Clinical trials: sponsored by UMC Utrecht
Cardiovascular Disease, Cerebrovascular Disease
The Evening Versus Morning Polypill Utilization Study
Background and rationale: In clinical practice, antihypertensives are generally prescribed for use in the morning, whereas some statins are recommended for use in the evening.
- Conditions
- Cardiovascular Disease, Cerebrovascular Disease, Peripheral Arterial Disease
- Trial name
- TEMPUS (NCT01506505)
- Testing
- Cardiovascular Agents
- Where
- Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Acute Coronary Syndrome, Myocardial Infarction
Efficacy of Preoperative Electrocardiography
A preoperative electrocardiogram (ECG) is nearly routinely performed by anesthesiologists in elderly non-cardiac surgery patients as part of pre-anesthesia evaluation.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Cardiac Arrest
- Trial name
- NCT00928460
- Testing
- Removal of preoperative electrocardiogram
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Malignant Lymphoma, Hodgkin's Disease
Whole-body Magnetic Resonance Imaging (MRI) for Staging Malignant Lymphomas
Background: The malignant lymphomas, Hodgkin´s disease (HD) and non-Hodgkin´s lymphoma (NHL), comprise approximately 5-6% of all malignancies in adults and account for 10% of childhood cancers.
- Conditions
- Malignant Lymphoma, Hodgkin's Disease, Non-Hodgkin's Lymphoma
- Trial name
- NCT00685997
- Where
- 3 sites in Netherlands
- Volunteers
- 135 people
- Sponsor
- UMC Utrecht
Chronic Fatigue Syndrome
Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome
The aim of this study is to determine the efficacy of FITNET (web-based cognitive behavioural treatment) for adolescents with Chronic Fatigue Syndrome (CFS) in The Netherlands.
- Trial name
- FitNet (NCT00893438)
- Testing
- FitNet treatment, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Pregnancy Complications, Delivery Complications
CoPPer Study - Complications of Polycystic Ovary Syndrome (PCOS) Pregnancy: Evaluating Risk
The CoPPer study is a follow-up study of women diagnosed with Polycystic Ovary Syndrome (PCOS). Women will be included pre-conceptional and followed-up until after delivery.
- Conditions
- Pregnancy Complications, Delivery Complications, Neonatal Complications
- Trial name
- CoPPer (NCT00821379)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Peripheral Vascular Diseases, Arterial Occlusive Diseases
Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)
The purposes of this study are to determine whether intra-arterial injection of autologous stem cells is effective in the treatment of chronic limb ischemia (CLI), to characterize stem cell dysfunction in patients with CLI, and…
- Conditions
- Peripheral Vascular Diseases, Arterial Occlusive Diseases, Leg Ulcer, Gangrene
- Trial name
- JUVENTAS (NCT00371371)
- Testing
- Bone marrow punction, BM-MNC infusion
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Hospital Acquired Infections
Clinical Trial to Reduce Antibiotic Resistance in European Intensive Cares
Colonization of patients with Antimicrobial Resistant Bacteria (AMRB) like Methicillin Resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococcus (VRE) and Extended-Spectrum Beta-Lactamases (ESBL)…
- Trial name
- MOSAR-ICU (NCT00976638)
- Testing
- Chromogenic surveillance, Molecular surveillance
- Where
- 13 sites in France, Greece and 6 more
- Volunteers
- 14,318 people
- Sponsor
- UMC Utrecht
Addison's Disease
Exercise Capacity and Recovery in Addison's Disease
Exposure to stress alters the activity of the adrenomedullary, adrenocortical and sympathetic nervous system, depending on the type and intensity of the stressor.
- Trial name
- NCT01657123
- Testing
- ergometry
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Chronic Otitis Media
Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media
Chronic suppurative otitis media is one of the most common chronic infections in children worldwide. Symptoms include otorrhea, otalgia and hearing loss.
- Trial name
- NCT00189098
- Testing
- Sulfamethoxazole-trimethoprim
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- UMC Utrecht
Congenital Heart Defects, Hypoplastic Left Heart Syndrome
Cerebral Perfusion During Neonatal Cardiac Surgery
Neonates with a congenital heart defect are often in need of early cardiac surgery. In complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (DHCA).
