Clinical trials: sponsored by Thomas Jefferson University
Preeclampsia
Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)
This proposal has three aims to characterize the relationship between aspirin therapy, platelet function response, and prevention of hypertensive disorders of pregnancy (HDP) through a prospective, cohort study using…
- Trial name
- APROACH (NCT04295850)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Thomas Jefferson University
Multiple Myeloma, Hodgkin Lymphoma
Mozobil for Autologous Hematopoietic Stem Cell Transplantation
This prospective trial investigates the approach of G-CSF with risk-adapted Plerixafor use for stem cell mobilization in patients undergoing autologous stem cell transplantation.
- Conditions
- Multiple Myeloma, Hodgkin Lymphoma, Non-hodgkin Lymphoma
- Trial name
- HSCT (NCT07188090)
- Testing
- Plerixafor, Gcsf
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Colorectal Carcinoma
A Community-Based Educational Intervention to Improve Colorectal Cancer Screening
This study investigates the facilitators and barriers to colorectal cancer screening in underserved populations with a focus on African American, Latinx, and Asian (Chinese) in the Sidney Kimmel Cancer Center catchment area.
- Trial name
- NCT04392050
- Testing
- Interview, Focus Group, Questionnaire Administration
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer
This phase I trial studies the side effects and best way to give enzalutamide, radiation therapy, and hormone therapy in treating patients with intermediate or high-risk prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer
- Trial name
- NCT02023463
- Testing
- Enzalutamide, Goserelin acetate, Leuprolide acetate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Thomas Jefferson University
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
MBC Physical Activity Study
This clinical trial evaluates the impact of a tailored physical activity program on physical activity in patients with breast cancer that has spread from where it first started to other places in the body (metastatic).
- Trial name
- NCT06500858
- Testing
- Exercise Intervention, Health Promotion and Education, Internet-Based Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas Jefferson University
Plasma Cell Myeloma
Home Based Daratumumab Administration for Patients With Multiple Myeloma
This clinical trial tests the treatment effect of home based daratumumab administration in treating patients with multiple myeloma.
- Trial name
- NCT05511428
- Testing
- Daratumumab and Hyaluronidase-fihj, Questionnaire Administration, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Congestive Heart Failure(CHF)
Ketone and Hawthorn Extract Supplementation in Congestive Heart Failure
The purpose of this research is to gain a better understanding of whether supplements can improve heart health. There are a number of study procedures and tests that will occur as a part of the research study.
- Trial name
- NCT07166965
- Testing
- Hawthorn supplement, Ketones
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Thomas Jefferson University
Stage IV Uveal Melanoma
SIR-Spheres® 90Y Microspheres Treatment of Uveal Melanoma Metastasized to Liver
The purpose of this study is to determine whether radiation provided locally to the liver tumor vasculature environment will demonstrate a response of tumor decline. This radiation may cause the tumor cells to die.
- Trial name
- NCT01473004
- Testing
- Sir-Spheres®
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Thomas Jefferson University
Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations
Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies
This phase II trial studies reduced-intensity conditioning before donor stem cell transplant in treating patients with high-risk hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations, Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2); GATA2, MECOM, Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214
- Trial name
- NCT01760655
- Testing
- Fludarabine phosphate, Busulfan, Total-Body Irradiation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Two Step Haplo With Radiation Conditioning
This phase II clinical trial evaluates whether a modified modality of conditioning reduces treatment-related mortality (TRM) in patients who undergo a hematopoietic stem cell transplant (HSCT) for a hematological malignancy.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Adult T-Cell Leukemia/Lymphoma, Aplastic Anemia
- Trial name
- NCT05031897
- Testing
- Fludarabine, Total-Body Irradiation, Donor Lymphocyte Infusion
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Thomas Jefferson University
Intrahepatic Cholangiocarcinoma
Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment
This phase II trial tests whether contrast-enhanced ultrasound can predict the response of bile duct cancer to targeted radiotherapy (radioembolization treatment).
- Trial name
- NCT05328167
- Testing
- Perflutren Protein-Type A Microspheres, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Thomas Jefferson University
Hot Flashes, Prostate Carcinoma
Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoing Antiandrogen Therapy
This pilot phase II trial studies how well vitamin B6 works in reducing hot flashes in participants with prostate cancer undergoing antiandrogen therapy.
- Trial name
- NCT03580499
- Testing
- Vitamin B6, Questionnaire Administration
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Multiple Myeloma, Plasma Cell Leukemia
Bendamustine Hydrochloride in Treating Patients With Previously Treated Multiple Myeloma
This phase I trial studies the side effects and best dose of bendamustine hydrochloride in treating patients with previously treated multiple myeloma.
- Trial name
- NCT02315157
- Testing
- Bendamustine
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Brain and Nervous System, Intracranial Neoplasm
Using a Head and Neck Maskless Immobilization Device For Patients With Intracranial Tumors
This pilot clinical trial studies how well head and neck maskless immobilization device works in immobilizing patients with head and neck cancers or intracranial tumors undergoing radiation therapy.
- Conditions
- Brain and Nervous System, Intracranial Neoplasm, Head and Neck Cancer
- Trial name
- NCT03076255
- Testing
- Computed Tomography, Medical Device, Cone-Beam Computed Tomography
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Type 2 Diabetes Mellitus (T2DM), Pregnancy
CGM Adherence Compared to Finger-stick Glucose Monitoring in Pregnancies With Type 2 Pregestational Diabetes
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM).
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Pregnancy, Continuous Glucose Monitoring System
- Trial name
- PRECIOUS (NCT07184775)
- Testing
- Continuous glucose monitor, Glucometer
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
Diabetes Mellitus, Type 2
Project MiNT: Assessing the Impact of Food & Video-Based Nutrition Education on Patients With Poorly Controlled Diabetes
This pragmatic randomized controlled trial will assess the efficacy of medically tailored meals and medical nutrition therapy via telehealth on clinical outcomes for patients with poorly controlled type 2 diabetes.
- Trial name
- NCT04264572
- Testing
- Medically Tailored Meals, Tele-Medical Nutrition Therapy (tele-MNT)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Thomas Jefferson University
Malignant Head and Neck Neoplasm
Evaluation of Sleep Quality in Head and Neck Cancer Patients Throughout Treatment Course
This study examines how head and neck cancer treatment affects quality of sleep over time and factors that contribute to sleep quality.
- Trial name
- NCT05108233
- Testing
- Survey Administration
- Where
- United States
- Sponsor
- Thomas Jefferson University
Head and Neck Cancer
Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer
Patients with advanced head and neck cancer is at high risk of recurrence at the primary site or in the neck. Part of normal treatment is to treat such patients with chemotherapy and radiation.
- Trial name
- NCT01326468
- Testing
- Temsirolimus, Cetuximab, Cisplatin
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Uveal Melanoma
Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma
This phase II trial studies how well stereotactic body radiation therapy and aflibercept work in treating patients with uveal melanoma.
- Trial name
- NCT03712904
- Testing
- Stereotactic Body Radiation Therapy, Ziv-Aflibercept
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Recurrent Head and Neck Carcinoma
Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer
This pilot clinical trial studies cesium Cs 131 brachytherapy in treating patients with head and neck cancer that has come back (recurrent) and can be removed by surgery.
- Trial name
- NCT02467738
- Testing
- Brachytherapy, Cesium-131, Conventional surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University