Clinical trials: sponsored by Turku University Hospital
Female Genital Prolapse
Single Incision Transvaginal Mesh in Treatment of Posterior Vaginal Wall Prolapse
Definition: To find out complications, objective and subjective outcomes of patients with symptomatic posterior vaginal wall prolapse undergoing posterior mesh operation in nine Finnish hospitals during September 2010 and August…
- Trial name
- NCT02092623
- Testing
- Transvaginal posterior mesh
- Where
- Finland
- Volunteers
- 111 people
- Sponsor
- Turku University Hospital
Cardiomyocyte Apoptosis
Cardiomyocyte Apoptosis Following Antegrade and Retrograde Cardioplegia
Retrograde cardioplegia during heart surgery is associated with inadequate myocardial protection. In experimental animal study retrograde cardioplegia induces more cardiomyocyte apoptosis when compared to antegrade cardioplegia.
- Trial name
- NCT01185912
- Testing
- Ventricle muscle tissue samples
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Brain Injuries, Skull Fractures
Association Between Craniofacial Fractures and Brain Injuries: Diagnostic and Therapeutic Considerations
This study evaluates the association between traumatic brain injuries and craniofacial or/and skull fractures. Purpose is to find out the amount of missed diagnoses and improve primary diagnostics of trauma patients.
- Trial name
- NCT02418169
- Volunteers
- 1,000 people
- Sponsor
- Turku University Hospital
Pelvic Organ Prolapse
Polypropylene Mesh in Prolapse Surgery
The purpose of this study was to report the long-term objective and subjective outcome after prolapse surgery with polypropylene mesh.
- Trial name
- NCT02383199
- Volunteers
- 161 people
- Sponsor
- Turku University Hospital
Risk Factors for Age Related Macular Degeneration
Effects of Sea Buckthorn Oil and Lutein on Eye Health
Low macular pigment optical density has been associated with increased risk of age-related macular degeneration, an important cause of vision problems in the elderly population.
- Trial name
- SBEYE (NCT02379169)
- Testing
- Sea buckthorn oil & lutein
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Glaucoma, Open-Angle, Ocular Hypertension
Evaluation of Rate of Progression With Perimetry in Newly Diagnosed Open Angle Glaucoma
The purpose of this study is to evaluate rate of progression in newly diagnosed open angle glaucoma with different types of perimetry.
- Trial name
- NCT02379208
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Generalized Visual Field Contraction or Constriction
A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph
The study is aimed to develop a new reaction-time based method for examining the visual field and to study the effect of refractive error on the magnification of a fundus photograph in order to evaluate the true size of a retinal…
- Trial name
- NCT01843582
- Where
- Finland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cranial Bone Defect, Orbital Base Fracture
Clinical Study of FRC Implant to Treat Skull Bone Defects
Bioactive fibre-reinforced composite implant is used for reconstruction of skull bone defects and orbital floor defects. Functional and aesthetic outcome is assessed by patient and doctor.
- Trial name
- Cranio-2 (NCT01874613)
- Testing
- FRC implant reconstruction
- Where
- Finland
- Volunteers
- 19 people
- Sponsor
- Turku University Hospital
Ischemic Brain Injury
Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients
The main purpose of this study is to explore whether xenon is neuroprotective in humans. In addition, the purpose is to explore the underlying mechanisms for the possible synergistic neuroprotective interaction of xenon and…
- Trial name
- Xe-hypotheca (NCT00879892)
- Testing
- xenon, Hypothermia
- Where
- 10 sites in United States, Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Gestational Diabetes
Metformin Versus Insulin in Gestational Diabetes
Gestational diabetes is traditionally treated with insulin. Metformin is a peroral drug used worldwide in the treatment of type 2 diabetes and also in a few studies on patients with gestational diabetes.
- Trial name
- NCT01240785
- Testing
- metformin, insulin
- Volunteers
- 221 people
- Sponsor
- Turku University Hospital
Healthy
Effects of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sublingual and Intravenous Buprenorphine
This study is aimed to examine the possible interactions of sublingual and intravenous buprenorphine with rifampicin.
- Trial name
- NCT01854489
- Testing
- Rifampicin, Buprenorphine
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Colorectal Cancer
Treatment Monitoring of Advanced Colorectal Cancer With 18F-FDG PET/CT
Measuring tumor response to treatment based on computed tomography (CT) and/or magnetic resonance imaging (MRI) has been a widely debated issue (response criteria in solid tumors [RECIST] and World Health Organization criteria).
- Trial name
- RESCORE (NCT00823810)
- Testing
- PET/CT
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Abdominal Hysterectomy (& Wertheim)
Clinical Follow up After Subtotal and Total Hysterectomy
The purpose of this study was to find out subjective and objective outcomes of patients undergoing subtotal or total abdominal hysterectomy during a follow up of a mean 33 years after the operation.
- Trial name
- NCT02166749
- Testing
- Subtotal abdominal hysterectomy
- Where
- Finland
- Volunteers
- 212 people
- Sponsor
- Turku University Hospital
Pelvic Organ Prolapse
Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
- Trial name
- NCT01749696
- Where
- Finland
- Volunteers
- 78 people
- Sponsor
- Turku University Hospital
Bone Metastases
Imaging of Prostate and Breast Cancer Bone Metastases Using Magnetic Resonance Imaging and Nuclear Medicine Techniques
Prostate and breast cancer continues to be the most common cancer among men and women, respectively. The exact assessment of the cancer spread with detection of possible bone metastasis is crucial for treatment decision.
- Trial name
- NCT01339780
- Testing
- BS, SPECT/CT, PET/CT, MRI
- Where
- Finland
- Volunteers
- 53 people
- Sponsor
- Turku University Hospital
Neoplasms, Pancreatic Cancer
PET-CT in Diagnosis of Pancreatic Cystic Neoplasms
Preoperative diagnosis of pancreatic cystic lesions remains a difficult problem in clinical practice. At present, the treatment planning in pancreatic cystic neoplasms is significantly restricted by the limited preoperative…
- Trial name
- NCT01317836
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Turku University Hospital
Ankle Fracture
Ankle Syndesmosis Fixation by Antibiotic Releasing Bioabsorbable Screw
This single-center randomized trial evaluates the efficacy and safety of a new bone screw (antibiotic releasing bioabsorbable screw) in fixation of syndesmosis in patients with Weber C-type ankle fractures.
- Trial name
- NCT01729195
- Testing
- A ciprofloxacin containing bioabsorbable PLGA bone screw
- Where
- Finland
- Volunteers
- 17 people
- Sponsor
- Turku University Hospital
Glioma
Imaging Malignant Glioma With 68Ga-DOTATOC PET/CT
The purpose of this study is to characterize tumour uptake of somatostatin analog 68Ga-DOTATOC in patients with either primary or recurrent malignant glioma.
- Trial name
- DOTAGLI (NCT01460706)
- Testing
- [68Ga]DOTATOC
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Comparison Between Effectiveness of Lumbar Fusion and Conservative Treatment
Lumbar Fusion Compared With Conservative Treatment in Patients With Chronic Low Back Pain: a Meta-analysis
To determine the effect size of lumbar fusion measured by Oswestry Disability Index and compared with conservative treatment in patients with chronic low back pain. Meta-analysis using fixed effect model synthesis method.
- Trial name
- NCT01780194
- Volunteers
- 666 people
- Sponsor
- Turku University Hospital
Atraumatic Rotator Cuff Rupture
Treatment of Atraumatic Rotator Cuff Rupture in Elderly Patients
The purpose of the investigators study is to compare the effect of: 1) physiotherapy 2) arthroscopic acromioplasty and debridement or 3) arthroscopic rotator cuff reconstruction and acromioplasty in the treatment of degenerative…
- Trial name
- toarcriep (NCT01116518)
- Testing
- physiotherapy, acromioplasty, acromioplasty and rotator cuff reconstruction
- Where
- 3 sites in Finland
- Volunteers
- 180 people
- Sponsor
- Turku University Hospital