Clinical trials: sponsored by The Netherlands Cancer Institute
Image-guide Surgery, Lymph Node Metastasis
Navigated Abdominal Lymph Node Dissections
Image-guided navigation surgery allows for full utilization of pre-operative imaging during surgery, and has the potential of reducing both irradical resections and morbidity.
- Trial name
- N16LND (NCT05867095)
- Testing
- Surgical navigation, Conventional
- Where
- Netherlands
- Volunteers
- 69 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Breast Implant; Complications
Association of Silicone Breast Implants With Overall Wellbeingand Auto-immune Diseases
Background: Implant-based breast reconstructions contribute considerably to the quality of life of breast cancer patients. A knowledge gap exists concerning the potential role of breast implants in the development of so called…
- Conditions
- Breast Cancer, Breast Implant; Complications, Autoimmune Diseases
- Trial name
- AREOLA-B (NCT05400954)
- Testing
- Breast reconstruction with silicone breast implant, Breast conserving surgery/Mastectomy/Autologous reconstruction, Breast Augmentation
- Where
- 7 sites in Netherlands
- Volunteers
- 15,000 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer Metastatic, Bone Metastases
Treatment Outcomes in a Non-study Population of Symptomatic mCRPC Patients Treated With Radium-223
This registry aims to evaluate the efficacy of Rad-223 treatment in a non-study population of CRPC patients treated earlier with Docetaxel and patients not treated earlier with Docetaxel and efficacy of the first subsequent…
- Trial name
- ROTOR (NCT03223727)
- Testing
- Blood tests
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Healthy Volunteers
Blood Sampling of Healthy Volunteers for Immunological Research
This protocol will be used to collect crucial components of the immune system from healthy volunteers for the characterization of immune cells in fresh blood.
- Trial name
- NCT03819829
- Testing
- Blood sample
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Surgical Injury, Stress, Physiological
Effect of a Bundle of Non-pharmacological Interventions on the Stress Response to Surgery
Rationale: Surgical trauma and post-surgical pain induce a physiological stress response that can be detrimental to the patient.
- Conditions
- Surgical Injury, Stress, Physiological, Stress, Psychological, Pain, Postoperative
- Trial name
- SPACU-lab (NCT05638152)
- Testing
- implementation of a bundle of non-pharmacological interventions aimed at stress reduction
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Locally Advanced Non-Small Cell Lung Cancer, Chemoradiotherapy
Upfront Resection of Locally Advanced NSCLC Followed by Chemoradiotherapy
For patients with irresectable locally advanced non-small cell lung cancer (NSCLC) (e.g. multilevel or bulky N2 disease or presence of N3 lymph node metastases), current guidelines recommend treatment with chemoradiotherapy (CRT)…
- Conditions
- Locally Advanced Non-Small Cell Lung Cancer, Chemoradiotherapy, Cavitation Lung, Surgery
- Trial name
- UPLAN-I (NCT05620199)
- Testing
- Upfront resection
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Organ Preservation, Rectal Cancer
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
The goal of this prospective phase II feasibility study is to evaluate two additional local treatment options in rectal cancer patients with a good clinical response after neoadjuvant (chemo)radiation: contact x-ray brachytherapy…
- Conditions
- Organ Preservation, Rectal Cancer, Quality of Life, Locally Advanced Rectal Carcinoma
- Trial name
- OPAXX (NCT05772923)
- Testing
- Contact x-ray brachytherapy, Local excision
- Where
- 7 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Testicular Cancer, Colorectal Neoplasms
Diagnostic Yield of Colonoscopy Surveillance in Testicular Cancer Survivors Treated With Platinum-based Chemotherapy
Testicular cancer (TC) survivors treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC) (hazard ratio (HR) 3.9 for platinum-containing chemotherapy versus no platinum-containing chemotherapy…
- Trial name
- CATCHER (NCT04180033)
- Testing
- Colonoscopy surveillance
- Where
- 4 sites in Netherlands
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
CRC, Advanced Neoplasia
Prospective Clinical Validation of a Novel Multitarget FIT in CRC Screening
The primary goal of the population-based colorectal (CRC) screening is early detection and interception of CRC and its precursors to decrease CRC-related morbidity and mortality.
- Trial name
- mtFIT (NCT05314309)
- Testing
- Comparison of two tests (FIT and mtFIT) in the same bowel movement
- Where
- Netherlands
- Volunteers
- 14,712 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Abdominal Cancer
Tracked Ultrasound for Patient Registration in Surgical Navigation During Abdominal Cancer Surgery
The goal of this observational pilot study is to evaluate the feasibility and accuracy of tracked ultrasound registration on patients undergoing abdominal cancer navigation surgery.
- Trial name
- NCT05637359
- Testing
- Tracked ultrasound measurement
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- The Netherlands Cancer Institute
Carcinoma, Non-Small-Cell Lung
T-DM1 and Osimertinib Combination Treatment to Target HER2 Bypass Track Resistance in EGFR Mutation Positive NSCLC
This is a single arm open-label multi-center phase II study, investigating disease control rate after 3 months of treatment with trastuzumab-emtansine/osimertinib combination therapy in patients with advanced EGFR mutation…
- Trial name
- TRAEMOS (NCT03784599)
- Testing
- Trastuzumab emtansine, Osimertinib
- Where
- 5 sites in Netherlands
- Volunteers
- 28 people
- Sponsor
- The Netherlands Cancer Institute
Bladder Carcinoma
EffectiveNess of a Multimodal preHAbilitation Program in patieNts With Bladder canCEr Undergoing Cystectomy
Currently, the potential value of a multimodal prehabilitation program in bladder cancer has not been extensively studied. The investigators designed the ENHANCE study to assess the effect of a structured multimodal…
- Trial name
- ENHANCE (NCT05480735)
- Testing
- Prehabilitation
- Where
- 8 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer Patients Undergoing Mastectomy With Immediate Reconstruction
Ultrasound-guided Erector Spinae Plane Block Versus Paravertebral Block in Breast Cancer Patients Undergoing Mastectomy With Immediate Reconstruction - a Non-inferiority Trial
The objective of this study is to assess the non-inferiority of analgesic efficacy of ESP vs PVB for patients undergoing unilateral mastectomy followed by immediate reconstruction.
- Trial name
- ESP (NCT05590559)
- Testing
- Morphine, Ultrasound-guided erector spinae plane block
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Head and Neck Cancer, Penile Cancer
INtra-operative Evaluation of a Novel FLUorescENt C-mEt Tracer in Penile and Tongue
In this study we evaluate the feasibility of intraoperative visualization of penile and tongue tumours using the fluorescent tracer EMI-137.
- Trial name
- INFLUENCE (NCT04574427)
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- The Netherlands Cancer Institute
Locally Advanced, Squamous Cell Carcinoma of the Vulva
Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)
Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease.
- Trial name
- VULCANize (NCT04192253)
- Testing
- Paclitaxel and Carboplatin
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- The Netherlands Cancer Institute
Metastatic Squamous Cell Carcinoma of the Vulva
Treatment of Metastatic Vulvar Carcinoma With Carboplatin and Paclitaxel Chemotherapy
Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease.
- Trial name
- CRAVAT (NCT04161664)
- Testing
- Paclitaxel and Carboplatin
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Neo Adjuvant Chemotherapy in Triple Negative Breast Cancer
This study aims to compare the response of triple-negative breast cancer with deficient homologous recombination to intensified alkylating chemotherapy versus standard chemotherapy with dose dense AC and/or Docetaxel-Capecitabine.
- Trial name
- neo-TN (NCT01057069)
- Testing
- Carboplatin and Paclitaxel, Doxorubicin, cyclophosphamide, Doxorubicin, cyclophosphamide, carboplatin, thiotepa, cyclophosphamide
- Where
- 14 sites in Netherlands
- Volunteers
- 310 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
High Dose Chemotherapy in Oligo-metastatic Homologous Recombination Deficient Breast Cancer
This study investigates the effect of high-dose alkylating chemotherapy compared with standard chemotherapy as part of a multimodality treatment approach in patients with oligo-metastatic breast cancer harboring homologous…
- Trial name
- Oligo (NCT01646034)
- Testing
- carboplatin, thiotepa, and cyclophosphamide, chemotherapy (docetaxel, doxorubicin, cyclofosfamide, carboplatin, paclitaxel, gemcitabine)
- Where
- Netherlands
- Volunteers
- 74 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside Tamoxifen
This study is designed as a phase 1 dose escalation study followed by a randomised phase II study. The study will be performed in three different centres: Addenbrooke \& Cambridge university (Cambridge, UK), Netherlands Cancer…
- Trial name
- Poseidon (NCT02285179)
- Testing
- GDC-0032, Tamoxifen
- Where
- 14 sites in France, Netherlands and 2 more
- Volunteers
- 189 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Cancer of the Breast
Pre- Versus Postoperative Accelerated Partial Breast Irradiation
Most of the local recurrences (LR) found after breast-conserving therapy are within or close to the tumor bed. This pattern of recurrence was confirmed by studies of breast conserving surgery without adjuvant irradiation and by…
- Conditions
- Breast Cancer, Cancer of the Breast, Neoplasms, Breast
- Trial name
- PAPBI-2 (NCT02913729)
- Testing
- partial breast irradiation
- Where
- 6 sites in France, Netherlands and 2 more
- Volunteers
- 65 people
- Sponsor
- The Netherlands Cancer Institute