Clinical trials: sponsored by UMC Utrecht
Hypertension
The Effect of Renal Denervation on Biological Variables
Hypertension is a major and growing public health concern. Chronic elevation of sympathetic nervous system (SNS) activity has been identified as a major contributor to the complex pathophysiology of (essential) hypertension.
- Trial name
- NCT01427049
- Testing
- renal denervation
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- UMC Utrecht
Hypertension, Chronic Kidney Disease
Renal Sympathetic Denervation as a New Treatment for Therapy Resistant Hypertension
The aim of this study is to assess whether renal denervation (RD) added to usual care compared to usual care alone reduces blood pressure (BP) as determined with ambulatory BP monitoring (ABPM) after 6 months in subjects with an…
- Trial name
- SYMPATHY (NCT01850901)
- Testing
- Renal sympathetic denervation
- Where
- Netherlands
- Volunteers
- 139 people
- Sponsor
- UMC Utrecht
Heart Failure
Effectiveness of a Website and Telemonitoring in Patients With Heart Failure.
The number of people with heart failure is increasing in the western world. Mainly due to better treatment of myocardial infarctions and ageing of the population. The amount of health care workers is unfortunately not increasing.
- Trial name
- NCT01755988
- Testing
- Educational website (in addition to usual care)., Website and interactive platform with telemonitoring.
- Where
- 4 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Pregnancy Induced Hypertension
Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial
Hypertensive disorders of pregnancy (HDP) are with 50.000 deaths every year one of the major causes of maternal mortality worldwide, especially in low and middle income countries.
- Trial name
- 4P (NCT02007837)
- Testing
- Combined aspirin and multinutrient supplement, Daily text reminder text messages
- Where
- 2 sites in Ghana
- Volunteers
- 440 people
- Sponsor
- UMC Utrecht
Postpartum Hemorrhage
Active Management of the Third Stage of Labour: Uterine Tonus Assessment by Midwife vs. Patient Self-administration
To determine whether there is a difference in effectiveness of routine uterine tonus assessment (every 15 minutes, for 2 hours) when performed by a midwife or self-administered by a patient on the incidence of postpartum…
- Trial name
- UTAMP (NCT02223806)
- Testing
- Uterine Tonus Assessment by Midwife, Patient self-assessment of uterine tonus
- Where
- Ghana
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Heart; Disease, Mitral(Valve), Diseases of Mitral Valve
The Dutch Asymptomatic Mitral Regurgitation Trial
The purpose of this study is to compare early mitral valve repair versus a watchful waiting strategy in asymptomatic patients with severe organic mitral valve regurgitation and preserved left ventricular function.
- Conditions
- Heart; Disease, Mitral(Valve), Diseases of Mitral Valve, Mitral Valve Insufficiency
- Trial name
- Dutch AMR (NCT01708265)
- Testing
- Watchful waiting, Early mitral valve repair
- Where
- 4 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Bone Metastases
Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009
Cancer patients with pain due to bone metastases are often treated with external irradiation in order to reduce pain. However, patients may experience a temporary increase of pain shortly after irradiation, a so-called pain…
- Trial name
- NCT01669499
- Testing
- Dexamethasone acetate
- Where
- 2 sites in Netherlands
- Volunteers
- 411 people
- Sponsor
- UMC Utrecht
Colorectal Neoplasms, Neoplasm Metastasis
Surefire Infusion System vs. Standard Microcatheter Use During Holmium-166 Radioembolization
The objective of the SIM trial is to investigate whether using the Surefire Infusion System during holmium-166 radioembolization increases the posttreatment tumor to non-tumor activity concentration ratio, compared with using a…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Diseases, Digestive System Neoplasms
- Trial name
- SIM (NCT02208804)
- Testing
- Holmium-166-poly (L-lactic acid) microspheres
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Hallucinations, No Hallucinations
Understanding Hallucinations (Part I)
Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population.
