Clinical trials: sponsored by Turku University Hospital
Multiple Sclerosis
Effect of Cladribine Treatment on Microglial Activation in the CNS
To evaluate the effect of cladribine treatment on microglial activation with conventional MRI, QSM-post processing and TSPO-PET imaging in late stage relapsing remitting multiple sclerosis patients.
- Trial name
- CLADPET (NCT04239820)
- Testing
- Imaging
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Multimodal Imaging of MS Reveals the Smoldering Inflammation
To evaluate active MS plaque evolution with conventional MRI, QSM-post processing, TSPO-PET imaging and P2X7-PET imaging.
- Trial name
- PLAQ-MS (NCT04126772)
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity
Weight Load PET (WELPET)
Obesity related ailments, such as cardiovascular diseases (CVD) and metabolic disorders are major causes of death in the world. This trial may result in improved understanding of the causes of obesity and obesity-related…
- Trial name
- WELPET (NCT05443620)
- Testing
- Weight vest, Wheelchair
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pelvic Organ Prolapse, Cystocele
Native Tissue Repair in Pelvic Organ Prolapse -Long-term Results and Risk of Re-operation
This study evaluates the recurrence of pelvic organ prolapse and the rate of re-operation after primary surgery for anterior vaginal wall prolapse with native tissue repair in long term follow-up.
- Trial name
- NCT06744972
- Volunteers
- 392 people
- Sponsor
- Turku University Hospital
Obesity and Overweight
Total-body Glucose Utilization in Obesity
There are three goals for this study. One is to investigate how different emotions and exposure to cold affect blood flow in the body.
- Trial name
- TOTAL (NCT06739473)
- Testing
- Movies, Cold, Hyperinsulinemic euglycemic clamp
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Anorexia Nervosa
Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction
The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging)…
- Trial name
- AVAIN-PET (NCT05101538)
- Where
- Finland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Olecranon Fracture
Scandinavian Olecranon Research in the Elderly
This study is designed to study the difference between operative treatment, either with tension band wiring or plate fixation, and conservative treatment of traumatic, displaced olecranon fractures in elderly population in a…
- Trial name
- NCT04401462
- Testing
- Tension band wiring or plate fixation, Sling or a long-arm plaster
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Myeloid Leukemia, Melanoma
PET Imaging of Cancer Patients Using 68Ga-DOTA-Siglec-9
This is a scientific study to determine expression of vascular adhesion protein 1 (VAP-1) in cancer patients by 68Ga-DOTA-Siglec-9 positron emission tomography/computed tomography (PET/CT) before and after cancer treatment.
- Conditions
- Acute Myeloid Leukemia, Melanoma, Non Small Cell Lung Cancer
- Trial name
- CANSI (NCT05212103)
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Turku University Hospital
Epithelial Ovarian Cancer, Peritoneal Cancer
Epithelial Ovarian Cancer- Staging and Response to Chemotherapy Evaluated by PET/CT
The purpose of this study is to determine, whether there is clinical benefit of using fdg-PET/CT (F-18-fluorodeoxyglucose- positron emission tomography/computed tomography)compared to contrast-enhanced CT in primary treatment of…
- Conditions
- Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- Mupet (NCT01276574)
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Turku University Hospital
Systemic Sclerosis
PET Imaging of Systemic Sclerosis Using FDG and 68Ga-DOTA-Siglec-9
This study evaluates the potential of positron emission tomography (PET)/computed tomography (CT) imaging to monitor disease activity in patients with systemic sclerosis (SSc).
- Trial name
- SYSPET (NCT05108857)
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Turku University Hospital
Healthy Subjects, Rheumatoid Arthritis
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis
This study evaluates safety, tolerability, biodistribution and performance of the [68Ga]Ga-DOTA-Siglec-9 following a single intravenous administration in patients with active rheumatoid arthritis, vasculitis or pulmonary…
- Conditions
- Healthy Subjects, Rheumatoid Arthritis, Vasculitis, Pulmonary Sarcoidosis
- Trial name
- SIGLEC (NCT03755245)
- Testing
- [68Ga]Ga-DOTA-Siglec-9
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Localised Prostate Cancer, Locally Advanced Prostate Cancer
MRI Guided Transurethral HIFU for Various Prostate Diseases
This study assesses feasibility and safety, the primary outcomes, of MRI guided transurethral high intensity focused ultrasound (HIFU) ablation for prostate diseases (PD).
