- Trial name
- AFACET (NCT03727724)
- Testing
- Afatinib, Cetuximab
- Where
- 4 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- The Netherlands Cancer Institute
NSCLC, Stage IV
Early Response Evaluation in NSCLC Patients Treated With Immunotherapy
A pilot study with biomarker exploration.50 patients with stage IV non-small cell lung cancer (NSCLC) that are eligible for treatment with nivolumab.
- Trial name
- NCT04082988
- Testing
- 18F-FDG PET-CT
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- The Netherlands Cancer Institute
Carcinoma, Non-Small-Cell Lung
ctDNA Guided Treatment of Early Resistance to Targeted Treatment
The current strategy is to test for treatment resistance at the time of radiological progression and design subsequent treatment based on the mechanism of resistance.
- Trial name
- TATIN (NCT04148066)
- Testing
- ctDNA blood sample
- Where
- 2 sites in Netherlands
- Volunteers
- 104 people
- Sponsor
- The Netherlands Cancer Institute
Non-small-cell Lung Carcinoma
Osimertinib Resistance in Patients With Non-small-cell Lung Carcinoma That Have Progressed.
Initially, patients with EGFR mutation positive NSCLC respond well to osimertinib, a third generation EGFR tyrosine kinase inhibitor (TKI), but eventually progress.
- Trial name
- OSIRIS (NCT04737382)
- Testing
- biopsy, ctDAN analysis
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer
Tracer-Guided Surgery for Recurrent Prostate Cancer
ADT with or without robot-assisted PSMA-radioguided surgery for patients with recurrent prostate cancer.
- Trial name
- Trace-II (NCT05555017)
- Testing
- PSMA-radioguided surgery, ADT
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- The Netherlands Cancer Institute
Penile Cancer
PEnile Cancer Radio- and Immunotherapy CLinical Exploration Study
Patients with advanced penile cancer have a poor prognosis (21% 2-year overall survival from moment of diagnosis) and high morbidity due to progressive locoregional disease.
- Trial name
- PERICLES (NCT03686332)
- Testing
- Arm A: Atezolizumab and Radiotherapy, Arm B: Atezolizumab
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Cancer
FAPI PET/CT for Lymph Node Staging in Colorectal Carcinoma
To describe the accuracy of FAPI PET/CT in the detection of regional lymph node metastases in patients with colorectal cancer in comparison with standard diagnostic imaging and (in operated patients) histopathology, aiming to…
- Trial name
- FAPI-CRC1 (NCT05209750)
- Testing
- FAPI PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- The Netherlands Cancer Institute
Epithelial Ovarian Cancer
Study With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian Cancer
The purpose of this study is to determine if patients with p53 mutated epithelial ovarian cancer that have been treated with first line treatment (paclitaxel - carboplatin combination therapy) and that have shown early relapse…
- Trial name
- M10MKO (NCT01164995)
- Testing
- MK-1775 and carboplatin
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- The Netherlands Cancer Institute
Melanoma
'Cancer Patients Better Life Experience'
The purpose of this study is to compare health-related quality of life, specifically fatigue, in melanoma patients treated with immunotherapy who use or do not use a patient-centered mobile coaching and monitoring system…
- Trial name
- CAPABLE (NCT05827289)
- Testing
- Cancer Patients Better Life Experience (CAPABLE)
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- The Netherlands Cancer Institute
Drug Adherence Marker
Subtherapeutic Dose of Piracetam as a Therapy Adherence Marker
The aim of this study is to test a subtherapeutic dose of piracetam in healthy volunteers as a marker of adherence to therapy to assess the feasibility of its use in a multicentre, randomised, double-blind, placebo-controlled…
- Trial name
- NCT05918341
- Testing
- Piracetam
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Lung Cancer Stage I, Lung Cancer Stage II
Cardiac Changes After Stereotactic Radiotherapy for Early Stage NSCLC Cancer or Lung Metastasis
The investigators aim to optimize the radiation treatment of early stage lung cancer patients. Therefore, detailed understanding is needed of the type of toxicity and the location of these toxicities for patients who receive high…
- Conditions
- Lung Cancer Stage I, Lung Cancer Stage II, Lung Metastases
- Trial name
- HALO (NCT03984019)
- Testing
- Cardiac condition measurements
- Where
- 3 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer, Solid Tumor, Adult
CYP3A4 Activity in Patients With Prostate Cancer Versus Male Patients With Other Solid Tumours
The hepatic enzyme, cytochrome P450 3A4 (CYP3A4) is important for the metabolism of many drugs including taxanes. Previous reported studies reported a decreases in docetaxel exposure in prostate cancer patients compared to…
- Trial name
- NCT05518799
- Testing
- Midazolam
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- The Netherlands Cancer Institute