- Conditions
- Congenital Heart Defects, Hypoplastic Left Heart Syndrome, Aortic Coarctation
- Trial name
- NCT01032876
- Testing
- Deep Hypothermic Circulatory Arrest, Antegrade Cerebral Perfusion
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- UMC Utrecht
Cardiovascular Diseases
Internet Based Vascular Risk Factor Intervention and Self Management Study
The objective of the study is to evaluate the efficacy and cost-effectiveness of an internet based vascular risk factor program on top of usual care compared to usual care alone for treatment of vascular risk factors in patients…
- Trial name
- IRIS (NCT00785031)
- Testing
- internet based vascular risk factor intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- UMC Utrecht
Acute Stroke
The Dutch Acute Stroke Trial (DUST): Prediction of Outcome With Computed Tomography (CT) - Perfusion and CT-angiography
Less than 10% of all ischemic stroke patients are treated by intravenous thrombolysis (IVT) as most present later than the accepted 3 hour time window.
- Trial name
- DUST (NCT00880113)
- Testing
- Non-contrast CT, CT-perfusion and CT-angiography
- Where
- 14 sites in Netherlands
- Volunteers
- 1,500 people
- Sponsor
- UMC Utrecht
Healthy
The Lifestyle moDIfCation Study
Rationale: Lifestyle modifications, such as increasing physical exercise and reducing dietary salt and saturated fat intake contribute to prevention of cardiovascular morbidity and mortality.
- Trial name
- LUDIC (NCT01574040)
- Testing
- Promotion of stair climbing, Promotion of a low-salt soup alternative for the 'soup of the day', Promotion of a low-fat alternative for the butter croissants
- Where
- Netherlands
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Fetal Hypoxia, Reperfusion Injury
Antenatal Allopurinol During Fetal Hypoxia
A former study (submitted) in 32 severely asphyxiated infants participating in a randomized double blind study, in which early postnatal allopurinol or a placebo (within 4 hours after birth) was administered to reduce free…
- Trial name
- NCT00189007
- Testing
- Allopurinol sodium, Mannitol
- Where
- 11 sites in Netherlands
- Volunteers
- 222 people
- Sponsor
- UMC Utrecht
Carotid Artery Stenosis, Ischemic Stroke
Platelet Reactivity and MES During CEA
The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).
- Conditions
- Carotid Artery Stenosis, Ischemic Stroke, Myocardial Infarction, Aspirin Resistance
- Trial name
- NCT01547039
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Hypertension, Abdominal Obesity
Treatment of Adiposity Related hypErTension (TARGET)
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke. High blood pressure often occurs in people who are overweight. These people frequently also have abnormal fat and sugar metabolism.
- Conditions
- Hypertension, Abdominal Obesity, Metabolic Syndrome
- Trial name
- TARGET (NCT01138423)
- Testing
- Aliskiren, Moxonidine, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Cervix Neoplasms, Ovarian Neoplasms
Diagnostic Imaging of Lymph Nodes in Gynaecologic Oncology
The purpose of the study is to determine the diagnostic accuracy of a new magnetic resonance imaging (MRI) technique, the diffusion weighted imaging with body background signal suppression (DWIBS) in the detection of lymph node…
- Conditions
- Cervix Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Vulvar Neoplasms
- Trial name
- NCT00288821
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- UMC Utrecht
Liver Metastasis, Liver Tumors
Radioactive Holmium Microspheres for the Treatment of Liver Metastases
The HEPAR study is aimed at determining the safety of radioactive holmium containing microspheres for the treatment of tumors in the liver.
- Trial name
- HEPAR (NCT01031784)
- Testing
- holmium-166 poly lactic acid microspheres, holmium 166 microspheres
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Breast Cancer
"The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Rationale: Approximately 25% of breast cancers detected are non palpable. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer.
- Trial name
- ROLL (NCT00539474)
- Testing
- Radio guided occult lesion localisation
- Where
- 4 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- UMC Utrecht
Heart Failure, Congestive, Renal Insufficiency, Chronic
Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome
Erythropoietin (EPO) treatment in patients with the severe cardiorenal syndrome increases cardiac performance and decreases progression of renal failure by dampening the main driving forces of the cardiorenal syndrome in part via…
- Trial name
- NCT00356733
- Testing
- Erythropoietin administration
- Where
- 2 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- UMC Utrecht