- Conditions
- Localised Prostate Cancer, Locally Advanced Prostate Cancer, Locally Recurrent Prostate Cancer, Benign Prostatic Hyperplasia
- Trial name
- HIFU-PRO (NCT03350529)
- Testing
- MRI guided transurethral HIFU ablation of prostatic tissue
- Where
- Finland
- Volunteers
- 87 people
- Sponsor
- Turku University Hospital
Crohn Disease, Inflammatory Bowel Diseases
Investigation of VAP-1 Expression and Tissue Blood Flow by PET-MRI in Patients With Crohn's Disease
This is an observational, single center, imaging study. The CD patients with active disease will be assessed by [68Ga]Ga-DOTA-Siglec-9 and [15O]H2O PET/MRE.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Crohn Disease of Small Intestine, Crohn Colitis
- Trial name
- VAP-PET (NCT06555042)
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Sleep Disorder, Coronary Artery Disease
Sleep Quality and Sleep-disordered Breathing in Bypass Surgery Patients
Patients undergoing non-emergency coronary artery bypass surgery (CABG) are included. All patients will be examined for transthoracic echo, blood samples will be collected, and an overnight sleep polygraph will be performed in a…
- Trial name
- UNI-CABG (NCT06453538)
- Where
- Finland
- Volunteers
- 54 people
- Sponsor
- Turku University Hospital
Kidney Diseases, Cardiovascular Diseases
Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury
CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.
- Trial name
- CADKID (NCT04223726)
- Where
- Finland
- Volunteers
- 210 people
- Sponsor
- Turku University Hospital
Exposure to Polluted Air
Neurological Symptoms and Findings in Individuals Exposed to Indoor Air Pollutants
To evaluate neurological findings with TSPO-PET and MRI in patients who have been exposed to indoor air pollutants and have potentially neurological symptoms.
- Trial name
- NCT05111678
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Pregnancy Related
Carriage of Beta Haemolytic Streptococci During Pregnancy
This is a prospective clinical study that aims to investigate asymptomatic carriage of beta haemolytic streptococci (especially group A streptococci, GAS and group B streptococci, GBS) during pregnancy.
- Trial name
- NCT05365711
- Where
- Finland
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Prostate Cancer
99mTc-MIP-1404 SPECT/CT in Primary Staging of Prostate Cancer
Prostate cancer (PCa) is currently the most common cancer in men in Finland (www.cancerregistry.fi). Although prognosis is very good in majority of men, it is noteworthy that still up to 20% of PCa cases are metastatic at the…
- Trial name
- NCT06219746
- Testing
- PSMA-imaging
- Where
- Finland
- Volunteers
- 320 people
- Sponsor
- Turku University Hospital
Uncomplicated Acute Appendicitis
Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis
APPAC IV, a randomized double-blind multicenter clinical trial comparing once daily oral moxifloxacin with placebo in an outpatient setting aims to evaluate whether antibiotics and hospitalization or both can be omitted in the…
- Trial name
- APPAC IV (NCT06210269)
- Testing
- Moxifloxacin 400mg
- Where
- 9 sites in Finland
- Volunteers
- 498 people
- Sponsor
- Turku University Hospital
Low Back Pain, Stress Fracture
Treatment of Spondylolysisin Pediatric Patients.
A clinical trial comparing healing of unilateral or bilateral spondylolysis in children treated with a Boston thoracolumbar orthosis (brace) or with a soft spinal brace (Porostrap lumbar support) for four months.
- Trial name
- NCT03675152
- Testing
- Soft spinal brace, thoracolumbar orthosis, Excersice restriction
- Where
- 2 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital