Clinical trials: sponsored by UMC Utrecht
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage:a Feasibility Study
The purpose of this study is to test the feasibility of a trial on induced hypertension to improve neurological outcome in patients with subarachnoid haemorrhage that developed the serious complication "delayed cerebral…
- Trial name
- NCT00841633
- Testing
- Induced hypertension with norepinephrine
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Streptococcus Pneumoniae Infection
Effect of Two Versus Three Pneumococcal Conjugate Vaccinations
Two( 2) or three (3) instead of four vaccinations before the age of 6 months with pneumococcal conjugate vaccine are presumed to protect children against invasive pneumococcal disease like meningitis, at least on the short term…
- Trial name
- MNOES (NCT00189020)
- Testing
- PCV7
- Volunteers
- 1,005 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Tinnitus
Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus
Tinnitus is a phantom auditory perception of meaningless sound, meaning that there is registration of sound in the absence of an external or internal acoustic stimulus.
- Trial name
- NCT00668720
- Testing
- transcranial magnetic stimulation (Magstim rapid2)
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- UMC Utrecht
Alveolar Hypoventilation Resulting in Hypoxemia
Capnography During Nurse Administered Propofol Sedation
Rationale: The current standard of respiratory monitoring for patients during deep sedation is continuous pulse oximetry with visual assessment of the patient.
- Trial name
- NCT01220765
- Testing
- Capnography
- Where
- Netherlands
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Haemophilia, Cardiovascular Disease
Cardiovascular Disease (CVD) in Haemophilia
Life expectancy of hemophilia patients has improved considerably during the past decades and is approaching that of the general population.
- Trial name
- NCT01303900
- Where
- 6 sites in Netherlands, United Kingdom
- Volunteers
- 750 people
- Sponsor
- UMC Utrecht
Chronic Obstructive Pulmonary Disease
Action Plan to Enhance Self-management and Early Detection of Exacerbations in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this randomized controlled trial is to evaluate the hypothesis that the 'written' action plan, a self-management tool developed by the project group, enhances early detection and prompt action measures and…
- Trial name
- ACZiE (NCT00879281)
- Testing
- Action plan
- Where
- Netherlands
- Volunteers
- 233 people
- Sponsor
- UMC Utrecht
Stable Chronic Kidney Disease, Hypertension
Atorvastatin and Sympathetic Activity in Chronic Kidney Disease
Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity which appears to contribute to the pathogenesis of hypertension and cardiovascular organ damage.
- Trial name
- NCT01257009
- Testing
- Atorvastatin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Adolescent Psychiatry, Antisocial Personality Disorders
Impaired Decision-making in Adolescents
There is clear evidence that aggressive behavior and disruptive behavior disorders (DBD) in middle childhood are associated with an increased risk for substance abuse in adolescence.
- Conditions
- Adolescent Psychiatry, Antisocial Personality Disorders, Substance-Related Disorders
- Trial name
- NCT01253993
- Where
- Netherlands
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Delirium
Rivastigmine for Intensive Care Unit (ICU) Delirium
Delirium in Intensive Care (IC) patients is a frequent disorder. The aim of this study is to investigate whether treatment of delirium in the ICU with rivastigmine added to haloperidol shortens the duration of delirium in…
- Trial name
- NCT00704301
- Testing
- Rivastigmine
- Where
- 6 sites in Netherlands
- Volunteers
- 104 people
- Sponsor
- UMC Utrecht
Metabolic Syndrome
Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function
In the present study the investigators are researching the effects of the cholesterol absorption inhibitor ezetimibe on postprandial lipemia and postprandial endothelial function in patients with the metabolic syndrome.
- Trial name
- NCT00189085
- Testing
- simvastatin and ezetimibe
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Chronic Kidney Disease, Hypertension
Aliskiren and Muscle Sympathetic Nerve Activity
The central hypothesis of this project is that Aliskiren causes a substantial decrease in MSNA in hypertensive patients with CKD.
- Conditions
- Chronic Kidney Disease, Hypertension, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT00719316)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Child Abuse
Effect E-learning Program About Child Maltreatment
The purpose of this study is to determine whether the e-learning program about the recognition of child maltreatment is effective in nurses on the A\&E department compared to a control group.
- Trial name
- NCT00844571
- Testing
- E-learning program
- Volunteers
- 38 people
- Sponsor
- UMC Utrecht
Infertility
Incidence of Early Pregnancy Loss in Patients With Unexplained Infertility
Unexplained fertility could be partly caused by a higher incidence of early pregnancy loss in this group. 65 women with unexplained infertility and 65 healthy controls will collect daily urine samples form the luteal phase.
- Trial name
- UNEXPLAINED (NCT01015690)
- Where
- Netherlands
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Coronary Artery Disease
Long-term Comparison of Stenting Versus Off-pump Coronary Bypass Surgery
The randomized comparison of two strategies in coronary revascularization: bypass surgery without the use of a heart lung machine and coronary stenting procedure.
- Trial name
- OCTOSTENT (NCT00975858)
- Testing
- Coronary Revascularization
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht
Schizophrenia, Schizophreniform Disorders
Functional Brain Activation Patterns in Schizophrenia, Measured Before and After Treatment
In this study we, the investigators at UMC Utrecht, intend to investigate changes in brain activation patterns using functional magnetic resonance imaging (MRI), in patients suffering from schizophrenia who are medication naive…
- Trial name
- NCT00161057
- Where
- Netherlands
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Reward, Tetrahydrocannabinol
Investigating the Acute Effects of THC on Functional Brain Systems
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
- Conditions
- Reward, Tetrahydrocannabinol, Endocannabinoids, Memory
- Trial name
- FIX (NCT00628706)
- Testing
- Delta9-tetrahydrocannabinol (THC)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Hepatitis C, HIV Infections
Peginterferon and Ribavirin on Virologic and Immunologic Parameters in Hepatitis C Mono- and Coinfected Patient (PRIVICOP)
Hepatitis C and HIV infect worldwide millions of people leading to a high rate of coinfected patient with eventually liver cirrhosis and endstage liver disease.
- Trial name
- NCT00150904
- Testing
- venous blood puncture
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- UMC Utrecht
Hepatitis C, Weight Loss
Nutritional Support During Antiviral Therapy for Hepatitis C
Standard antiviral treatment consists of weekly injections with Peginterferon-α in combination with ribavirin. This treatment may lead to significant weight loss (7% within 24 weeks on average), with decreased quality of life.
- Trial name
- NCT00841243
- Testing
- Nutrison (Nutricia)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Postoperative Nausea and Vomiting
Implementation Study of the PostOperative Nausea and Vomiting Prediction Rule
This study evaluates whether the implementation of a prediction rule for postoperative nausea and vomiting changes physician behaviour, improves patient outcome and improves cost-effectiveness of treatment of postoperative nausea…
- Trial name
- NCT00293618
- Testing
- Automatic Risk Presentation in the operating room, Education, Feedback
- Where
- Netherlands
- Volunteers
- 11,970 people
- Sponsor
- UMC Utrecht
Abdominal Aortic Aneurysm
Vasovist Endoleak Study
After endovascular treatment of an abdominal aortic aneurysm, lifelong imaging follow-up is needed to monitor the effectiveness of the treatment.
- Trial name
- NCT00483665
- Testing
- Computed tomography angiography, Magnetic resonance imaging
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht