Clinical trials: sponsored by Thomas Jefferson University
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Postpartum, VTE Prophylaxis
Excretion of Rivaroxaban in Human Breast Milk
The purpose of this study is to investigate the distribution of rivaroxaban into human milk at both therapeutic and prophylactic doses, and over time with repeated dosing.
- Conditions
- Postpartum, VTE Prophylaxis, VTE (Venous Thromboembolism), Rivaroxaban
- Trial name
- LACT (NCT06831474)
- Testing
- Rivaroxaban 10 MG Oral Tablet, Rivaroxaban 20 MG Oral Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Preterm Birth, Preeclampsia
Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes…
- Trial name
- DASH (NCT06826859)
- Testing
- Daily aspirin (ASA), Split dose aspirin (ASA)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Thomas Jefferson University
Erectile Dysfunction, Localized Prostate Carcinoma
LiSWT for Nerve Sparing Radical Prostatectomy ED
This phase I clinical trial studies how well low intensity shockwave therapy (LiSWT) improves erectile function in patients who have had nerve-sparing radical prostatectomy (NS-RP), a type of surgery that attempts to save the…
- Conditions
- Erectile Dysfunction, Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
- Trial name
- NCT05877144
- Testing
- Nerve-Sparing Prostatectomy, Medical Device Usage and Evaluation, Duplex Ultrasound
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Thomas Jefferson University
Metastatic Uveal Melanoma
Defactinib and VS-6766 for the Treatment of Patients With Metastatic Uveal Melanoma
This phase II trial studies the effect of combining defactinib and VS-6766 in treating patients with uveal melanoma that has spread to other places in the body (metastatic).
- Trial name
- NCT04720417
- Testing
- Defactinib Hydrochloride, Raf/MEK Inhibitor VS-6766, Biopsy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Thomas Jefferson University
Elbow Tendinopathy, Tendinopathy
Measuring Pain Experience in Individuals With Lateral Elbow Tendinopathy
The study will address the gaps in the pain experience measurement in those with lateral elbow tendinopathy (LET) by building on the current body of literature, as well as applying modern pain science measures.
- Conditions
- Elbow Tendinopathy, Tendinopathy, Tennis Elbow
- Trial name
- NCT06025565
- Testing
- Pain Experience Measures
- Where
- 16 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
Ductal Breast Carcinoma in Situ, Invasive Ductal Breast Carcinoma
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy
This pilot clinical trial studies caloric restriction in patients with stage 0-I breast cancer during surgery and radiation therapy. Reducing caloric intake may prevent disease progression in patients with breast cancer.
- Conditions
- Ductal Breast Carcinoma in Situ, Invasive Ductal Breast Carcinoma, Invasive Lobular Breast Carcinoma, Lobular Breast Carcinoma in Situ
- Trial name
- CAREFOR (NCT01819233)
- Testing
- Behavioral dietary intervention, Therapeutic conventional surgery, Radiation therapy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
AML
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)
The purpose of this study is to evaluate the addition of Sirolimus (rapamycin) to standard chemotherapy for the treatment of patients with high risk acute myelogenous leukemia (AML).
- Trial name
- NCT01184898
- Testing
- Sirolimus, Mitoxantrone, Etoposide
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hematologic Malignancies, Acute Leukemia
Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps
This is a research study involving the treatment of patients with hematological cancers with allogeneic (cells from a donor) hematopoietic stem cell transplant (HSCT). HSCT is often referred to as bone marrow transplant.
- Conditions
- Hematologic Malignancies, Acute Leukemia, Myelodysplastic Syndromes (MDS) Other Than RA or RARS Subtypes, Hodgkin's Lymphoma
- Trial name
- NCT01350258
- Testing
- Fludarabine, Thiotepa, Total Body Irradiation (TBI)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Measuring the Impact of MANNA s Medically Tailored Meal Program in Patients With a Non-terminal Cancer Diagnosis
This study identifies patient-important outcome measures and develops a survey that assesses the impact of nutritional interventions among cancer patients.
- Trial name
- NCT05118802
- Testing
- Interview, Survey Administration
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Caregiver, Malignant Neoplasm
A Computer-Based System for Symptom Reporting in Patients With Cancer Undergoing Treatment
This pilot trial studies the usability and usefulness of a computer-based system for reporting symptoms in patients with cancer undergoing treatment.
- Trial name
- NCT03979846
- Testing
- Best Practice, Computer Application, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Breast - Female
Educational Module and Decision Counseling Program in Increasing Mammography Screening Rates in Formerly Homeless Women With Serious Mental Illness
This pilot clinical trial studies how well an educational module and decision counseling program works in increasing mammography screening rates in formerly homeless women with serious mental illness.
- Trial name
- NCT03162887
- Testing
- Educational Intervention, Counseling, Informational Intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Head and Neck Carcinoma, Hypopharyngeal Carcinoma
Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment
This clinical trial evaluates the tolerability of a physical activity program in head and neck cancer patients who are undergoing cancer treatment.
- Conditions
- Head and Neck Carcinoma, Hypopharyngeal Carcinoma, Laryngeal Carcinoma, Maxillary Sinus Carcinoma
- Trial name
- NCT04788264
- Testing
- Medical Device Usage and Evaluation, Consultation, Exercise Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas Jefferson University
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Evaluation of Barriers to Cancer Care Delivery and Outcomes for Women of Color With Metastatic Breast Cancer
This study evaluates disparities and barriers in cancer care delivery and outcomes in women of color by identifying socioeconomic variables that may be related to the inequity.
- Trial name
- NCT06206239
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Thomas Jefferson University
Lung Cancer
Proactive Outreach and Shared Decision Making in Improving Lung Cancer Screening Rates in Primary Care Patients
This trial studies how well proactive outreach and shared decision making works in improving lung cancer screening rates in primary care patients.
- Trial name
- NCT03929926
- Testing
- Best Practice, Cancer Educational Materials, Behavioral, Psychological or Informational Intervention
- Where
- United States
- Volunteers
- 2,355 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Head and Neck Carcinoma
Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC)
This pilot clinical trial studies the effects of a low carbohydrate diet on tumor metabolism in patients with head and neck cancer.
- Trial name
- NCT02555176
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Lung Carcinoma
Improving Lung Cancer Screening Adherence by Overcoming Barriers for Vulnerable Populations
This study investigates multi-level barriers to lung cancer screening uptake and adherence to lung cancer screening. Identifying cost- and convenience-related barriers to lung cancer screening may help researchers develop…
- Trial name
- NCT04969341
- Testing
- Survey Administration, Electronic Health Record Review
- Where
- United States
- Volunteers
- 947 people
- Sponsor
- Thomas Jefferson University
Liver Cirrhosis
Contrast-Enhanced Ultrasound Imaging in Diagnosing Liver Cancer in Patients With Cirrhosis
This clinical trial studies how well contrast-enhanced ultrasound imaging works in diagnosing liver cancer in patients with cirrhosis.
- Trial name
- NCT03318380
- Testing
- Dynamic Contrast-Enhanced Ultrasound Imaging
- Where
- 11 sites in United States, Canada and 4 more
- Volunteers
- 612 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Esophagus
Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer
This pilot trial studies how well an ultrasound with a contrast agent (perflubutane microbubble [Sonazoid]) works in identifying sentinel lymph nodes in participants with esophageal cancer.
- Trial name
- NCT03578224
- Testing
- Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA), Contrast-Enhanced Ultrasound, Fine-Needle Aspiration
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Malignant Neoplasm
Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This phase II trial studies how well haploidentical donor hematopoietic stem cell transplant works in treating patients with hematologic malignancies.
- Trial name
- NCT01871441
- Testing
- Total-body irradiation, Donor lymphocytes infusion (DLI), Cyclophosphamide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University