Clinical trials: sponsored by Turku University Hospital
Sleep Apnea
Muscle Strength Exercise and Sleep Apnea
Background: Obstructive sleep apnea is one of our common diseases and up to 80% of patients are estimated to be undiagnosed. Its main risk factors are overweight, age, male gender, menopause, small jaw, sedative medications /…
- Trial name
- NCT05320952
- Testing
- WellO2
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Healthy Newborn Infants
Resilience to Antibiotic-induced Obesogenic Microbiota: Discovering Mechanism of Microbiota Modulation
The aim is to study whether the microbiota of children who are exposed to antibiotics at birth could be modified by synbiotic supplement and thereby reduce the risk of obesity, chronic diseases and respiratory tract infections.
- Trial name
- ReCoverHealth (NCT06974994)
- Testing
- Synbiotic Supplement
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Turku University Hospital
Tooth Loss
3D Autotransplantation of Teeth
The study aims to clarify the usefulness of 3D-printed replicas in association with autotransplantation of teeth in children and young adults.
- Trial name
- NCT04120688
- Testing
- 3D generated tooth replica
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Adolescent Idiopathic Scoliosis (AIS), Neuromuscular Scoliosis
Pooled Human Plasma vs Crystalloid in The Management of Children Undergoing Instrumented Spinal Fusion for Scoliosis
OCTAGON trial is a randomized, double-blinded, parallel-group non-inferiority multicenter (Helsinki and Turku University Hospitals, Finland) clinical trial according to CONSORT criteria.
- Trial name
- OCTAGON (NCT06934278)
- Testing
- Pooled human plasma
- Where
- 2 sites in Finland
- Volunteers
- 194 people
- Sponsor
- Turku University Hospital
Colitis
Intestinal Microbiome and Chronic Inflammatory Bowel Disease
The aim is to examine the role of intestinal microbiota in the pathogenesis of chronic inflammatory bowel diseases (IBD)
- Trial name
- NCT02768038
- Testing
- Observational
- Where
- Finland
- Sponsor
- Turku University Hospital
Acute Rotator Cuff Tear Related to Trauma
ACCURATE Trial - Operative Treatment of Acute Rotator Cuff Tear Related to Trauma
Rotator cuff tear is a very common and disabling condition that can be related to acute trauma such as falling on the shoulder. A tear is associated with symptoms such as pain in abduction, abduction weakness and night pain.
- Trial name
- NCT02885714
- Testing
- Rotator cuff repair and supervised specific exercises
- Where
- 17 sites in Finland, Norway and 1 more
- Volunteers
- 180 people
- Sponsor
- Turku University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury
Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage
An investigator-initiated clinical drug study Main Objective: To explore neuroprotective properties of xenon in patients after aneurysmal subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury, Cerebral Ischemia, Cerebral Infarction
- Trial name
- Xe-SAH (NCT04696523)
- Testing
- Xenon, air/oxygen
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Tonsillar Hypertrophy, Sleep Apnea, Obstructive
Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
Treating sleep apnea in adults caused by tonsillar hypertrophy with intracapsular tonsillectomy by coblation
- Trial name
- NCT04314492
- Testing
- Tonsillectomy
- Where
- 2 sites in Finland
- Volunteers
- 25 people
- Sponsor
- Turku University Hospital
Chronic Kidney Disease, Cardiovascular Diseases
SEDentary Lifestyle, Mortality and Major Adverse Clinical Outcomes in Chronic KIDney Disease
The goal of this study is to learn if a simple home exercise program can benefit patients with advanced chronic kidney disease. There is also an observational part of the study without an exercise program.
- Conditions
- Chronic Kidney Disease, Cardiovascular Diseases, Frailty
- Trial name
- SEDKID (NCT06935786)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- 3 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging
This is an open, follow-up study to compare the performance of three critical imaging methods to detect chronic active lesions in Multiple Sclerosis (MS) in vivo.
- Trial name
- SELPET (NCT06460077)
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Turku University Hospital
Cancer, Hearing Loss Ototoxic
The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life
The study will assess the effect of cancer treatments on speech perception in noise, cognition, and hearing-related quality of life by monitoring 200 cancer patients receiving standard care for their underlying malignancy.
- Conditions
- Cancer, Hearing Loss Ototoxic, Cognitive Decline, Quality of Life
- Trial name
- CaSPiN (NCT06551857)
- Testing
- Chemotherapy, chemoradiation, radiation therapy
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression
To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.
- Trial name
- TERIPET (NCT03368677)
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Turku University Hospital
Parkinson Disease, Parkinsonism
Non-motor Symptoms and Brain Dopamine Transporter Binding
This project aims to clarify the role non-motor symptoms in the development of Parkinson's disease (PD) and to improve diagnostics at very early stages of PD.
- Trial name
- NMDAT (NCT02650843)
- Testing
- DAT SPECT imaging
- Volunteers
- 455 people
- Sponsor
- Turku University Hospital
Pain, Postoperative, Anesthesia, Local
Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery
This study aims to investigate the effect of transversus thoracis muscle plane block (TTP), using repeated boluses of ropivacaine via catheter, on postoperative pain and oxycodone consumption after elective cardiac surgery with…
- Conditions
- Pain, Postoperative, Anesthesia, Local, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- TTPcat (NCT04916418)
- Testing
- Ropivacaine
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Clostridioides Difficile Infection
FMT in Initial CDI
The study explores fecal microbiota transfer via retention enema after the first clostridioides difficile episode.
- Trial name
- FinCDI (NCT05257538)
- Testing
- FMT
- Where
- Finland
- Volunteers
- 140 people
- Sponsor
- Turku University Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Virtual Pulmonary Rehabilitation Program for COPD Patients; a Pilot Study
The goal of this pilot study is to investigate the feasibility of a virtual rehabilitation program in COPD patients. The main questions it aims to answer are: 1.
- Trial name
- e-PURE (NCT06915740)
- Testing
- Exercise
- Where
- 2 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
Small Bowel Crohn's Disease
Combined [18F]-FDG PET-MRI in Diagnostics and Surveillance of Small Bowel Crohn's Disease
Patients with suspected small bowel Crohn's disease (CD) are assessed with PET-MRE using 18-fluorodeoxyglucose ([18F]-FDG) tracer.
- Trial name
- CD-PET (NCT06796959)
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Turku University Hospital
Knee Osteoarthritis, Pain, Postoperative
Premedication with Intranasal Dexmedetomidine in Sedation of Patients Undergoing Total Knee Arthroplasty
This study aims to find out if preoperatively given dexmedetomidine is effective analgesic adjuvant for treating postoperative pain in patients undergoing elective total knee arthroplasty (TKA).
- Trial name
- TKADEX (NCT04859283)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
High Grade Ovarian Serous Adenocarcinoma, High Grade Serous Carcinoma
Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC
Chemotherapy resistance is the greatest contributor to mortality in advanced cancers and severe challenges remain in finding effective treatment modalities to cancer patients with metastasized and relapsed disease.
- Trial name
- DECIDER (NCT04846933)
- Testing
- WGS and RNA sequencing, circulating tumor DNA (ctDNA), FDG PET/CT imaging
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Turku University Hospital