Clinical trials: sponsored by UMC Utrecht
Diabetes Mellitus, Type 2, Diet, Vegetarian
The Effect of an Online Plant-Based Dietary Program on Cardiovascular Risk Factors in Persons With Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Persons with Type 2 Diabetes (T2D) are at an increased risk of cardiovascular disease (CVD) and mortality. Dietary changes are recommended by guidelines to treat T2D and reduce risk of CVD.
- Conditions
- Diabetes Mellitus, Type 2, Diet, Vegetarian, Diet, Vegan, Cardiometabolic Risk Factors
- Trial name
- Plate-DM (NCT05777746)
- Testing
- 12-week plant-based dietary program, Usual Diet
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- UMC Utrecht
Periprosthetic Joint Infection, PJI
Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID
The primary objective of this study is to demonstrate the validity of the Microbial- ID test to aid in diagnosis of periprosthetic joint infection (PJI) in terms of sensitivity and specificity.
- Trial name
- MID (NCT05320354)
- Testing
- Microbial ID test
- Where
- 6 sites in Germany, Netherlands and 4 more
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Primary Antibody Deficiencies
Early Detection of Primary Antibody Deficiencies in Primary Care Facilities by an Algorithm Driven Selection of Serologic Testing in Individuals at Risk.
Rationale: Primary antibody deficiencies (PAD) encompass a group of rare heterogeneous diseases. The clinical presentation may vary widely, including infectious and autoimmune symptoms and increased risk of malignancy.
- Trial name
- GP-PAD II (NCT05310604)
- Testing
- Blood withdrawal
- Where
- Netherlands
- Volunteers
- 104 people
- Sponsor
- UMC Utrecht
Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
Pancreatic Cancer Recurrence in the Netherlands
The aim of this nationwide, observational cohort study is to evaluate current surveillance strategies after primary resection of pancreatic ductal adenocarcinoma (PDAC) in the Netherlands, with regard to the detection, treatment…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer, Pancreas Cancer, PDAC
- Trial name
- NCT04605237
- Where
- Netherlands
- Volunteers
- 1,750 people
- Sponsor
- UMC Utrecht
Heart Failure
REsponsible roLl-out of E-heAlth Through Systematic Evaluation - Heart Failure Study
Telemedicine is gradually becoming accepted in heart failure (HF) management. Meta-analyses show a positive effect of telemedicine on hospital admission, length of stay, mortality, and costs.
- Trial name
- RELEASE-HF (NCT05654961)
- Testing
- Use of telemedicine
- Where
- 34 sites in Netherlands
- Volunteers
- 6,480 people
- Sponsor
- UMC Utrecht
Spinal Muscular Atrophy
Respiratory Muscle Training in Patients With Spinal Muscular Atrophy (SMA).
The goal of this clinical trial is to study respiratory muscle training in patients with Spinal Muscular Atrophy (SMA). The main questions it aims to answer are: Is a home-based individualized training program for the inspiratory…
- Trial name
- RESISTANT (NCT05632666)
- Testing
- Inspiratory and expiratory muscle training at a therapeutic intensity, Inspiratory and expiratory muscle training at a non-therapeutic intensity
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Fuchs Dystrophy, Endothelial Corneal Dystrophy
The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation
Rationale: Intra-operative optical coherence tomography (iOCT) is a new technology that incorporates advanced imaging techniques in the ophthalmic operating theatre.
- Conditions
- Fuchs Dystrophy, Endothelial Corneal Dystrophy, Bullous Keratopathy, Vision Disorders
- Trial name
- ADVISE (NCT03763721)
- Testing
- intraoperative optical coherence tomography (iOCT)
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 65 people
- Sponsor
- UMC Utrecht
Hepatocellular Carcinoma Non-resectable
Individualized Dosimetry for Holmium-166-radioembolization in Patients With Unresectable Hepatocellular Carcinoma
Patients with hepatocellular carcinoma often die from intrahepatic disease because current treatment options are limited. Local treatment using 166Ho-radioembolization (166Ho-RE) offers a safe and effective treatment.
- Trial name
- iHEPAR (NCT05114148)
- Testing
- Holmium-166 radioembolization
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Hepatocellular Carcinoma, Hepatocellular Carcinoma Non-resectable
HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients
Patients with hepatocellular carcinoma often die from intrahepatic disease since current treatment options are generally limited.
- Trial name
- NCT03379844
- Testing
- Holmium-166 radioembolization
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Fetal Growth Retardation
OPtimal TIming of COrticosteroids in Early-onset Fetal Growth REstriction: the OPTICORE Study
The aim of this observational study is to optimize the timing of antenatal corticosteroids administered to patients with pregnancies complicated by early-onset fetal growth restriction in order to reduce neonatal morbidity and…
- Trial name
- OPTICORE (NCT05606497)
- Testing
- Corticosteroid
- Where
- Netherlands
- Volunteers
- 1,800 people
- Sponsor
- UMC Utrecht
Respiratory Tract Infections, Covid19
Prevention Of Respiratory Tract Infection And Covid-19 Through BCG Vaccination In Vulnerable Older Adults
On March 11 2020 the World Health Organization (WHO) declared the coronavirus (SARS-CoV-2) outbreak a pandemic. Worldwide, the number of confirmed cases continues to rise, leading to significant morbidity and mortality.
- Trial name
- BCG-PRIME (NCT04537663)
- Testing
- Bacille Calmette-Guérin (BCG)
- Where
- 20 sites in Netherlands
- Volunteers
- 6,112 people
- Sponsor
- UMC Utrecht
Brain Metastases, Adult, Brain Neoplasms, Adult, Malignant
The Cohort for Patient-reported Outcomes, Imaging and Trial Inclusion in Metastatic BRAin Disease (COIMBRA)
The incidence of brain metastases is expected to increase because of better treatments of primary tumours. Novel diagnostic and therapeutic techniques are continuously being developed, all of which need thorough evaluation before…
- Trial name
- COIMBRA (NCT05267158)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease (CAD), Coronary Artery Calcification
Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Calcification, Occupational Diseases, Aviator's; Disease
- Trial name
- SUSPECT (NCT05508893)
- Testing
- CT Angiography, Exercise stress test
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Delirium
Clinical Evaluation Program of DeltaScan (ICU)
Rationale: Delirium, or acute brain failure, presents as an acute confusional state, and is associated with prolonged hospitalization, an increased risk of dementia, institutionalization and mortality, as well as increased costs.
- Trial name
- NCT03735940
- Where
- Netherlands
- Volunteers
- 3,630 people
- Sponsor
- UMC Utrecht
Food Allergy
Effectiveness of Dupilumab in Food Allergic Patients With Moderate to Severe Atopic Dermatitis
This study evaluates the effectiveness of Dupilumab in food allergic patients with moderate to severe Atopic Dermatitis (AD). Included patients participated in the BioDay Registry.
- Trial name
- NCT04462055
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- UMC Utrecht
SARS-CoV-2
Within Household Transmission of COVID-19 Infections
In the absence of a vaccine, the spread of SARS-CoV-2 can only be mitigated via non-pharmaceutical interventions that reduce the risks of forward transmission.
- Trial name
- VERDI (NCT05430516)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Delirium
Clinical Evaluation Program of DeltaScan (Ward)
Rationale: Delirium, or acute brain failure, presents as an acute confusional state, and is associated with prolonged hospitalization, an increased risk of dementia, institutionalization and mortality, as well as increased costs.
- Trial name
- NCT03735927
- Where
- Netherlands
- Volunteers
- 3,907 people
- Sponsor
- UMC Utrecht
COVID-19
Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine
Rationale: Covid-19 spreads rapidly throughout the world. A large epidemic in the Netherlands would seriously challenge the available hospital capacity, and this would be augmented by absenteeism of healthcare workers (HCW).
- Trial name
- BCG-CORONA (NCT04328441)
- Testing
- BCG Vaccine
- Where
- 9 sites in Netherlands
- Volunteers
- 1,511 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Systemic Lupus Erythematosus
PRediction Of Flares In Lupus With autoantibodiEs and Chemokines
Rationale: Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease with a wide range of clinical manifestations affecting several organs.
- Trial name
- PROFILE (NCT04951427)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Patients Suspected for a Pancreatic (Pre-)Malignancy
Quality of Life After Surgery for Pancreatic Carcinoma
Pancreatic cancer has a high mortality rate. Patients with an intended curative resection show a median survival of 17-23 months. Therefore, quality of life is very important in this patient group.
- Trial name
- NCT02175992
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht