Clinical trials: sponsored by UMC Utrecht
Infections
Effect of Antibiotic Rotation in the ICU on the Prevalence of Antibiotic Resistant Gram-negative Colonisation
The SATURN ICU-trial studies the effect of antibiotic rotation on the prevalence of antibiotic resistant Gram-negative colonisation.
- Trial name
- SATURN (NCT01293071)
- Testing
- Antibiotic rotation
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Myocardial Infarction
Biomarkers for Postoperative Myocardial Infarction in Cardiac Surgery.
Myocardial infarction and subsequent myocardial injury after cardiac surgery occurs in 7-15% of patients undergoing cardiac surgery and is associated with an increased length of stay, and reduced short- and long-term survival.
- Trial name
- NCT02569177
- Sponsor
- UMC Utrecht
Cervical Cancer
Detection of Loco-regional Invasion of Cervical Cancer With 7 Tesla MRI
Background of the study: The accurate assessment of local cervical cancer spread (i.e. invasion) is of clinical importance for staging and treatment considerations.
- Trial name
- DETECT (NCT02083848)
- Testing
- 7T MRI
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- UMC Utrecht
Liver Neoplasms
Radioactive Holmium Microspheres for the Treatment of Unresectable Liver Metastases
Radioembolisation is a known method for the treatment of liver tumors and or livermetastases. Currently small beadlets called microspheres are used that are loaded with the beta radiation emitting Yttrium-90.
- Trial name
- HEPAR-2 (NCT01612325)
- Testing
- Holmium-166 polylactic microspheres
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Atherosclerosis
Drug-eluting Balloon in Bifurcations Trial
The purpose of the DEBIUT study is to assess procedural, clinical and angiographic outcomes of: 1. Provisional T-stenting use for dilation the Paclitaxel-eluting PCI-balloon (DiorTM) in comparison to dilation with a standard…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Stable Angina, Unstable Angina
- Trial name
- DEBIUT (NCT00857441)
- Testing
- Drug eluting balloon, Liberté, PTCA balloon catheter
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Heart Failure
Strategy to Recognize and Initiate Treatment of Chronic Heart Failure
The purpose of this study is to determine whether a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized (or unestablished) heart failure in primary care will improve the functional capacity…
- Trial name
- STRETCH (NCT01202006)
- Testing
- Training of general practitioners in an uptitration protocol.
- Where
- Netherlands
- Volunteers
- 585 people
- Sponsor
- UMC Utrecht
Hypertension
The Dutch National Renal Denervation Registry
This study is a national registry of patients treated with renal denervation (RD) in the Netherlands. The aim of the study is to collect data on safety of the procedure, predictors of the blood pressure lowering effect…
- Trial name
- NL_RDN_REG (NCT02482103)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Systemic Inflammatory Response Syndrome, Myocardial Ischemia
Inflammatory Response During Anesthesia and Surgery
The purpose of this study is to investigate the effects of total intravenous anesthesia versus volatile anesthesia on the perioperative inflammatory response during and after major surgery.
- Trial name
- IRAS (NCT00356746)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Diabetes Mellitus
Effectiveness of a Computerised Prompt for Primary and Secondary Care Physicians to Refer or Refer Back Type 2 Diabetes Patients
Patients with type 2 diabetes mellitus can receive care in the general practice or at the outpatient clinic. In the region of Amersfoort in The Netherlands, primary care practices and the hospital are connected through Diamuraal…
- Trial name
- NCT02229110
- Testing
- Signal
- Where
- 2 sites in Netherlands
- Volunteers
- 2,779 people
- Sponsor
- UMC Utrecht
Transient Ischemic Attack
Markers in the Diagnosis of TIA
MIND-TIA is primarily an observational diagnostic study that aims to evaluate the role of novel biomarkers in the diagnosis of Transient Ischemic Attack (TIA)in primary care.
- Trial name
- MIND-TIA (NCT01954329)
- Where
- Netherlands
- Volunteers
- 350 people
- Sponsor
- UMC Utrecht
Atherosclerosis
Conjugated Linoleic Acid and Atherosclerosis
Rationale: Cis-9, trans-11 conjugated linoleic acid (CLA) can protect against the atherosclerosis development in several animal models.
- Trial name
- NCT00706745
- Testing
- oil rich in cis9, trans11 conjugated linoleic acid
- Where
- Netherlands
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Pneumonia
Costs, Health Status and Outcomes of CAP (Community-Acquired Pneumonia)
The purpose of this study is to collect additional data on hospitalized Community-Acquired Pneumonia (CAP) on health states, health outcomes and on (health) resources and estimate the differences in the quality of life and…
- Trial name
- CHO-CAP (NCT00812084)
- Where
- Netherlands
- Volunteers
- 48,634 people
- Sponsor
- UMC Utrecht
Hypertension
The Effect of Renal Denervation on Renal Flow in Humans
Many studies have studied the effect and safety of renal denervation. However, it remains unknown what the exact mechanism behind renal denervation is.
- Trial name
- NCT01848314
- Testing
- Renal Denervation
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Minor Intra-uterine Abnormalities
The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases
This is a comparative, controlled trial to evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.
- Trial name
- NCT00830401
- Testing
- Treatment of predefined abnormality by hysteroscopic surgery, Ofloxacinum/Doxycycline
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Hepatitis C
Rosuvastatin for Hepatitis C
Objective: Determine if maximum doses of rosuvastatin are safe in patients infected with hepatitis C and if the so called pleiotropic effects of rosuvastatin cause a decrease in the HCV viral load. Primary study parameters: 1.
- Trial name
- NCT00371579
- Testing
- rosuvastatin
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Atopic Dermatitis
Extended Release Tacrolimus (Advagraf®) in Severe Adult Atopic Dermatitis Patients
To evaluate the clinical efficacy of the extended release formulation of tacrolimus (Advagraf®) in patients with severe atopic dermatitis, who can not be treated adequately with cyclosporine A because of side effects and/or…
- Trial name
- NCT01789619
- Testing
- Extended release tacrolimus (Advagraf®)
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- UMC Utrecht
Systemic Inflammatory Response Syndrome, Cardiac Diseases
Dexamethasone for Cardiac Surgery Trial
This is a multicenter, randomized, double-blind trial, comparing clinical outcomes after the administration of high-dose dexamethasone versus placebo in patients undergoing heart surgery with the use of cardiopulmonary bypass.
- Conditions
- Systemic Inflammatory Response Syndrome, Cardiac Diseases, Postoperative Complications
- Trial name
- NCT00293592
- Testing
- Dexamethasone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
Hypotension
The Effect of Sevoflurane Versus Isoflurane on Vasopressor Need
Aim of this study is to determine the effect of isoflurane versus sevoflurane on blood pressure and systemic vascular resistance.
- Trial name
- ESIVAN (NCT00922844)
- Testing
- Sevoflurane and isoflurane
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease
Utrecht Coronary Biobank (UCORBIO)
UCORBIO enrolls patients who undergo coronary angiography (for any indication). The investigators draw blood at the moment of insertion of the procedural arterial catheter.
- Trial name
- UCORBIO (NCT02304744)
- Testing
- Observational study, no intervention.
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- UMC Utrecht