Clinical trials: completed, sponsored by UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Lapatinib and Radiation Therapy in Treating Patients With Locally Recurrent or Chemotherapy-Refractory Locally Advanced or Metastatic Breast Cancer
RATIONALE: Lapatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00379509
- Testing
- lapatinib ditosylate, TdT-mediated dUTP nick end labeling assay, gene expression analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Kidney Cancer
Open-label Pilot Evaluating Renal Lesions w/ Contrast-enhaced US in Patients w/ Renal Cancer
This prospective pilot study is designed to evaluate the accuracy of contrast-enhanced ultrasound when used to evaluate renal lesions in two different populations; patients with known renal tumors (Cohort 1) and patients with a…
- Trial name
- NCT01751529
- Testing
- Contrast-enhanced Ultrasound, Perflutren lipid
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Major Depressive Disorder, Neoplasms
Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancer
This is a pilot study to test the hypothesis that the antidepressants mirtazapine and citalopram are effective treatment for major depressive disorder (MDD) in cancer patients.
- Trial name
- NRR (NCT01725048)
- Testing
- Mirtazapine, Citalopram
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lung Cancer
Pazopanib In Stage IIIB/IV NSCLC Lung Cancer After Progression on First Line Therapy Containing Bevacizumab
This is an open label Phase II Trial that using the investigational anti-cancer agent, Pazopanib to see whether non-squamous non-small cell lung cancer will respond to its use by decreasing the size of the tumor or stopping its…
- Trial name
- LCCC0921 (NCT01262820)
- Testing
- Pazopanib
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Digital Breast Tomosynthesis Preference Study
Mammography remains the current standard in the detection of breast cancer. However, conventional two-view mammography will not detect all cancers.
- Trial name
- NRR (NCT00776126)
- Testing
- Digital Breast Tomosynthesis Exam
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lymphoma
Bortezomib, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory Low-Grade, Follicular, or Mantle Cell Non-Hodgkin's Lymphoma
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, and radiolabeled monoclonal antibodies, such as yttrium Y 90 ibritumomab…
- Trial name
- NCT00334438
- Testing
- rituximab, bortezomib, yttrium Y 90 ibritumomab tiuxetan
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Leukemia
Exercise and Quality of Life in Leukemia Patients
The purpose of this study is to evaluate the impact of an exercise intervention on patient-reported anxiety, depression, fatigue, and sleep disturbances among acute leukemia patients.
- Trial name
- EQUAL (NCT02246907)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Multiple Myeloma, Plasma Cell Neoplasm
Biomarkers Related to Thrombosis in Patients With Newly Diagnosed Multiple Myeloma Receiving Chemotherapy
RATIONALE: Studying samples of blood in the laboratory from patients receiving chemotherapy may help doctors learn more about the effects of chemotherapy on cells.
- Conditions
- Multiple Myeloma, Plasma Cell Neoplasm, Thromboembolism
- Trial name
- NCT01132833
- Testing
- enzyme-linked immunosorbent assay, laboratory biomarker analysis, medical chart review
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart
The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold (DIBH), the technique used at the University of North Carolina (UNC) for left-side breast cancer radiation therapy, can reduce side effects to…
- Trial name
- NCT01849614
- Testing
- Cardiac SPECT perfusion scan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Advanced Adult Hepatocellular Carcinoma
Everolimus and Pasireotide (SOM230) in Patients With Advanced or Metastatic Hepatocellular Carcinoma
The purpose of this study is to estimate the time to disease progression when everolimus and pasireotide are given together in patients with advanced or metastatic HCC who have not had any prior systemic therapy.
- Trial name
- NCT01488487
- Testing
- Everolimus, Pasireotide
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Mammography Reminders for Encouraging Women to Undergo Regular Mammography Screenings for Breast Cancer
RATIONALE: Mammography reminders may encourage women to undergo regular mammography screenings for breast cancer. PURPOSE: This randomized clinical trial is studying three different mammography reminder interventions to compare…
- Trial name
- NCT01148875
- Testing
- Mammography appointment reminders; telephone counseling
- Volunteers
- 3,547 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Body Weight Changes, Breast Neoplasms
The Use of Smart Scales for Weight Gain Prevention in African American Breast Cancer Survivors
The purpose of this study is to test the feasibility of two 6-month behavioral interventions for weight gain prevention (self-regulation plus activity monitoring or self-regulation) among African American breast cancer survivors…
- Trial name
- NCT02030353
- Testing
- Self-regulation plus activity monitoring, Self-regulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer
Improving Survivorship Care Through Enhanced Communication and Coordination: Pilot Study
Purpose: Cancer survivorship is a high clinical and research priority both nationally and at the University of North Carolina. The investigators propose a randomized pilot study testing the development, implementation and…
- Trial name
- NCT02111616
- Testing
- Survivorship Care Plan (SCP), Coordinated PCP visit
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Stem Cell Transplantation, Hematopoietic
Evaluation of Cardiorespiratory Performance After Interval Exercise Training Prior to Hematopoietic Cell Transplantation
The primary objective of this study is to demonstrate the efficacy of a pre-transplant, interval exercise training (IET) intervention, in increasing peak oxygen uptake (VO2peak) scores on cycle ergometry.
- Trial name
- NCT02577939
- Testing
- Interval Exercise Training (IET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer, Diarrhea
Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT01164215
- Testing
- fluorouracil, leucovorin, oxaliplatin
- Where
- 5 sites in United States
- Volunteers
- 76 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Biomarkers in Blood Samples From Older Breast Cancer Survivors
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01138345
- Testing
- gene expression analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Cancer
Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer
The overall goal of this proposal is to investigate the potential benefit of metformin as a novel therapy for the treatment of endometrial cancer.
- Trial name
- NCT01911247
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Endometrial Cancer
Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of genistein may be effective in preventing breast or endometrial cancer.
- Trial name
- NCT00099008
- Testing
- Genistein
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Non Small Cell Lung Cancer
Induction Chemotherapy Using Paclitaxel, Carboplatin, CPT-11 With Pegfilgrastim
Patients enrolled on this study will have been diagnosed with non-small cell lung cancer which cannot be removed by an operation.
- Trial name
- NCT00280787
- Testing
- Paclitaxel, Carboplatin, CPT-11
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Trastuzumab and External Beam Radiation Therapy in Treating Women With Stage III or Stage IV Breast Cancer
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00943410
- Testing
- external beam radiation therapy, Herceptin
- Volunteers
- 19 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center