- Trial name
- UH-1 (NCT01907568)
- Where
- 4 sites in Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Colorectal Neoplasms
EMR Versus ESD for Resection of Large Distal Non-pedunculated Colorectal Adenomas
Endoscopic resection of adenomas in the colon is the cornerstone of effective colorectal cancer prevention. Endoscopic mucosal resection (EMR) is currently the most used technique for resection of large distal colorectal…
- Trial name
- MATILDA (NCT02657044)
- Testing
- EMR, ESD
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- UMC Utrecht
Multifocal Motor Neuropathy
HyQvia in Multifocal Motor Neuropathy
Subcutaneous immunoglobulin (SCIG) and recombinant human hyaluronidase (rHuPH20) will be tested in patient witch MMN and currently under maintenance treatment with IVIG for safety, tolerability and efficacy.
- Trial name
- HYMMNE (NCT02885259)
- Testing
- rHuPH20
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Type 2 Diabetes Mellitus
Shared Decision Making Between Patients and GPs in the Treatment of Type 2 Diabetes in Primary Care.
Background: Less than 20% of type 2 diabetes mellitus (T2DM) patients in different healthcare settings achieve all treatment goals to prevent cardiometabolic disease.
- Trial name
- NCT02285881
- Testing
- Shared decision making
- Where
- Netherlands
- Volunteers
- 153 people
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick
Atrial fibrillation (AF) is the most common arrhythmia and a common cause of stroke. AF can be asymptomatic and remain undiagnosed.
- Trial name
- IDEAL-MD (NCT02270151)
- Testing
- MyDiagnostick
- Where
- Netherlands
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Atrial Fibrillation
Screening for Silent Atrial Fibrillation During Influenza Vaccination
Silent atrial fibrillation is an important cause of unnecessary strokes. If diagnosed and treated in time with anticoagulants, many disabling strokes can be prevented.
- Trial name
- NCT02006524
- Testing
- 'MyDiagnostick
- Where
- Netherlands
- Volunteers
- 3,269 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Multiple Myeloma
Revlimid, Endoxan, Prednison Evaluation After Prior Revlimid Treatment (REPEAT)
Study Phase: phase 1 and phase 2 Objective: Evaluation of the effect of lenalidomide, cyclophophamide and prednisone (REP) in patients with relapsed multiple myeloma previously treated with lenalidomide Study design: prospective…
- Trial name
- REPEAT (NCT01352338)
- Testing
- Lenalidomide, endoxan, prednisone
- Where
- 3 sites in Netherlands
- Volunteers
- 82 people
- Sponsor
- UMC Utrecht
Heart Valve Diseases, Mitral Valve Insufficiency
Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR
Surgical treatment is the only approach with potentially defined clinical success for organic mitral valve (MV) regurgitation. Recurrent or persistent complaints after initial successful MV repair is a clinical challenge in…
- Conditions
- Heart Valve Diseases, Mitral Valve Insufficiency, Heart; Dysfunction Postoperative, Cardiac Surgery, Heart; Disease, Mitral(Valve)
- Trial name
- SEP (NCT02371863)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht
Extracranial Carotid Artery Aneurysm
Carotid Aneurysm Registry
To prospectively collect data on ECAA we designed the Carotid Aneurysm Registry (CAR). The aim of this study is to collect data on ECAA and its treatment to assess the natural history of ECAA and the success and safety of…
- Trial name
- CAR (NCT02229370)
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Acute Coronary Syndrome
United Coronary Biobanks
The UNICORN consists of two collaborating biobanks, one in Utrecht and one in Singapore. From these two sites we include all patients who undergo a coronary catheterization for any reason.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction, Stable Angina
- Trial name
- UNICORN (NCT02126150)
- Where
- Singapore
- Volunteers
- 2,000 people
- Sponsor
- UMC Utrecht
Sporadic Colorectal Adenoma
Mesalazine Effects in Sporadic Colorectal Adenoma Patients
Several studies indicate that mesalazine might have a preventive effect on recurrence of adenomas in patients with and without inflammatory bowel disease.
- Trial name
- NCT01894685
- Testing
- Mesalazine
- Where
- Netherlands
- Volunteers
- 74 people
- Sponsor
- UMC Utrecht
Keratoconus
PENTACON Trial: Partial ENdothelial Trepanation in Addition to Anterior Lamellar Keratoplasty in keratoCONus
Rationale: Keratoconus is a progressive, non-inflammatory corneal disease in which irregular refractive properties of the cornea result in loss of visual acuity.
- Trial name
- PENTACON (NCT01145937)
- Testing
- PET, DALK
- Where
- 5 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- UMC Utrecht