Clinical trials: sponsored by Turku University Hospital
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Variation of Genes Controlling Carbohydrate and Lipid Metabolism
Aim of the study is to investigate genes regulating glucose and lipid metabolism in subjects whose glucose metabolism, lipid metabolism, blood flow, or body fat distribution has been measured using positron emission tomography…
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Obesity, Insulin Resistance
- Trial name
- CMgene (NCT03310502)
- Where
- Finland
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Urinary Tract Stone, Kidney Stone
Magnetic Ureteral Stent Symptoms - a Comparison to Standard Ureteral Stent as Perceived By the Patient (MAGUSS)
The specific aim of this study is to validate our hypothesis that the magnetic ureteral stents have the same amount of adverse effects as the more commonly used non-magnetic ureteral stents.
- Trial name
- MAGUSS (NCT03257306)
- Testing
- ureteral double-J stent removal using magnet, ureteral double-J stent removal using cystoscopy
- Where
- 3 sites in Finland
- Volunteers
- 170 people
- Sponsor
- Turku University Hospital
Endometriosis
ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis
Endometriosis is a chronic disease characterized by the presence of functional endometrial glands and stroma in ectopic locations outside the uterine cavity.
- Trial name
- ENDOMET (NCT01301885)
- Testing
- Laparoscopy/laparotomy
- Where
- 4 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Septic Shock, Acute Kidney Injury
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Intensive care unit (ICU) mortality in patients with septic shock and acute kidney injury (AKI) requiring continuous…
- Trial name
- HEMOX-HDF (NCT04997421)
- Testing
- Combined HA380 hemoadsorption and continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes, Continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Tumor
Exercise and Tumor Blood Flow in Lymphoma And Breast Cancer Patients (EXETUMOR 3)
Recent pre-clinical studies strongly suggest that due to dysfunctional vasculature and blunted sympathetic constriction in the tumor, tumor blood flow is increased even by 200% compared to resting values.
- Trial name
- EXETUMOR3 (NCT04990856)
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 28 people
- Sponsor
- Turku University Hospital
Infant Development, Preterm Birth
Auditory Environment by Parents of Preterm Infants
Data on parent-infant physical closeness and infants' auditory environment will be collected among preterm infants when they are at gestational age of 32 to 34 weeks.
- Conditions
- Infant Development, Preterm Birth, Language Development
- Trial name
- APPLE (NCT04826978)
- Testing
- Auditory environment
- Volunteers
- 116 people
- Sponsor
- Turku University Hospital
Coronary Artery Disease, Postoperative Complications
Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery
This study evaluates the efficacy and safety of single dose preoperative ferric carboxymaltose in the prevention of postoperative infections and blood transfusions in patients scheduled for cardiac surgery.
- Conditions
- Coronary Artery Disease, Postoperative Complications, Aortic Valve Stenosis, Mitral Valve Disease
- Trial name
- PREFER-CABG (NCT03574311)
- Testing
- Ferric carboxymaltose, Physiological saline
- Where
- Finland
- Volunteers
- 210 people
- Sponsor
- Turku University Hospital
COPD
Predicting Exacerbation of COPD With Wireless Telemonitoring
This is an open-label single-center 6-month prospective clinical trial predicting exacerbation of COPD with wireless telemonitoring of respiratory rate, heart rate and sleep in patients admitted to the pulmonary ward of the Turku…
- Trial name
- NCT02791451
- Testing
- telemonitoring
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital
Head and Neck Squamous Cell Carcinoma
18F-FDG PET/CT Versus 18F-FDG PET/MRI in Detecting Locoregional Recurrence 3 Months After CRT in Head and Neck SCC
Comparing FDG PET/CT and FDG PET/MRI in the diagnostic accuracy of detecting local recurrence 12 weeks after the end of CRT in head and neck squamous cell carcinoma patients.
- Trial name
- HENEPET (NCT04196985)
- Testing
- PET/MRI, PET/CT
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Prostate Cancer
The Effect of ADT on PSMA Expression in Metastatic Prostate Cancer
Thirty-five men with newly diagnosed, metastatic prostate cancer are scanned with 18F-PSMA 1007 PET/CT at baseline, 3 weeks after the initiation of GnRH-antagonist, at one year and at the time of castration resistant prostate…
- Trial name
- ADTPSMA2 (NCT03876912)
- Testing
- GnRH antagonist
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Turku University Hospital
IBD
Combined PET-MRI in the Diagnostics of Chronic Inflammatory Bowel Diseases (IBD)- a Feasibility Study
The main purpose of the present study is to examine the diagnostic performance of combined PET-MRI in detecting colonic and small bowel wall inflammatory processes caused by ulcerative colitis and Crohn's disease.
- Trial name
- NCT02364973
- Testing
- PET-MRI
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Bladder Cancer
Electromotive Mitomycin-C (EMDA-MMC) in Preventing Recurrences in High-risk Non-muscle-invasive Bladder Cancer
Disease recurrence and progression is a major issue in high risk non-muscle-invasive bladder cancer (NMIBC). The current study compares two adjuvant instillation therapies in the treatment of high risk NMIBC.
- Trial name
- FB10 (NCT03664869)
- Testing
- BCG instillation therapy, Sequential BCG and EMDA mitomycin C
- Where
- 7 sites in Finland
- Volunteers
- 300 people
- Sponsor
- Turku University Hospital
Bone Neoplasm
Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute
This study is designed to perform a head-to-head comparison of two synthetic ceramic bone graft substitutes, bioactive glass (BAG) and beta-tricalcium phosphate (TCP), in filling of contained bone defects following surgical…
- Trial name
- BAGvsTCP (NCT00841152)
- Testing
- Bioactive glass, Beta-tricalcium phosphate (ChronOs), Autograft
- Where
- 5 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Heart Failure
Supportive Treatment of Severe Heart Failure by Renal Denervation
The overactivity of sympathetic nervous system is worsening the hemodynamic state of heart failure patients. The present study is planned to reduce the sympathetic tone in patients with severe heart failure by renal nervous…
- Trial name
- Heart-RND (NCT02638324)
- Testing
- Renal nervous denervation
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Hypertension Secondary to Renal Disease
Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy
The study is designed to investigate the efficacy of renal nerve denervation in treating drug-resistant hypertension in patients with end stage renal disease.
- Trial name
- TreatDialRDN (NCT01881035)
- Testing
- Renal nerve denervation
- Where
- Finland
- Volunteers
- 6 people
- Sponsor
- Turku University Hospital
Physical Exercise Behavior (Liking/Aversion)
Molecular and Functional Neurobiology of Physical Exercise
In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward.
- Trial name
- EXEBRAIN (NCT02615756)
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
vHIT- and VOG-model for Bilateral Vestibular Neuronitis
Ethanol-induced Vestibular Dysfunction as a Model for Bilateral Vestibular Syndrome.
The purpose of the study is to create a vHIT- and VOG-model for bilateral vestibular neuronitis, via ethanol administration in healthy human subjects.
- Trial name
- NCT04783610
- Testing
- Ethanol
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Rotating Frame Relaxation Imaging in Patients With Multiple Sclerosis
The aim of this study is to develop novel magnetic resonance imaging (MRI) protocols suitable for patients with multiple sclerosis using advanced MRI such as rotating frame relaxation imaging.
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
- Trial name
- ROMUS (NCT02403570)
- Testing
- Brain MRI
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- Turku University Hospital
Venous Reflux
EVLA and Optimal Timing of Sclerotherapy
The aim of the study is to investigate the optimal timing of sclerotherapy for treatment of varicose tributaries on EVLA (endogenous laser ablation) patients.
- Trial name
- FinnTrunk (NCT04774939)
- Testing
- Endovenous laser ablation
- Where
- Finland
- Volunteers
- 350 people
- Sponsor
- Turku University Hospital
Glymphatic System, Neurodegeneration
Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults
This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the…
- Trial name
- GLYMREG (NCT04255758)
- Testing
- Cycle Ergometer Exercise
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital