Clinical trials: sponsored by UMC Utrecht
Pain
Augmented Cerebral Pain Processing in Chronic, Unexplained Pain: a fMRI Study
Chronic, unexplained pain symptoms are very common in all layers of the population, but it is largely unknown what causes them. This study examines the hypothesis that patients with these pain symptoms process pain abnormally in…
- Trial name
- NCT00463177
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- UMC Utrecht
Arrhythmia, Heart Diseases
Cost-Effectiveness of Routine Follow-up Visits in Patients With a Pacemaker: The Followpace Study
The overall objective of the study is to quantify the true prognostic value and cost-effectiveness of routine follow-up visits in patients who receive an approved pacemaker of any type for the first time.
- Trial name
- NCT00135174
- Where
- Netherlands
- Volunteers
- 1,526 people
- Sponsor
- UMC Utrecht
Healthy
The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children
Background of the study: Results from several studies show that vitamin K has an important function in bone metabolism. In a previous cross-sectional study conducted by our department, evidence for a poor vitamin K status of bone…
- Trial name
- NCT00402974
- Testing
- menaquinone 7
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Breast Neoplasms
The MONET - Study: MR Mammography of Nonpalpable Breast Tumors
The purpose of this study is to determine whether performing MRI of the breast will improve breast cancer management by reducing the number of biopsies and in case of malignancy allowing one-stage surgical excision of the tumor.
- Trial name
- MONET (NCT00302120)
- Testing
- Contrast-enhanced MR mammography
- Where
- 3 sites in Netherlands
- Volunteers
- 440 people
- Sponsor
- UMC Utrecht
Abdominal Aortic Aneurysm
Dutch Randomised Endovascular Aneurysm Management (DREAM-) Trial
The purpose of this trial is to assess whether the new endovascular repair technique of the abdominal aortic aneurysm (AAA) is an adequate substitute of the conventional AAA repair.
- Trial name
- NCT00421330
- Testing
- Open Aneurysm Repair, Endovascular Aneurysm Repair
- Volunteers
- 392 people
- Sponsor
- UMC Utrecht
Infertility
Implantation and Cytokine Expression
Implantation failure of the embryo might be the result from the environment in the uterus. Proteins (cytokines) are screted by the endometrium which can result in a pro or anti inflammatory environment.
- Trial name
- NCT00264992
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Infertility
Failure of Implantation After Recurrent Embryo Transfers
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment.
- Trial name
- NCT00351481
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Fetal Growth Retardation
Antenatal Allopurinol in Intrauterine Growth Restriction
Growth retardation in utero may be caused by uteroplacental vascular insufficiency. When Doppler ultrasound studies of the umbilical artery are abnormal pathological intrauterine growth restriction (IUGR) can be diagnosed.
- Trial name
- NCT00346463
- Testing
- Allopurinol
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Glioma, Cognition Disorders
Cognitive Rehabilitation of Glioma Patients
The purpose of this study is to determine whether cognitive rehabilitation is effective in patients with gliomas (brain tumour), by comparing direct and follow-up neuropsychological functioning and quality of life of the…
- Trial name
- NCT00256425
- Testing
- Cognitive rehabilitation
- Where
- 9 sites in Netherlands
- Volunteers
- 140 people
- Sponsor
- UMC Utrecht
Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
Prevention of Respiratory Infections and MAnagement Among Children (PRIMAKid)
The PRIMAKid trial is a general practice based double-blind randomized placebo-controlled trial on the effectiveness and costs of combined influenza and pneumococcal vaccination in pre-school children with recurrent respiratory…
- Trial name
- NCT00161122
- Testing
- trivalent inactivated influenza vaccine, combined heptavalent pneumococcal conjugate vaccine and trivalent inactivated influenza vaccine
- Where
- Netherlands
- Volunteers
- 660 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Cardiopulmonary Bypass
Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Coronary artery bypass surgery is associated with postoperative cognitive decline, which has largely been attributed to the use of the heart lung machine.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Cognition Disorders
- Trial name
- NCT00189215
- Testing
- cardiac stabilizer instead of cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht
Oppositional Defiant Disorder, Conduct Disorder
Prevention of Oppositional Defiant and Conduct Disorders in Preschool Children
Oppositional defiant and conduct disorders are the most frequent bases for referral of children and adolescents. These disorders are difficult to treat among school-aged children and adolescents.
- Trial name
- NCT00189189
- Testing
- parent management training
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Amyotrophic Lateral Sclerosis
Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis
The purpose of this study is to determine whether the use of sodium valproate is effective in slowing the disease progression in Amyotrophic Lateral Sclerosis.
- Trial name
- NCT00136110
- Testing
- Sodium Valproate
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- UMC Utrecht
Autism
Functional MRI of Cognitive Control in Autism
This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism.
- Trial name
- NCT00463164
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Psychotic Disorders
Dutch Prediction of Psychosis Study
The Dutch Prediction of Psychosis Study (DUPS) is a prospective study of predictors of the transition to psychosis in help-seeking adolescents at high risk for developing a first psychotic episode.
- Trial name
- NCT00188981
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Colonic Diseases, Functional
Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or no Fibre?
The purpose of this study is to assess the role of dietary fibre in Irritable Bowel Syndrome (IBS) treatment, in particular the role of increasing the content of soluble or insoluble fibres in the daily diet.
- Trial name
- NCT00189033
- Testing
- psyllium fibre (dietary supplement), wheat bran (dietary supplement)
- Where
- 2 sites in Netherlands
- Volunteers
- 285 people
- Sponsor
- UMC Utrecht
Autism, Developmental Disabilities
Magnetic Resonance Imaging in Children and Adolescents With Autism and Multiple Complex Developmental Disorders
This study aims to investigate the overlap and differences between autism and MCDD as neuropsychiatric childhood disorders. MRI scans are acquired from subjects with autism, subjects with a diagnosis of MCDD and typically…
- Trial name
- NCT00161135
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Rheumatoid Arthritis
Effects of Home-Based Emotional Disclosure in Rheumatoid Arthritis
The purpose of the study is threefold: 1) to develop a home-based emotional disclosure intervention inducing core elements of change (emotional engagement, cognitive restructuring, and positive future directedness); 2) to examine…
- Trial name
- NCT00462150
- Testing
- home-based emotional disclosure, time management control condition
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Brain Ischemia, Transient Ischemic Attack
ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial
The objective of ESPRIT was to compare the efficacy and safety of mild anticoagulation or a combination treatment of aspirin and dipyridamole with the efficacy and safety of treatment with aspirin alone after cerebral ischemia of…
- Conditions
- Brain Ischemia, Transient Ischemic Attack, Arteriosclerosis
- Trial name
- NCT00161070
- Testing
- anticoagulation, aspirin and dipyridamole, aspirin alone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
Autism
Magnetic Resonance Imaging of Brain Development in Autism
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques.
- Trial name
- NCT00449566
- Where
- Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht