Clinical trials: open to volunteers, sponsored by Thomas Jefferson University
Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
The Use of Contrast Enhanced Ultrasound (CEUS) In Post-Surgical Pancreatic Cancer Patients to Evaluate Local Disease Recurrence
This pilot study is testing whether a special type of ultrasound called contrast-enhanced ultrasound (CEUS) can help detect if pancreatic cancer has come back after surgery.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer, Local Disease
- Trial name
- NCT07910383
- Testing
- Lumason, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8
Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network
This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started…
- Conditions
- Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT05627219
- Testing
- Training and Education, Educational Intervention, Discussion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Stress Urinary Incontinence
Feasibility of Resisted Expiratory Muscle Training for Females Assigned at Birth With Stress Urinary Incontinence: A Pilot Study
The goal of this randomized pilot study is to determine whether adding expiratory muscle strength training (EMST) to standard pelvic floor muscle training (PFMT) is feasible and may help improve stress urinary incontinence (SUI)…
- Trial name
- NCT07905586
- Testing
- Pelvic floor muscle training, Expiratory muscle strength training
- Volunteers
- 24 people
- Sponsor
- Thomas Jefferson University
Solid Tumor Cancer, Immune-Related Adverse Events
Cancer Nutrition Study - A Study of Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors
The goal of this clinical trial is to learn whether changing the diet can help improve gut health and support recovery from immune-related side effects caused by immune checkpoint inhibitor (ICI) cancer treatment in adults with…
- Trial name
- CaNS (NCT07804225)
- Testing
- High-Fermented Food Diet, HI-MAIZE 260 Resistant Starch
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Head and Neck Cancer, Head and Neck Small Cell Carcinoma
Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer
This is a feasibility trial studying anti-PD-1 therapy (Pembrolizumab) among patients with R/M HNSCC, delivered with ultrasound-induced microbubble cavitation, with the goal of optimizing delivery of Pembrolizumab and tumor…
- Conditions
- Head and Neck Cancer, Head and Neck Small Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
- Trial name
- NCT07501650
- Testing
- Pembrolizumab, Definity, Ultrasound-Induced Microbubble Cavitation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Thomas Jefferson University
Colorectal Cancer, Small Bowel Adenocarcinoma
GUCY2C Prime-Boost Vaccination for Advanced Colorectal and Small Bowel Adenocarcinomas
This is an open-label, non-randomized, single-center, dose-escalation Phase 1 trial using a heterologous prime-boost strategy of vaccination with Ad5.F35-hGUCY2C-PADRE and recombinant Listeria monocytogenes (Lm-GUCY2C) vaccines…
- Trial name
- NCT07417488
- Testing
- Ad5.F35-hGUCY2C-PADRE vaccine, Lm-GUCY2C vaccine, CT Scan
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Thomas Jefferson University
Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8
Peer Navigation for the Support of Metastatic Prostate Cancer Patients Undergoing Genetic Evaluation
This clinical trial evaluates whether having a trained peer navigator helps African American men with prostate cancer that has spread to other parts of the body (metastatic) understand and navigate the genetic testing process…
- Conditions
- Metastatic Prostate Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
- Trial name
- NCT05487846
- Testing
- Patient Navigation, Genetic Counseling, Survey Administration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Lung Cancer
Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)
The goal of this observational study is to learn whether a urine-based test that measures volatile organic compounds (VOCs) can help detect lung cancer in people who have never smoked.
- Trial name
- NCT07871656
- Testing
- Biosensor Platform
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Thomas Jefferson University
Ventral Hernia, Ventral Incisional Hernia
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery
Ventral hernia repair is among the most common operations performed in the United States each year, yet the great majority of patients receive no structured rehabilitation for the persistent pain, weakness, and functional loss…
- Conditions
- Ventral Hernia, Ventral Incisional Hernia, Post Operative Pain
- Trial name
- IMPACT (NCT07145099)
- Testing
- PT Group, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Stiff Person Syndrome
VYVGART (Hytrulo) in Patients With Stiff Person Syndrome (SPS)
Stiff Person Syndrome (SPS) is a rare autoimmune disorder, characterized by: a) incapacitating diffuse muscle stiffness prominent in the axial, abdominal and thoracolumbar paraspinal muscles leading to hyperlordosis, difficulty…
- Trial name
- NCT07860021
- Testing
- VYVGART Hytrulo
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Thomas Jefferson University
Liver Diseases, Portal Hypertension
Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal
This is an open-label, non-randomized trial that will be conducted at three clinical sites, Thomas Jefferson University (TJU), the Hospital of the University of Pennsylvania (HUP) and University of Bern (UB).
- Trial name
- NCT05470205
- Testing
- SHAPE measurement (Sonazoid ultrasoud contrast agent), SHAPE measurement (Definity ultrasoud contrast agent)
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 660 people
- Sponsor
- Thomas Jefferson University
Diagnostic Uncertainty
Targeted EHR-based Communication of Diagnostic Uncertainty in the ED
The goal of the clinical trial is to evaluate the preliminary effectiveness and the implementation feasibility of the Targeted EHR-based Communication about Uncertainty (TECU) strategy in improving the quality of care transitions…
- Trial name
- TECU (NCT06638021)
- Testing
- Targeted EHR-based Communication of Diagnostic Uncertainty (TECU)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Ovarian Cancer, Adnexal Lesion
Contrast-enhanced Ultrasound Evaluation of Indeterminate Ovarian Lesions: Prospective Multicenter Study
The goal of this clinical trial is to learn how well contrast-enhanced ultrasound (CEUS) can diagnose ovarian cancer in patients with indeterminate or suspicious ovarian/adnexal lesions identified on routine ultrasound or MRI.
- Trial name
- NCT07849543
- Testing
- Contrast-Enhanced Ultrasound (CEUS)
- Volunteers
- 190 people
- Sponsor
- Thomas Jefferson University
Obstructive Sleep Apnea
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation.
- Trial name
- NCT04191512
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Periprosthetic Joint Infection (PJI)
Periprosthetic Joint Infection Bubble Study
Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control…
- Trial name
- PJI (NCT07599865)
- Testing
- Ultrasound-triggered microbubble destruction with antibiotics
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Time Restricted Eating for the Improvement of Outcomes in Patients With Stage I-III Breast Cancer Receiving Chemotherapy Before Surgery
This phase II trial studies whether time restricted eating (TRE) works to improve outcomes in patients with stage I-III breast cancer receiving chemotherapy before surgery (neoadjuvant) with a body mass index (BMI) 25-40.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Invasive Breast Carcinoma
- Trial name
- NCT05327608
- Testing
- Short-Term Fasting, Chemotherapy, Biospecimen Collection
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Thomas Jefferson University
Prostate Carcinoma
Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer
This phase III trial compares the use of contrast-enhanced multiparametric ultrasound (mp-US) to multiparametric magnetic resonance imaging (mp-MRI) for the diagnosis of clinically significant prostate cancer (PCa).
- Trial name
- NCT06024772
- Testing
- ultiparametric Magnetic Resonance Imaging, Perflutren lipid microsphere, Transrectal Ultrasound
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
Hormone Receptor Positive Breast Carcinoma, Postmenopausal
Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia
The objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa.
- Conditions
- Hormone Receptor Positive Breast Carcinoma, Postmenopausal, Breast Cancer
- Trial name
- NCT07737951
- Testing
- Tai Chi, Health Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Prostate Cancer, Metastatic Castrate Resistant Prostate Cancer
LuX: Xaluritamig in Participants With Metastatic Castrate Resistant Prostate Cancer and Suboptimal Response to Lutetium 177 Vipivotide Tetraxetan
This is a phase 2a, open label, single arm, multi-site study of xaluritamig in mCRPC patients following treatment with ≥1 ARPI, taxane chemotherapy (if eligible) and stable or partial PSA response following 2 cycles of lutetium…
- Trial name
- NCT07737925
- Testing
- Xaluritamig
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University