Clinical trials: sponsored by Thomas Jefferson University
Anxiety, Distress, Emotional
Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers
The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulation (TaVNS) in distressed persons who work in a…
- Conditions
- Anxiety, Distress, Emotional, Effects of Vibration, Healthy
- Trial name
- fMRIVNS (NCT05132881)
- Testing
- Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS), Waitlist Control, Healthy Controls: Substudy Group III
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Multiple Sclerosis
Physiological Effects of N-Acetyl Cysteine in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a disease in which the myelin surrounding the nerve cells is damaged which affects functioning. MS usually is treated with medications designed to reduce the occurrence of future MS events.
- Trial name
- MSNAC (NCT03032601)
- Testing
- N-acetyl Cysteine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Thomas Jefferson University
Refractory Status Epilepticus
Ketamine for the Treatment of Refractory Status Epilepticus
This pilot feasibility study aims to examine how the timing of ketamine introduction as a third-line anti-seizure medication infusion relates to seizure cessation in patients with refractory status epilepticus (RSE).
- Trial name
- NCT07177235
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Local Anesthetic Systemic Toxicity, Pain
Ropivacaine Pharmacokinetics in ESP Blocks
This is a pharmacokinetic study to determine risk of local anesthetic systemic toxicity of ropivacaine when used in erector spinae plane blocks for thoracic surgery.
- Conditions
- Local Anesthetic Systemic Toxicity, Pain, Quality of Recovery
- Trial name
- NCT04807504
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Rib Fractures
Analgesic Techniques for Rib Fractures
This study will be a 3-arm, parallel-group, randomized controlled trial comparing three analgesic techniques for rib fractures with a sample size of 24 patients (8 per group).
- Trial name
- NCT06519929
- Testing
- ESP block with catheter using ropivacaine (bolus followed by continuous infusion), Lidocaine bolus (1 mg/kg) and infusion starting at 1 mg/kg/h
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use
This trial studies how well an enhanced tobacco intervention protocol (ETIP) works compared to standard treatment in helping head and neck and lung cancer patients starting treatment to reduce cigarette use.
- Trial name
- NCT04694846
- Testing
- Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Spinal Cord Injuries, Spinal Cord Diseases
Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal
The objectives of this study are to (1) determine the effects of neuromodulation techniques on mobility in persons with chronic SCI, as measured by subjective and objective measures, and (2) to determine the optimal combination…
- Trial name
- RISES-T2 (NCT05994846)
- Testing
- RISES-T System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Prostate Carcinoma
Prostate Cancer Diagnosis by Multiparametric Ultrasound (Wholemount)
This phase III trial investigates if perflutren lipid microspheres with ultrasound can be used to diagnose prostate cancer non-invasively.
- Trial name
- NCT05336786
- Testing
- Perflutren Lipid Microspheres, Ultrasound
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
Lumbar Puncture
SHAPE for ICP Assessment
The Subharmonic Aided Pressure Estimation (SHAPE) technique is a noninvasive ultrasound-based imaging technique that can estimate ambient pressure using subharmonic emissions from ultrasound contrast agents.
- Trial name
- NCT06571786
- Testing
- Perflutren lipid microsphere
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Bladder Urothelial Carcinoma, Urothelial Carcinoma
Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy
This pilot clinical trial studies how well copper Cu-64 TP3805 positron emission tomography (PET)/computed tomography (CT) works in imaging patients with urothelial cancer undergoing surgery or biopsy.
- Trial name
- NCT03039413
- Testing
- Copper Cu 64 TP3805, Positron Emission Tomography, Computed Tomography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Head and Neck Carcinoma
Remote Activity Monitored by Fitbit Charge 3 in Investigating Daily Step and Sleep Data in Participants With Head and Neck Cancer Undergoing Radiation Therapy
This pilot trial studies remote activity monitored by Fitbit Charge 3 in investigating daily step and sleep data in participants with head and neck cancer who are undergoing radiation therapy.
- Trial name
- NCT03489252
- Testing
- Monitoring Device
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cervical Carcinoma, Malignant Female Reproductive System Neoplasm
Gynecological Sentinel Lymph Nodes CEUS
This clinical trial compares the use of ultrasound for the detection of sentinel lymph nodes (SLNs) to the standard of care (which varies depending on cancer treatment).
- Conditions
- Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Vaginal Carcinoma, Vulvar Carcinoma
- Trial name
- NCT05105087
- Testing
- Perflubutane Microbubble, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Jefferson University
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Recessive Dystrophic Epidermolysis Bullosa
Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC
This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC).
- Trial name
- NCT04177498
- Testing
- Rigosertib Sodium, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Thomas Jefferson University
Chronic Traumatic Brain Injury
PET-MRI in Chronic Traumatic Brain Injury (CTBI)
Chronic Traumatic Brain Injury (cTBI) symptoms exist in individuals who experienced previous traumatic brain injuries. There are 80-90 thousand individuals who are clinically diagnosed with cTBI, with estimated costs at greater…
- Trial name
- PET-MRIcTBI (NCT03241732)
- Testing
- Anti-inflammatory Diet, N-acetyl Cysteine, Neuro Emotive Technique
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Thomas Jefferson University
Parkinson Disease, Idiopathic Parkinson Disease
FDOPA PET and Nutritional Support in Parkinson's Disease
The overall goal of this study will be to further our understanding of how N Acetyl Cysteine (NAC) can help to support dopaminergic function in patients with Parkinson's disease (PD).
- Trial name
- FdopaPD2 (NCT04459052)
- Testing
- N acetyl cysteine, [F-18] Fluorodopa Positron Emission Tomography
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Advanced Hepatocellular Carcinoma, HCC
A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer
This is a Phase 2 Study of PD-0332991 in the treatment of patients with Advanced Hepatocellular Carcinoma (HCC), a type of adenocarcinoma and the most common type of liver tumor.
- Conditions
- Advanced Hepatocellular Carcinoma, HCC, Liver Cancer
- Trial name
- NCT01356628
- Testing
- PD-0332991
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Multiple Myeloma
Two Implementation Strategies for the Collection of Electronic Patient-Reported Outcomes Among Patients With Multiple Myeloma
This clinical trial evaluates satisfaction and engagement with a text messaging platform (TXT-Chatbot) compared to a patient portal system (MyChart/Patient Portal) for reporting symptoms among patients with multiple myeloma (MM).
- Trial name
- NCT06041698
- Testing
- Planned Notification, Survey Administration, Behavioral Intervention
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Thomas Jefferson University
Chronic Pain Syndrome
PET Imaging of Chronic Pain Syndromes
Central nervous system (CNS) changes associated with pain have been difficult to measure until the development of functional neuroimaging techniques such as positron emission tomography (PET).
- Trial name
- NCT03233594
- Testing
- Chiropractic Group, Healthy Control Group
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Thomas Jefferson University
Students, Spinal Cord Injury
Group Coaching Study for Life Goals
This study plans to implement's group coaching with neurodivergent STEM undergraduate students, individuals with spinal cord injuries and their caregivers, and individuals with Ehler's Danlos Syndrome.
- Conditions
- Students, Spinal Cord Injury, Ehlers Danlos Syndrome, Care Givers
- Trial name
- NCT07083713
- Testing
- Group Coaching
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University