Clinical trials: sponsored by UMC Utrecht
Ischemic Stroke
Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke
Rationale: Over 20.000 people suffer an ischemic stroke in the Netherlands each year. Large artery occlusions are easy to identify and can be treated with endovascular clot removal.
- Trial name
- ENCLOSE (NCT04019483)
- Where
- 3 sites in Netherlands
- Volunteers
- 439 people
- Sponsor
- UMC Utrecht
Perinatal Arterial Ischemic Stroke, Neonatal Stroke
Perinatal Arterial Stroke Treated With Stromal Cells Intranasally
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, administered by the nasal route, in neonates who suffered from PAIS.
- Trial name
- PASSIoN (NCT03356821)
- Testing
- Mesenchymal Stem Cells
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Depressive Disorder
Prediction of ECT Treatment Response and Reduction of Cognitive Side-effects Using EEG and Rivastigmine
The goal of this clinical trial is to test the beneficial effects of rivastigmine administration, and predict the treatment outcome with electroencephalography (EEG), in patients with severe depression treated with…
- Trial name
- PRECISER (NCT05768126)
- Testing
- Rivastigmine Transdermal Product
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Respiratory Tract Infections, Coinfection
Virus Interactions in the Respiratory Tract; a Cohort Study With Children
Rationale: Prevention of virus induced acute respiratory infection (ARI) is a public health priority. As different respiratory virus infections can interact with each other, occurrence of one virus may influence occurrence of…
- Trial name
- VIOOL (NCT05318235)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Sarcopenia, Frailty
Implementation of ProMuscle in Daily Practice
Implementation of a previously shown (cost-)effective combined lifestyle intervention for community living older adults, ProMuscle, in at least four of the eight communities of the 'Foodvalley' in the Netherlands.
- Conditions
- Sarcopenia, Frailty, Aging Problems
- Trial name
- PUMP-fit (NCT05672004)
- Testing
- PUMP-fit strategy (implementation toolbox), Implementation as usual
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Hypoperfusion in Newborn With Congenital Heart Disease
Cerebral Blood Flow in Neonates During Major Cardiac Surgery.
Rationale: During cardiac surgery, neonates are at high risk of cerebral damage: 36-78% will have new cerebral lesions after surgery.
- Trial name
- FLOWER (NCT04713605)
- Testing
- Critical closing pressure detection
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
RSV Infection
Respiratory Syncytial Virus (RSV) Burden in Older Adults in Primary Care in The Netherlands
RSV infection is a leading cause of medical care in older adults, sometimes leading to hospital admission and severe outcomes. Although the majority of RSV infections are managed outside hospitals, little is known on the burden…
- Trial name
- RAPID (NCT06318936)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Glanzmann Thrombasthenia
Multinational Glanzmann Study
Glanzmann thrombasthenia is a rare autosomal recessive platelet disorder characterized by a lack of functional integrins alfaIIb or beta3 (glycoproteins IIb/IIIa).
- Trial name
- Glanzmann-NHS (NCT06204042)
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease, Atrial Fibrillation
Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project
The goal of this randomized trial is to compare the diagnostic yield of a screen-like early diagnosis strategy to usual primary care to detect coronary artery disease (CAD), atrial fibrillation (AF), heart failure (HF), and/or…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Heart Failure, Valvular Heart Disease
- Trial name
- RED-LRGP (NCT05775354)
- Testing
- Early diagnosis strategy
- Where
- Netherlands
- Volunteers
- 1,476 people
- Sponsor
- UMC Utrecht
Locally Advanced Pancreatic Adenocarcinoma
Locally Advanced Pancreatic Cancer After Systemic Therapy: Ablative MR-guided Radiotherapy
A randomized controlled trial comparing the effect of local ablative MR-guided radiotherapy (MRgRT) after systemic therapy with current standard treatment alone, on health-related quality of life in patients with locally advanced…
- Trial name
- LAPSTAR (NCT06272162)
- Testing
- MR guided radiotherapy
- Where
- 4 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Pulmonary Embolism, Ventilation Perfusion Mismatch
68Ga PET/CT Versus 99mTc SPECT/CT for Lung Perfusion and Ventilation Scintigraphy; a Technical and Practical Feasibility Study
Lung perfusion scintigraphy with 99mTc-MAA and ventilation scintigraphy with Technegas (V/Q SPECT/CT) has been the cornerstone for the detection of pulmonary embolisms (PE) for many decades.
- Trial name
- GaTcha (NCT06246838)
- Testing
- Ga-68 V/Q PET/CT
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Bone Metastases, Bone Neoplasm
Feasibility of Combined Focused Ultrasound and Radiotherapy Treatment in Patients With Painful Bone Metastasis
The PRE-FURTHER study aims to evaluate the feasibility of the combined treatment with radiotherapy and focussed ultrasound for pain palliation in patients with painful bone metastases, and to optimize the combined treatment…
- Conditions
- Bone Metastases, Bone Neoplasm, Bone Lesion, Bone Cancer
- Trial name
- PRE-FURTHER (NCT04310410)
- Testing
- combined radiotherapy and MR-HIFU
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Lung Cancer
Utrecht COhort for Lung Cancer Outcome Reporting and Trial Inclusion (U-COLOR)
Objective: 1) To collect information on patient characteristics, short- and long-term clinical and patient-reported outcomes; and 2) to create an infrastructure for efficient, fast, and pragmatic randomized evaluation of new…
- Trial name
- U-COLOR (NCT05069792)
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- UMC Utrecht
Spinal Metastases, Bone Metastases
Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study
The purpose of the study is to investigate effectiveness of stereotactic body radiotherapy in patients with bone metastatic disease.
- Trial name
- VERTICAL (NCT02364115)
- Testing
- Stereotactic Body Radiotherapy
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- UMC Utrecht
Breast Cancer
Utrecht Cohort for Multiple Breast Cancer Intervention Studies and Long-term Evaluation - The UMBRELLA Cohort
Due to better treatment options and earlier detection, survival rates of patients with breast cancer continue to increase. As such, (late) treatment toxicity, (long-term) quality of life and the cosmetic outcome are becoming more…
- Trial name
- UMBRELLA (NCT02839863)
- Where
- 4 sites in Netherlands
- Volunteers
- 10,000 people
- Sponsor
- UMC Utrecht
Breast Cancer, Cardiovascular Diseases
Automated Quantification of Coronary Artery Calcifications on Radiotherapy Planning CTs for Cardiovascular Risk Prediction in Breast Cancer Patients: the BRAGATSTON Study
The aim of the BRAGATSTON study is to provide a low cost tool for measuring CAC in breast cancer patients, thereby identifying patients at increased risk of CVD.
- Trial name
- NCT03206333
- Where
- 3 sites in Netherlands
- Volunteers
- 16,000 people
- Sponsor
- UMC Utrecht
Fluorodeoxyglucose F18, Phosphoric Monoester Hydrolases
Deuterium Metabolic MRI and [18F]FDG PET for Assessment of Treatment Response Following Radioembolization
Radioembolization, also known as Selective Internal Radiation Therapy (SIRT), is a liver-directed therapy for patients suffering from hepatic metastases.
- Conditions
- Fluorodeoxyglucose F18, Phosphoric Monoester Hydrolases, Phosphoric Diester Hydrolases
- Trial name
- DEPLETE (NCT06232889)
- Testing
- Deuterium Glucose Metabolic Imaging with MRI spectroscopy
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Prostate Cancer
PSMA Response in Metastasized Hormone Sensitive Prostate Cancer - Enzalutamide
PSMA-PET/CT response measurements after LHRH agonist and upfront enzalutamide therapy in men diagnosed with de novo metastasized hormonal sensitive prostate cancer.
- Trial name
- PET-MaN-enza (NCT05539300)
- Testing
- PSMA-PET/CT response evaluation
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Extracorporeal Membrane Oxygenation, Extracorporeal Membrane Oxygenation Complication
PREdiCtIon of Weanability, Survival and Functional outcomEs After ECLS
Extracorporeal life support (ECLS) is used as a last resort intervention in patients with severe cardiac, circulatory and/or respiratory failure with high (>80%) expected mortality.
- Trial name
- PRECISE - ECLS (NCT05444764)
- Where
- 6 sites in Netherlands
- Volunteers
- 800 people
- Sponsor
- UMC Utrecht
Breast Cancer
Liquid Biopsies and Imaging in Breast Cancer
The aim of the study is to show proof of concept for combining multi-parametric MRI with liquid biopsies in addition to conventional clinical and pathologic information, to accurately predict response to neoadjuvant treatment for…
- Trial name
- LIMA (NCT04223492)
- Testing
- Liquid biopsy, Multi-parametric MRI
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- UMC Utrecht