Clinical trials: sponsored by UNC Lineberger Comprehensive Cancer Center
Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma
Administration of T Lymphocytes for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma (CART CD30)
The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells.
- Trial name
- NCT01316146
- Testing
- CAR.CD30 T cells
- Where
- 3 sites in United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CML, Chronic Phase, CML (Chronic Myelogenous Leukemia
Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients
The purpose of this prospective, single-institution observational study is to evaluate associations between the pharmacokinetic (PK) parameters for tyrosine kinase inhibitors (TKIs) used to treat chronic phase chronic myeloid…
- Conditions
- CML, Chronic Phase, CML (Chronic Myelogenous Leukemia, CML - Philadelphia Chromosome, Chronic Myeloid Leukemia
- Trial name
- NCT03885830
- Testing
- Bosutinib, Dasatinib, Imatinib
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Esophageal Squamous Cell Carcinoma
HIV and Other Risk Factors for Esophageal Squamous Cell Carcinoma in Malawi
The primary purpose of this single-center, case-control, non-interventional study is to determine risk factors which contribute to the development of esophageal squamous cell carcinoma (ESCC) at Kamuzu Central Hospital (KCH) and…
- Trial name
- NCT03160209
- Where
- 2 sites in Malawi
- Volunteers
- 600 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Selective Image Guided Resection of Pathologically Documented Axillary Lymph Node Metastases
The purpose of this research study is to determine how feasible and accurate identifying and removing specific lymph nodes in the axilla (armpit) after neoadjuvant systemic therapy is when patients present with breast cancer that…
- Trial name
- TAD (NCT03281720)
- Testing
- TAD
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Cancer, Uterine Cervical Neoplasms
Effect of Human Papillomavirus Self-Collection on Cervical Cancer Screening in High Risk Women: My Body, My Test 3
This study will investigate whether cervical cancer screening completion among under-screened women could be improved by offering HPV (human papillomavirus) testing by at-home self-collection followed by screening invitation…
- Conditions
- Cervical Cancer, Uterine Cervical Neoplasms, Human Papillomavirus
- Trial name
- MBMT-3 (NCT02651883)
- Testing
- Screening invitation (with education), Self-collection for HPV testing
- Where
- United States
- Volunteers
- 665 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Tobacco Use, Cigarette Use
Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes
Tobacco use is the leading preventable cause of cancer and cancer deaths in the US. While most (69%) smokers want to quit, only 6% succeed in doing so each year.
- Trial name
- NCT04974489
- Testing
- Emotion-based messages about the harm of VLNC, Continued-harm-framed messages about the harm of VLNC, Myth-refuting messages about the harm of VLNC
- Where
- United States
- Volunteers
- 1,153 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Diffuse Large B-cell Lymphoma, HIV
Rituximab Plus CHOP Chemotherapy for Diffuse Large B-cell Lymphoma
The purpose of this study is to establish the safety of rituximab plus cyclophosphamide, doxorubicin, vincristine,prednisone (R-CHOP) in HIV-infected and HIV-uninfected diffuse large B-cell lymphoma (DLBCL) patients in Malawi.
- Trial name
- NCT02660710
- Testing
- R-CHOP
- Where
- Malawi
- Volunteers
- 39 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
A Patient Portal Tool, E-assist, for Supporting CRC Screening
To compare patient perceptions, intent to screen, and screening use among those using a patient portal with and without a colorectal cancer (CRC) screening decision support tool, e-assist.
- Trial name
- NCT02798224
- Testing
- e-assist: Colon Health, Healthwise Educational Program
- Where
- United States
- Volunteers
- 1,826 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Oncology
The STEPP Study: Sensors To Evaluate Physical Performance
This study assesses the association between digital functional measures of physical and patient-reported standard onocological assessments, like Karnofsky Performance Score (KPS).
- Trial name
- STEPP (NCT03952767)
- Testing
- Digital Physical Measures and Survey Assessments
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Circulating Tumor Cells
Investigation of Circulating Tumor Cells From Cancer Patients Undergoing Radiation Therapy
The purpose of this study is to investigate the level of Circulating Tumor Cells (CTCs) in cancer patients before and after undergoing treatment regimens where the primary treatment modality is radiation therapy (XRT).
- Trial name
- NCT02449837
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Solid Tumor, Adult
Circulating Tumor Cells in Solid Tumors
The purpose of this study is to identify circulating tumor cells in patients with solid tumors. Quantify and characterize these cells, collect patient information in regards to the patient's cancer.
- Trial name
- NCT03161821
- Testing
- Observational
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
Biomarkers in Patients With Rectal Cancer Undergoing Chemotherapy and Radiation Therapy
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00280761
- Testing
- capecitabine, 5-fluorouracil, Surgical Resection
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Clinical Evaluation of Primary Sampling Scatter Correction for Chest Tomosynthesis
This is a study that will evaluate the utility of a scatter reduction technique in reducing dose and increasing the sensitivity of stationary digital chest tomosynthesis (s-DCT) in the detection of lung lesions.
- Trial name
- NCT04076696
- Testing
- Scatter corrected s-DCT
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Patient-centered Communication About Healthy Weight in Early Breast Cancer
Comorbidities in breast cancer survival account for 49% of overall survival difference between black and white women. Many obesity-related comorbidities disproportionately affect black women, therefore pointing to a need to…
- Trial name
- NCT04504201
- Testing
- Focus Group
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HPV Vaccine, Provider Communication Practices
Mobile Coaching to Improve HPV Vaccine Delivery
The purpose of this study is to examine the feasibility of using Checkup Coach, a mobile coaching intervention, to improve the way that primary care providers recommend HPV vaccination to adolescent patients and their parents.
- Conditions
- HPV Vaccine, Provider Communication Practices, Vaccine Recommendation Practices
- Trial name
- NCT05105711
- Testing
- QI coaching intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Non Small Cell Lung Cancer
Phase II Trial of Sequential Consolidation With Pembrolizumab Followed by Nab-paclitaxel
The purpose of this research study is to test the effectiveness of three treatment arms that are designed to improve survival in patients with non-small cell lung cancer.
- Trial name
- NCT02684461
- Testing
- Pembrolizumab
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Signs and Symptoms
Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules
Purpose: The proposed research, if successfully implemented, will result in a low-dose, low-cost, and highly effective method for screening of lung cancer, leading to reduction of the lung cancer mortality rate.
- Trial name
- NCT02075320
- Testing
- Stationary Digital Chest Tomosynthesis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Signs and Symptoms
Academic-Industrial Partnership for Translation of Acoustic Angiography
Purpose: The primary objective of this single arm study is to compare the sensitivity and specificity of acoustic angiography with traditional b-mode ultrasound in the distinction of malignant versus benign breast lesions.
- Trial name
- NCT03544268
- Testing
- Acoustic Angiography, Definity
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Myeloid Leukemia
Lenalidomide as Consolidation and Maintenance in Adults >/= 60 Years of Age With AML Following Standard Induction
The purpose of this research study is to test the safety of the study drug, lenalidomide, at different dose levels in people diagnosed with acute myeloid leukemia (AML) who have finished standard induction therapy and have had a…
- Trial name
- NCT01578954
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Breast Cancer
Physical Activity to Maintain Quality of Life and Physical Function in Women With Metastatic Breast Cancer: a Pilot Study
Metastatic breast cancer (MBC) is an incurable disease. Maintaining optimum quality of life is a major goal of care. There is a strong body of evidence that exercise can reduce or manage fatigue, depression and insomnia in breast…
- Trial name
- NCT02682836
- Testing
- Walk with Ease
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center